Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: Compositions comprising crosslinked polysaccharides, particularly levan and/or dextran, may provide advantageous benefits when admixed with concrete blends. Suitable compositions may comprise a biologically sourced surfactant, and a crosslinked polysaccharide, in which the crosslinked polysaccharide comprises at least one crosslinking group bonded via ether linkages to a first polysaccharide chain and a second polysaccharide chain. Concrete blends may comprise such compositions, a cement and water. Methods for forming and/or using the concrete blends may comprise allowing the concrete blends to form a hardened mass.

Abstract: Wine and liquor bottles have a shrink-wrap seal, or other type, that is applied to the cap/cork end of the bottle. This seal material can be loaded with randomly magnetized particles, such as flakes of an alloy of neodymium, iron, and boron (“NdFeB”). The randomly magnetized particles provide a unique unclonable magnetic fingerprint to the bottle. The magnetic field may be recorded for one or more circumferential bands around the surface of the bottle's neck and used as a magnetic fingerprint to authenticate the bottle. Authentication can be performed by inserting the bottle in an appropriate fixture, which measures the magnetic fingerprint.

Abstract: Compositions comprising crosslinked polysaccharides, particularly levan and/or dextran, may provide advantageous benefits when admixed with concrete blends. Suitable compositions may comprise a biologically sourced surfactant, and a crosslinked polysaccharide, in which the crosslinked polysaccharide comprises at least one crosslinking group bonded via ether linkages to a first polysaccharide chain and a second polysaccharide chain. Concrete blends may comprise such compositions, a cement and water. Methods for forming and/or using the concrete blends may comprise allowing the concrete blends to form a hardened mass.

Abstract: A rail pad can have a major face forming a railseat portion on which a foot of a railway rail sits when the pad is in use, the railseat portion having opposite side edges to at least part of each of which a respective upstanding portion of the pad can be connected, wherein the pad does not have any part which extends laterally from the railseat portion in a same plane as the railseat portion. The respective upstanding portion can be connected to a projection of the rail pad which extends laterally from the respective upstanding portion such that the projection can be vertically spaced from, and does not overhang, the railseat portion, the projection spaced from ends of the respective upstanding portion such that the projection can be configured to interlock with a corresponding opening in a front part of one of the railway rail clip anchoring devices.

Abstract: A rail pad can have a major face forming a railseat portion on which a foot of a railway rail sits when the pad is in use, the railseat portion having opposite side edges to at least part of each of which a respective upstanding portion of the pad can be connected, wherein the pad does not have any part which extends laterally from the railseat portion in a same plane as the railseat portion. The respective upstanding portion can be connected to a projection of the rail pad which extends laterally from the respective upstanding portion such that the projection can be vertically spaced from, and does not overhang, the railseat portion, the projection spaced from ends of the respective upstanding portion such that the projection can be configured to interlock with a corresponding opening in a front part of one of the railway rail clip anchoring devices.

Abstract: A resilient railway rail fastening clip (3) has successive first to seventh portions (31 to 37), where in a non-operative configuration, the first and seventh portions (31, 37) form leg portions lying in a first plane (P), the second and sixth portions extend substantially away from and above the first plane (P), at least parts of the third and fifth portions (33, 35) extend towards and above the first plane (P) with their longitudinal axes lying substantially in a second plane (R) that intersects the first plane (P) at a first acute angle ?, and the fourth portion (34) extends substantially in or below the first plane (P) with its longitudinal axis lying substantially in a third plane (Q) that intersects the first plane (P) at a second acute angle ?, where 0°<?<?.

Abstract: In a railway rail fastening clip 1 for fastening a railway rail to an underlying rail foundation, which clip 1 is formed of an elongate plate shaped such that a central region 11 of the plate has in profile the form of a letter C, a first end region of the plate extending from one side of the central region 11 of the plate to form a substantially planar base portion 12 of the clip for engaging a rail fastening anchoring device secured to the rail foundation and a second end region of the plate extending from the opposite side of the central region 11 of the plate to form a toe portion 13 of the clip for bearing on a foot of the railway rail, such that in profile the second end region extends further than the first end region, the toe portion of the clip is provided with a throughhole 14 which is arranged such that, when the clip is in its operative configuration, part or all of the throughhole 14 lies above the foot of the rail, the throughhole being configured to receive a corresponding spigot 25 of a toe in

Abstract: A resilient railway rail fastening clip (3) has successive first to seventh portions (31 to 37) where, when the clip (3) is in a non-operative configuration, the first and seventh portions (31, 37) of the clip (3) form leg portions which lie in a first plane (P), the second and sixth portions extend substantially away from and above the first plane (P), at least parts of the third and fifth portions (33, 35) extend towards and above the first plane (P) such that the longitudinal axes of the third and fifth portions (33, 35) lie substantially in a second plane (R), different from the said first plane (P), which second plane (R) intersects the first plane (P) at a first acute angle ?, and the fourth portion (34) extends substantially in or below the said first plane (P) such that the longitudinal axis of the fourth portion (34) lies substantially in a third plane (Q) which is different to the said second plane (R) and intersects the said first plane (P) at a second acute angle ?, where 0°??<?.

