Abstract: The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Abstract: The present invention relates to methods for identifying one or more reporter genes for a particular biological pathway of interest. The reporter genes of this invention are particularly useful for analyzing the activity of particular biological pathways of interest, and may be further used in the design of drugs, drug therapies or other biological agents (e.g., insecticides, herbicides, fungicides, antibiotics, or antivirals) to target a particular biological pathway. The present invention also relates to methods for identifying one or more target genes for a particular biological pathway of interest. Target genes of the invention are useful as specific targets for drugs which may be designed to enhance, inhibit, or modulate a particular biological pathway. Methods to identify genes which modify the function or structure of a member (e.g., compound or gene product) of a particular biological pathway are provided.

Abstract: A piston for a low pressure fluid accumulator of a hydraulic control unit of a vehicle brake system includes a cylindrical body having an outer surface defining a first end surface of the piston. The first end surface includes a plurality of interconnected ridges. The ridges have outer surfaces and form cavities therebetween. Each ridge is adapted to provide a sealing surface between the first end surface of the piston and an inner surface of a fluid accumulator in which the piston may be inserted. In one embodiment of the invention, the closed end of the piston includes a thick self-supporting wall. A thin skirt extends from the thick self-supporting wall toward the open end of the piston. A plurality of axially extending skirt support ribs is formed on the inner surface of the piston skirt.

Abstract: The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticides, herbicides and anti-proliferation drugs. The present invention provides antisense molecules and ribozymes comprising sequences complementary to the sequences of mRNAs of essential genes that function to inhibit the essential genes. The present invention also provides neutralizing antibodies to proteins encoded by essential genes that bind to and inactivate the essential gene products. The present invention further provides pharmaceutical compositions for treating fungal and proliferative diseases, as well as methods of treatment of fungal and proliferative diseases.

Abstract: The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticides, herbicides and anti-proliferation drugs. The present invention provides antisense molecules and ribozymes comprising sequences complementary to the sequences of mRNAs of essential genes that function to inhibit the essential genes. The present invention also provides neutralizing antibodies to proteins encoded by essential genes that bind to and inactivate the essential gene products. The present invention further provides pharmaceutical compositions for treating fungal and proliferative diseases, as well as methods of treatment of fungal and proliferative diseases.

Abstract: The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as targets for highly specific antifungal agents, insecticides, herbicides and anti-proliferation drugs. The present invention provides antisense molecules and ribozymes comprising sequences complementary to the sequences of mRNAs of essential genes that function to inhibit the essential genes. The present invention also provides neutralizing antibodies to proteins encoded by essential genes that bind to and inactivate the essential gene products. The present invention further provides pharmaceutical compositions for treating fungal and proliferative diseases, as well as methods of treatment of fungal and proliferative diseases.

Abstract: An attenuator for a hydraulic control unit of a vehicular braking system includes a hollow cylinder mounted in a bore of a housing. An end cap closes an outer end of the cylinder and does not extend beyond an outer wall of the housing. The cylinder and end cap define an interior chamber having an inner diameter tapered toward the end cap. An orifice is formed in the cylinder to permit fluid to exit the tapered interior chamber. An elastic core piece is fitted into the tapered interior chamber and substantially fills the volume of the chamber. An annular clearance is provided between the core piece and the cylinder. An inlet passage formed in the housing delivers fluid to the chamber. Fluid passes about the core piece to the orifice to reach the an outlet passage formed in the housing. Clearance between the core piece and the cylinder provides a streamlined path for fluid traveling from the inlet passage to the outlet passage, thereby decreasing fluid turbulence and aeration found in prior art attenuators.