Patents by Inventor Christopher H. Hill

Christopher H. Hill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxamide IMPDH inhibitors
    Publication number: 20020052513
    Abstract: Disclosed are compounds of the general formula 1
    Type: Application
    Filed: February 8, 2001
    Publication date: May 2, 2002
    Inventors: Michael J. Broadhurst, Christopher H. Hill, David N. Hurst, Philip S. Jones, Paul B. Kay, Ian R. Kilford, Robert M. McKinnell
  • Process for the preparation of 2-substituted and 2,3-disubstituted maleimides
    Patent number: 5399712
    Abstract: The invention relates to a process for the manufacture of substituted maleimides of the formula ##STR1## wherein R.sup.1 is alkyl, aryl or heteroaryl and R.sup.2 is hydrogen, alkyl, alkoxycarbonyl, aryl or heteroaryl, by reacting an activated glyoxylate of the formula ##STR2## wherein R.sup.1 has the above significance and X is a leaving atom or group,with an imidate of the formula ##STR3## wherein R.sup.2 has the above significance, R.sup.3 is alkyl, aryl or trialkylsilyl and Y is oxygen or sulfur, in the presence of a base and, after treating the resulting reaction product obtained in which R.sup.2 is hydrogen or alkyl with a strong base, hydrolyzing and dehydrating the resulting hydroxy-pyrrolinone of the formula ##STR4## wherein R.sup.1, R.sup.2, R.sup.3 and Y have the above significance.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: March 21, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Christopher H. Hill
  • Substituted pyrroles
    Patent number: 5292747
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X, m, n, p, and q are as set forth in the specification, as well as pharmaceutically acceptable salts of acidic compounds of formula I with bases and of basic compounds of formula I with acids, which are useful in the control or prevention of inflammatory, immunological, oncological, bronchopulmonary, dermatological or cardiovascular disorders or for the treatment of asthma, AIDS or diabetic complications or for the stimulation of hair growth are described.
    Type: Grant
    Filed: September 21, 1992
    Date of Patent: March 8, 1994
    Assignee: Hoffman-La Roche Inc.
    Inventors: Peter D. Davis, Christopher H. Hill, Goeffrey Lawton
  • Substituted pyrroles
    Patent number: 5057614
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Y have the signficance given in the description, are useful in the control or prevention of inflammatory, immunological, bronchopulmonary or cardiovascular disorders.
    Type: Grant
    Filed: February 6, 1989
    Date of Patent: October 15, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Peter D. Davis, Christopher H. Hill, Geoffrey Lawton
  • Substituted pyrroles
    Patent number: RE36736
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Y have the signficance given in the description, are useful in the control or prevention of inflammatory, immunological, bronchopulmonary or cardiovascular disorders.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: June 13, 2000
    Assignee: Hoffman-La Roche Inc.
    Inventors: Peter D. Davis, Christopher H. Hill, Geoffrey Lawton