Abstract: A railway rail pad (1), for use beneath a railway rail in a rail fastening assembly as cushioning and/or electrical insulation, has first and second major faces (2, 3), the first face (2) having a rail seat portion (20) on which a foot of a railway rail sits when the pad (1) is in use, and side members (4A, 4B) attached to and extending from two opposite edges of the first face (2) of the pad (1). The side members (4A, 4B) are arranged so as to be located on respective opposite sides of the railway rail when the pad (1) is in use such that the rail seat portion (20) of the pad (1) lies between respective inwardly-facing wall faces (41A, 41B) of the said side members (4A, 4B).

Abstract: An electrical insulator for use with a rail fastening clip comprises a contact member providing on one side a substantially flat rail contact surface for contacting a foot of a rail and on the opposing side a clip contact surface for contacting a rail bearing surface of a bearing portion of the clip, the insulator also having retaining means for retaining the insulator on the clip in such a way as to allow rotation of the insulator about a longitudinal axis of the bearing portion of the clip. The insulator has stop portions for limiting such rotation about the longitudinal axis of the bearing portion of the clip to a desired extent. The clip contact surface of the insulator is convex, in a vertical plane which is perpendicular to the longitudinal axis of the bearing portion of the clip, such that, when the insulator is attached to a clip having a flat rail bearing surface, a contact region between the flat rail bearing surface of the clip and the clip contact surface of the insulator is linear.

Abstract: The present disclosure generally pertains to systems and methods for tracking vehicle riders, such as students riding in a school bus, for example. In one embodiment, the disclosed system has a biometric device, such as a palm vein reader, configured to identify users who are expected to ride a school bus. When a student rider either gets on or off the bus, the biometric device is used to identify the rider. An automated controller on the bus maintains a list of expected passengers on the bus, and based on the biometric device, the controller maintains data, referred to hereafter as “rider data,” indicating whether each expected passenger is currently on the bus. The rider data is updated, in real time, as riders get on and off the bus at various stops.

Abstract: In a railway rail fastening clip 1 for fastening a railway rail to an underlying rail foundation, which clip 1 is formed of an elongate plate shaped such that a central region 11 of the plate has in profile the form of a letter C, a first end region of the plate extending from one side of the central region 11 of the plate to form a substantially planar base portion 12 of the clip for engaging a rail fastening anchoring device secured to the rail foundation and a second end region of the plate extending from the opposite side of the central region 11 of the plate to form a toe portion 13 of the clip for bearing on a foot of the railway rail, such that in profile the second end region extends further than the first end region, the toe portion of the clip is provided with a throughhole 14 which is arranged such that, when the clip is in its operative configuration, part or all of the throughhole 14 lies above the foot of the rail, the throughhole being configured to receive a corresponding spigot 25 of a toe in

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger.

Abstract: A railway rail pad (1), for use beneath a railway rail in a rail fastening assembly as cushioning and/or electrical insulation, has first and second major faces (2, 3), the first face (2) having a rail seat portion (20) on which a foot of a railway rail sits when the pad (1) is in use, and side members (4A, 4B) attached to and extending from two opposite edges of the first face (2) of the pad (1). The side members (4A, 4B) are arranged so as to be located on respective opposite sides of the railway rail when the pad (1) is in use such that the rail seat portion (20) of the pad (1) lies between respective inwardly-facing wall faces (41A, 41B) of the said side members (4A, 4B).

Abstract: An electrical insulator for use with a rail fastening clip comprises a contact member providing on one side a substantially flat rail contact surface for contacting a foot of a rail and on the opposing side a clip contact surface for contacting a rail bearing surface of a bearing portion of the clip, the insulator also having retaining means for retaining the insulator on the clip in such a way as to allow rotation of the insulator about a longitudinal axis of the bearing portion of the clip. The insulator has stop portions for limiting such rotation about the longitudinal axis of the bearing portion of the clip to a desired extent. The clip contact surface of the insulator is convex, in a vertical plane which is perpendicular to the longitudinal axis of the bearing portion of the clip, such that, when the insulator is attached to a clip having a flat rail bearing surface, a contact region between the flat rail bearing surface of the clip and the clip contact surface of the insulator is linear.

Abstract: A system enables clinicians to use naturally spoken voice commands from a small, wearable, wireless badge (or other portable device) to trigger events including, application session transfer, wireless communications (such as voice calls) and control of electronic devices. A system for managing user operation sessions on multiple servers includes an interface for receiving, from a first workstation, a request to initiate a current session of operation of a particular executable application on a first server and user identification information from a particular user. A session processor, in response to the received particular user identification information, identifies an active session of operation of the particular user on a second server previously initiated via a second workstation and re-attaches connection of the previously initiated active session of operation to the first workstation as the current session in response to a user voice command.

Abstract: A system automatically establishes context information (e.g., determining changes to user interface workflows, screens, menus, and access requirements for devices such as monitors, ventilators, and diagnostic equipment) used by a worker in using healthcare information applications based on patient geographic location (e.g., a room or bed or department). The system addresses the need for a user to sign onto a system with each location change and manually change context information which consumes computer, server and network resources and represent a potential security problem. A healthcare system selects information to be provided to a user in response to received location dependent context data. The system includes a proximity detector for wirelessly detecting presence of an identification tag substantially within a predetermined vicinity of the detector. The identification tag is associated with at least one of, (a) a particular processing device and (b) a particular person.