Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: A microfluidic lab-on-a-chip (LOC) device, microfluidic systems, and associated methodology are described that allow for intelligently collecting environmental DNA (eDNA) and their associated metadata. Optical spectroscopy is integrated with filtration membranes on the microfluidic device. The microfluidic LOC device and systems can be used for selectively capturing targeted species based on optical characteristics and for recording relevant metadata on eDNA acquired by the filtration membranes.

Abstract: A display system comprising a steerable display having a monocular field of view of at least 1 degree, positioned within a scannable field of view of at least 20 degrees, the steerable display positioned for a user. In one embodiment, the steerable display is positioned for the user's fovea.

Abstract: Method and apparatus are disclosed for GNSS statistical speed calibration An example vehicle includes a wheel, a speed sensor for determining a first vehicle speed, an inertial sensor, and a processor. The processor may be configured for determining a second vehicle speed based on information from the inertial sensor and information from a satellite based system, determining that a difference between the first and second vehicle speeds is statistically significant, and responsively adjusting a value of the radius of the wheel.

Abstract: Method and apparatus are disclosed for GNSS statistical speed calibration An example vehicle includes a wheel, a speed sensor for determining a first vehicle speed, an inertial sensor, and a processor. The processor may be configured for determining a second vehicle speed based on information from the inertial sensor and information from a satellite based system, determining that a difference between the first and second vehicle speeds is statistically significant, and responsively adjusting a value of the radius of the wheel.

Abstract: The present disclosure provides a system and method for managing tire pressure for a trailer. A controller may be configured to manage communications between a vehicle and a trailer. A tire pressure management system module to be mounted on the trailer may be operatively connected to the controller by a tow connector. The tire pressure management system module may be configured to receive tire pressure information from at least one sensor operatively associated with at least one tire of the trailer, and transmit messages to the controller based on the tire pressure information, wherein the controller triggers a notification when at least one of the messages indicates a tire pressure that fails to meet a criteria.

Abstract: A food preparation table includes a food item catchment system including a modular grate and catch pan arrangement positioned atop an upwardly facing surface of the table and including multiple catch pans, multiple frames and multiple grates, each of which is removable for cleaning of the upwardly facing surface and for cleaning of the catch pans, frames and grates.

Abstract: A transition adapter component of a ventilator aerosol delivery system for delivering an aerosol to a patient, includes a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a heated capillary and a gas connection port for receiving carrier gas from a ventilator, which is in communication with a plurality of gas entry ports within the transition adapter. An inner cavity of the transition adapter receives the aerosol from the heated capillary and the streams of carrier gas from the plurality of gas exit ports within the transition adapter and directs the streams of carrier gas at least partially encircling and in parallel with the aerosol. An exit port on the distal end of the transition adapter housing delivers an entrained aerosol to an aerosol delivery connector.

Abstract: The present disclosure provides a system and method for managing tire pressure for a trailer. A controller may be configured to manage communications between a vehicle and a trailer. A tire pressure management system module to be mounted on the trailer may be operatively connected to the controller by a tow connector. The tire pressure management system module may be configured to receive tire pressure information from at least one sensor operatively associated with at least one tire of the trailer, and transmit messages to the controller based on the tire pressure information, wherein the controller triggers a notification when at least one of the messages indicates a tire pressure that fails to meet a criteria.

Abstract: The present disclosure provides, inter alia, methods and pharmaceutical compositions for treating or ameliorating amyotrophic lateral sclerosis (ALS). Among the various aspects of the present disclosure is the provision of methods and pharmaceutical compositions for treating or ameliorating ALS. Briefly, therefore, the present disclosure is directed to a method for treating or ameliorating an effect of amyotrophic lateral sclerosis (ALS) comprising administering to a subject in need thereof a modulator of a gene selected from the group consisting of Phospholipase D1 (PLD1).

Abstract: Systems and methods are described for monitoring a communicative connection with a trailer. Messages transmitted between a tire pressure management module of a trailer and a controller of a vehicle may be monitored. A notification may be triggered when the controller has not received a message from the tire pressure management module during at least a predetermined period of time.

Abstract: A transition adapter component of a ventilator aerosol delivery system for delivering an aerosol to a patient, includes a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a heated capillary and a gas connection port for receiving carrier gas from a ventilator, which is in communication with a plurality of gas entry ports within the transition adapter. An inner cavity of the transition adapter receives the aerosol from the heated capillary and the streams of carrier gas from the plurality of gas exit ports within the transition adapter and directs the streams of carrier gas at least partially encircling and in parallel with the aerosol. An exit port on the distal end of the transition adapter housing delivers an entrained aerosol to an aerosol delivery connector.

Abstract: An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.

Abstract: The present disclosure provides a system and method for managing tire pressure for a trailer. A controller may be configured to manage communications between a vehicle and a trailer. A tire pressure management system module to be mounted on the trailer may be operatively connected to the controller by a tow connector. The tire pressure management system module may be configured to receive tire pressure information from at least one sensor operatively associated with at least one tire of the trailer, and transmit messages to the controller based on the tire pressure information, wherein the controller triggers a notification when at least one of the messages indicates a tire pressure that fails to meet a criteria.

Abstract: Systems and methods are described for monitoring a communicative connection with a trailer. Messages transmitted between a tire pressure management module of a trailer and a controller of a vehicle may be monitored. A notification may be triggered when the controller has not received a message from the tire pressure management module during at least a predetermined period of time.

Abstract: A food preparation table includes a food item catchment system comprising a modular grate and catch pan arrangement positioned atop an upwardly facing surface of the table and including multiple catch pans, multiple frames and multiple grates, each of which is removable for cleaning of the upwardly facing surface and for cleaning of the catch pans, frames and grates.

Abstract: Methods and tools for evaluating fit of eyewear are provided. In an exemplary embodiment, the method includes steps of evaluating coverage provided by an eyewear article on the face of the wearer and evaluating a gap formed between a peripheral edge of the eyewear article and the face of the wearer.

Abstract: An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.

Abstract: The present invention provides, inter alia, methods and pharmaceutical compositions for treating or ameliorating an effect of proximal spinal muscular atrophy (SMA) and methods for preventing or slowing motor neuron death in a subject having SMA. The methods include administering to a subject in need thereof a modulator of a gene selected from the group consisting of phosphodiesterase 1c (Pde1c), Calbindin 2 (Calb2), Egl nine homolog 3 (Eg13), Metabotropic glutamate receptor 8 (mGluR8), Syn aptotagmin 1 (Syt1), CUGBP, Elav-like family member 4 (Celf4), and combinations thereof in an amount effective to treat or ameliorate an effect of SMA. Also provided are methods for preventing or slowing motor neuron death.

Abstract: A vehicle orientation indicator comprises a sensor and a controller. The sensor is configured to sense a gravitational force component imposed on a vehicle. The controller is configured to determine an orientation of the vehicle with respect to a fixed plane based on the sensed gravitational force component and control an indicator device to provide a representation of the orientation of the vehicle. The controller is further configured to control the indicator device to update the representation of the orientation of the vehicle based on a change in the sensed gravitational force component as sensed by the sensor while a movement condition of the vehicle meets a prescribed condition, and to control the indicator device to refrain from updating the representation of the orientation of the vehicle while the movement condition fails to meet the prescribed condition.