Abstract: Computer-implemented systems and methods for rendering a visual effect on a graphical element, including: generating an initial visual effect based on the graphical element; computing a mask shape based on the graphical element; generating a mask based on the mask shape from the graphical element; masking the initial visual effect based on the mask to generate a masked visual effect; and combining the masked visual effect with the graphical element into a combined graphical element and visual effect.

Abstract: A roller head for a skin treatment device configured to drive the roller head by an electro-mechanical mechanism; the roller head comprises a drum and one or more flaps that extend radially from the drum; the one or more flaps comprises a first surface and a second surface and the one or more flaps are configured to flex so that, in use, a first surface of the flap contacts with the skin with when the roller head rotated in a clockwise direction and a second surface of the flap contacts with the skin with when the roller head rotated in an anticlockwise direction.

Abstract: A method can comprise forming a component comprising a first mating surface; coupling the component to an airfoil having a second mating surface and a Field Assisted Sintering Technology (“FAST”) system; heating, via the FAST system, the airfoil and the component; and applying, via the FAST system, a mechanical pressure between the first mating surface and the second mating surface to join the airfoil to the component and form a blade, the component at least partially defining a leading edge of the blade in response to joining the airfoil to the component

Abstract: Various embodiments of apparatuses and methods for an automated machine learning pipeline service and an automated machine learning pipeline generator are described. In some embodiments, the service receives a request from a user to generate a machine learning solution, as well as a dataset that comprises values with different user variable types, and mapping of the user variable types to pre-defined types. The generator can validate the dataset, enrich the values of the dataset using external data sources, transform values of the dataset based on the pre-defined types, train a machine learning model using the enriched and transformed values, and compose an executable package, comprising enrichment recipes, transformation recipes, and the trained machine learning model, that generates scores for other data when executed. The service can further test the executable package using testing data, and provide results of the test to the user.

Abstract: Techniques for an ontology-based approach for modeling service dependencies in a provider network. The approach is flexible and extensible to different provider network SOA systems and not limited to a particular provider network or a particular SOA system. The approach can be used to model an entire SOA system or selected portion thereof and from different perspectives. In some examples, the approach uses an ontology represented using a Web Ontology Language (OWL). In some examples, the ontology is used to identify service dependencies and relationships in a knowledge base that is populated based on operational data collected in the provider network environment.

Abstract: An atomizer for applying a coating includes a nozzle plate, an actuator, and an acoustic focusing device. The nozzle plate defines at least one aperture. The actuator is configured to oscillate to form pressure waves within a fluid to eject the fluid from the nozzle plate. The acoustic focusing device focuses the pressure waves toward the apertures.

Abstract: A component for a vehicle interior may comprise a light guide to allow light transmission from a light source, and a cover to cover the light guide. The light guide may comprise an icon or indicator and the cover may comprise a depression or indentation in an inner surface of the cover. The icon/indicator of the light guide may comprise a light-transmissive resin material configured to fit within the depression/indentation in the cover. The icon/indicator may be presented when illuminated and hidden by the cover when not illuminated. The cover may comprise a polymer material coupled to the light guide. The cover may present a user interface. A surface of the cover may comprise an information region and/or a decorative region. The component may comprise a steering wheel, console, floor console, center console, instrument panel, door panel, dashboard, display, armrest, or cockpit.

Abstract: A user equipment (UE) can be a mobile terminating (MT) device that may receive data from another UE or other network element via a telecommunication network. When a small data payload is available for an MT UE, a base station of the telecommunication network can send a paging message to the UE that includes a Mobile Terminating Small Data Transmission (MT-SDT) paging cause. Based on the MT-SDT paging cause in the paging message, the UE can use Small Data Transmission (SDT) procedures to respond to the paging message. The SDT procedures can allow the UE to obtain the small data payload while the UE remains in a Radio Resource Control (RRC) Inactive state.

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: The present invention relates to the use of hypoxia-inducible factor (HIF) inhibitors in cancer immunotherapy. Specifically, the disclosure provides methods of treating a cancer in a subject in need of cancer immunotherapy, comprising administering a HIF-1a inhibitor to the subject and a second cancer immunotherapeutic agent to the subject, wherein the HIF-1a inhibitor comprising echinomycin, and wherein the second cancer immunotherapeutic agent comprising an anti-CTLA-4 antibody including Ipilimumab or Tremelimumab.

Abstract: System and method for displaying a user interface of an evaluation system configured to evaluate predicted answers generated by a machine learning system. For example, the method includes receiving textual data and a predicted answer to a question associated with a text object. The text object includes a structured data field of the textual data. The predicted answer includes a confidence level. The confidence level is determined by a machine learning system. In response to determining the confidence level being larger than or equal to a predetermined confidence threshold, the predicted answer and a reference is stored in a storage for retrieval and display. The reference indicates a location of the text object in the textual data. In response to determining the confidence level being smaller than the predetermined confidence threshold, the question and the text object associated with the question is displayed.

