Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12D, In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Compounds that inhibit KRas G12D; in particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A control device for an electric motor having a first set of coil windings arranged to form a first sub motor and a second set of coil windings arranged to form a second sub motor, wherein current flow in the first set of coil windings is controlled using a first pulse width modulation, PWM, having a first switching sequence and current flow in the second set of coil windings is controlled using a second PWM having a second switching sequence, the control device comprising means arranged to measure the current flow in each of the first set of coil windings, wherein upon determining that the sum of the current flow in the first set of coil windings is substantially non zero, deriving the first PWM values from voltage values used to generate the second PWM.

Abstract: A control device for an electric motor having a first set of coil windings arranged to form a first sub motor and a second set of coil windings arranged to form a second sub motor, wherein current flow in the first set of coil windings is controlled using a first pulse width modulation, PWM, having a first switching sequence and current flow in the second set of coil windings is controlled using a second PWM having a second switching sequence, the control device comprising means arranged to measure the current flow in each of the first set of coil windings, wherein upon determining that the sum of the current flow in the first set of coil windings is substantially non zero, deriving the first PWM values from voltage values used to generate the second PWM.

Abstract: One aspect of the present invention is to extract multiple ionic species in a FAIMS into one or more IMS drift tubes simultaneously. By adjusting FAIMS operational parameters, ions in FAIMS are detected on IMS detectors through separation in FAIMS and/or separation and collection in the IMS. This method provides a continuous separation of specific ions from an ion swarm by employing a high-field differential mobility analyzer (FAIMS) with a plurality of orthogonal transitions paths spaced incrementally along the electrodes which allow additional separation by a conventional IMS drift tube. The components of the sample can be collected or detected.

Abstract: One aspect of the present invention is to extract multiple ionic species in a FAIMS into one or more IMS drift tubes simultaneously. By adjusting FAIMS operational parameters, ions in FAIMS are detected on IMS detectors through separation in FAIMS and/or separation and collection in the IMS. This method provides a continuous separation of specific ions from an ion swarm by employing a high-field differential mobility analyzer (FAIMS) with a plurality of orthogonal transitions paths spaced incrementally along the electrodes which allow additional separation by a conventional IMS drift tube. The components of the sample can be collected or detected.

Abstract: The present invention is a method and apparatus to keep the electrospray ionization at a lower temperature than the heated chamber where the desolvation process occurs. The means to cool the electrosprayer is by actively removing heat from the apparatus through heat transfer methods. This apparatus and method can be used with any ionization apparatus at high temperatures preventing the ionization source from reaching a high temperature that may hinter the normal operation.

Abstract: A method of separating ions comprises applying a spot of a sample material to a target plate. The target plate is mounted in fluid communication with an ion inlet orifice of a FAIMS analyzer region and externally to the FAIMS analyzer region. Using a laser light source that is disposed external to the FAIMS analyzer region, the target plate is irradiated with light of a predetermined wavelength, the light of a predetermined wavelength being selected to affect the sample material applied to the target plate so as to produce ions of the sample material. The ions of the sample material are directed along an ion flow path between the target plate and FAIMS analyzer region, via the ion inlet orifice. A flow of a gas is directed counter-current to the ion flow path and passing through the target plate. The flow of gas through the target plate assists in desolvation of ions and directs neutral molecules away from the FAIMS analyzer region.