Abstract: Provided herein are certain compounds and imaging agents useful for detecting a condition or disorder associated with protein aggregation, compositions thereof, and methods of their use.

Abstract: Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.

Abstract: Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.

Abstract: Selective training of neural networks using motion estimation, including: selecting, from a plurality of pixels in video data from a vehicle, based on motion relative to the vehicle, one or more pixels; and training a neural network based on the video data by zeroing out an error function applied to the selected one or more pixels.

Abstract: Devices and methods of rocket propulsion are disclosed. In one aspect, a staged combustion liquid rocket engine with preburner and turbopump unit (TPU) integrated into the structure of the combustion chamber is described. An initial propellant mixture is combusted in a preburner combustion chamber formed as an annulus around a main combustion chamber, the combustion products from the preburner driving the turbine of the TPU and subsequently injected into the main combustion chamber for secondary combustion along with additional propellants, generating thrust through a supersonic nozzle. The preburner inner cylindrical wall is shared with the outer cylindrical wall of the engine's main combustion chamber and the turbine is axially aligned with the main combustion chamber.

Abstract: A unified platform obtains, stores, and shares search results based on user profiles or groups with a common interest. User profiles or group profiles may be used to identify categories containing objects related to a common interest, and the objects may be selected for placement in a graphical user interface from which they may be purchased by or for the user. The objects may preferably be virtual objects stored in a virtual locker or other virtual display unit. Users are able to conduct web-based searches for products or services from different websites and store dimensional representations of virtual products or services in a unified platform.

Abstract: Methods and systems for manipulating surface topology of additively manufactured fluid interacting structures, such as additively manufactured heat exchangers or airfoils, and associated additively manufactured articles, are disclosed. In one aspect, an article which interacts with a fluid is imparted with surface topology features which affect performance parameters related to the fluid flow. The topological features may be sequenced, combined, intermixed, and functionally varied in size and form to locally manipulate and co-optimize multiple performance parameters at each or selectable differential lengths along a flow path. The co-optimization method may uniquely prioritize selectable performance parameters at different points along the flow path to improve or enhance overall system performance.

Abstract: Devices and methods of rocket propulsion are disclosed. In one aspect, a staged combustion liquid rocket engine with preburner and turbopump unit (TPU) integrated into the structure of the combustion chamber is described. An initial propellant mixture is combusted in a preburner combustion chamber formed as an annulus around a main combustion chamber, the combustion products from the preburner driving the turbine of the TPU and subsequently injected into the main combustion chamber for secondary combustion along with additional propellants, generating thrust through a supersonic nozzle. The preburner inner cylindrical wall is shared with the outer cylindrical wall of the engine's main combustion chamber and the turbine is axially aligned with the main combustion chamber.

Abstract: Methods and systems for manipulating surface topology of additively manufactured fluid interacting structures, such as additively manufactured heat exchangers or airfoils, and associated additively manufactured articles, are disclosed. In one aspect, an article which interacts with a fluid is imparted with surface topology features which affect performance parameters related to the fluid flow. The topological features may be sequenced, combined, intermixed, and functionally varied in size and form to locally manipulate and co-optimize multiple performance parameters at each or selectable differential lengths along a flow path. The co-optimization method may uniquely prioritize selectable performance parameters at different points along the flow path to improve or enhance overall system performance.

Abstract: Depth camera settings are adjusted based on characteristics of items presented in a scan zone and based on depth values returned for the items in depth images. Red-Green-Blue (RGB) images and depth images are captured of items within the scan zone. Quality of the depth values are accessed. Bad depth values are replaced with good known depth values. When the depth values are not replaced, one or more depth value interpolation algorithms are selectively processed to enhance the depth values. The depth values are processed to place each item within a specific location of the scan zone and map that location to pixel values in the corresponding RGB images. The pixel values from the RGB images are passed to a classification model and an item code is returned. The item codes are provided to checkout a customer without any scanning of item barcodes of the items.

Abstract: Devices and methods of rocket propulsion are disclosed. In one aspect, a staged combustion liquid rocket engine with preburner and turbopump unit (TPU) integrated into the structure of the combustion chamber is described. An initial propellant mixture is combusted in a preburner combustion chamber formed as an annulus around a main combustion chamber, the combustion products from the preburner driving the turbine of the TPU and subsequently injected into the main combustion chamber for secondary combustion along with additional propellants, generating thrust through a supersonic nozzle. The preburner inner cylindrical wall is shared with the outer cylindrical wall of the engine's main combustion chamber and the turbine is axially aligned with the main combustion chamber.

Abstract: Methods and systems for manipulating surface topology of additively manufactured fluid interacting structures, such as additively manufactured heat exchangers or airfoils, and associated additively manufactured articles, are disclosed. In one aspect, an article which interacts with a fluid is imparted with surface topology features which affect performance parameters related to the fluid flow. The topological features may be sequenced, combined, intermixed, and functionally varied in size and form to locally manipulate and co-optimize multiple performance parameters at each or selectable differential lengths along a flow path. The co-optimization method may uniquely prioritize selectable performance parameters at different points along the flow path to improve or enhance overall system performance.

Abstract: A unified platform obtains, stores, and shares search results based on user profiles or groups with a common interest. User profiles or group profiles may be used to identify categories containing objects related to a common interest, and the objects may be selected for placement in a graphical user interface from which they may be purchased by or for the user. The objects may preferably be virtual objects stored in a virtual locker or other virtual display unit. Users are able to conduct web-based searches for products or services from different websites and store dimensional representations of virtual products or services in a unified platform.

Abstract: A unified platform obtains, stores, and shares search results based on user profiles or groups with a common interest. User profiles or group profiles may be used to identify categories containing objects related to a common interest, and the objects may be selected for placement in a graphical user interface from which they may be purchased by or for the user. The objects may preferably be virtual objects stored in a virtual locker or other virtual display unit. Users are able to conduct web-based searches for products or services from different websites and store dimensional representations of virtual products or services in a unified platform.

Abstract: Provided are systems, methods, and machine-readable storage media for presenting animations overlying multimedia files in accordance with the present disclosure. Embodiments are described for linking an animation to a multimedia file and presenting the animation overlying a concurrent playback of the multimedia file (e.g., its content). Embodiments are described for including additional elements to the presentation of the animation outside of the playback of the animation, including residual elements that relate to the content of the animation and/or allow a user to receive further information about the content of the animation. Embodiments are described for linking an animation to more than one multimedia file.

Abstract: A method for repairing a discharge ring of a hydraulic turbine with a turbine runner in place includes: mounting adjustable fixtures to runner blades that are approximately evenly spaced around the turbine runner, where each adjustable fixture is mounted to a different runner blade at a different predetermined vertical position with respect to a surface of the discharge ring; attaching cutting equipment configured to remove material from the discharge ring to each adjustable fixture installed on the runner blades; installing a drive unit configured to rotate the turbine runner; controlling the drive unit to rotate the runner at a specified speed; and controlling the cutting equipment attached to each adjustable fixture to concurrently remove material from the discharge ring as the turbine runner rotates.

Abstract: Devices and methods of rocket propulsion are disclosed. In one aspect, a staged combustion liquid rocket engine with preburner and turbopump unit (TPU) integrated into the structure of the combustion chamber is described. An initial propellant mixture is combusted in a preburner combustion chamber formed as an annulus around a main combustion chamber, the combustion products from the preburner driving the turbine of the TPU and subsequently injected into the main combustion chamber for secondary combustion along with additional propellants, generating thrust through a supersonic nozzle. The preburner inner cylindrical wall is shared with the outer cylindrical wall of the engine's main combustion chamber and the turbine is axially aligned with the main combustion chamber.

Abstract: The invention may provide, in part, compounds for use as antiproliferative, chemotherapeutic, antiviral, cell sensitising or adjuvant agents, and pharmaceutical compositions including the compounds. The compounds may be for use in treating diseases and disorders related to cell proliferation such as cancer, or in treating diseases and disorder which are linked to aberrant control of protein synthesis, such as cancer, viral infection, muscle wasting, autistic spectrum disorders, Alzheimer's disease, Huntingdon's disease and Parkinson's disease.

Abstract: Devices and methods of rocket propulsion are disclosed. In one aspect, a staged combustion liquid rocket engine with preburner and turbopump unit (TPU) integrated into the structure of the combustion chamber is described. An initial propellant mixture is combusted in a preburner combustion chamber formed as an annulus around a main combustion chamber, the combustion products from the preburner driving the turbine of the TPU and subsequently injected into the main combustion chamber for secondary combustion along with additional propellants, generating thrust through a supersonic nozzle. The preburner inner cylindrical wall is shared with the outer cylindrical wall of the engine's main combustion chamber and the turbine is axially aligned with the main combustion chamber.

Abstract: The present disclosure pertains to a light system for mounting to an automobile that alerts surrounding vehicles to emergency conditions on the automobile without the necessity of establishing electrical communication with the control system of the automobile. The light system utilizes a movable contactor that serves to activate and deactivate the light when the light system is tilted.