Abstract: A system and method to match an interface to the face of a user for respiratory therapy. A facial image of the user is stored. Facial features based on the facial image are determined. A database stores facial profiles based on facial features and a corresponding plurality of interfaces. A database stores operational data of respiratory therapy devices with the plurality of corresponding interfaces. A selection engine is coupled to the databases. The selection engine is operative to select an interface for the user from the plurality of corresponding interfaces based on a desired outcome based on the stored operational data and the facial features. The collected data may also be employed to determine whether the selected interface is correctly fitted to the face of the user.

Abstract: Provided is a method including obtaining a set of ontologies mapping n-grams onto concepts to which the n-grams refer in different respective domains of knowledge. The method includes receiving an update associating a first n-gram with a first concept and receiving information by which the update is associated with a given domain of knowledge. The method includes selecting a subset of ontologies by determining that the update in the given domain of knowledge is applicable to respective domains of knowledge of the subset of ontologies and that the first concept has a specified type of relationship to a subset of concepts to which other n-grams are mapped in the subset of ontologies. The method also includes storing, in response to the determination, associations between the first n-gram and the subset of concepts in at least some of the subset of ontologies in memory of the computer system.

Abstract: A surgical instrument is disclosed herein. The surgical instrument can include an end effector that includes jaws configured to transition between an opened condition and a closed condition, a plurality of electrodes positioned within the jaws of the end effector, a control circuit, and a memory configured to store an algorithm configured to cause the control circuit to determine an impedance signal based on signals received from the plurality of electrodes, detect a media positioned between the jaws of the end effector based on the determined impedance signal, determine a position of the detected media based on the received signals, and generate an alert associated with the detected media and the determined position.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: A method of quantifying the effect of peripheral optical errors on patient locomotion includes projecting a pattern on the floor that includes a discrete shapes and empty spaces between the discrete shapes. The method also includes tracking a position of the participant along the pattern as the participant traverses the pattern, and determining foot placement accuracy, utilizing a optical motion capture system and a computer, as the participant walked through the pattern by determining a total area of overlap between the participant's feet and the empty spaces of the pattern. In another embodiment, the method includes arranging obstacles in front of a participant, intermittently displaying a character in front of the participant, determining participant's accuracy in identifying or counting the characters, and determining the participant's step length and foot clearance as the participant steps over the obstacles to quantify the effect of the peripheral optical errors on the participant's locomotion.

Abstract: Systems and methods for a multi-layered peel-away sheath assembly for insertion of a blood pump, the peel-away sheath assembly including a sheath hub and a sheath body having a proximal end that is connected to the sheath hub, and a distal end. The sheath body comprises multiple layers including a reinforcing layer. The reinforcing layer improves flexibility and kink resistance of the assembly The reinforcing layer can comprise LCP, PEBAX, stainless steel, Nitinol, or Kevlar. The reinforcing layer may be a laser-cut hypotube or a braided or coiled filament. A first layer material and a third layer material are thermoplastics, including PEBAX or TPU. The reinforcing layer has at least one discontinuity, which is aligned with peel-away lines in the sheath body to allow an operator to peel-away the assembly. The peel-away lines are formed of inner notches, outer notches, or both. The sheath hub also includes a discontinuity to allow the sheath hub to peel-away.

Abstract: A resin including up to 99.99 weight percent (wt. %) of a first polyolefin grafted with a functional group selected from an ethylenically unsaturated carboxylic acid, a carboxylic acid anhydride, an ester functional group or a combination thereof; and 0.01 to 3.0 wt. % of a tin oxide-based catalyst, where the resin includes 0.2 wt. % to 1.5 wt. % of the functional group from the first polyolefin, the wt. % based on a total weight of the resin. The first polyolefin can be selected from a polyethylene, a polypropylene, an ethylene/alpha-olefin copolymer, a propylene/alpha-olefin copolymer and combinations thereof. The tin oxide-based catalyst can be selected from dibutyltin oxide, dioctyltin oxide and combinations thereof. The resin can be used in a multilayer structure, where a Layer A comprises the resin and a Layer B comprises a polyester, where a first major surface of Layer A is in adhering contact with the second major surface of Layer B.

Abstract: Various embodiments are generally directed to providing authentication and confidentiality mechanisms for message communication over an in-vehicle network. For example, authentication data associated with a communicating node may be transmitted over the network by encoding different predefined voltage levels on top of the message bits of the message being communicated. Different voltage levels may represent different encodings, such as a bit-pair or any bit combination of the authentication data. In a further example, messaging confidentiality between at least two communicating nodes may be achieved by pseudo-randomly flipping, or scrambling, the dominant and recessive voltages of the entire message frame at the analog level based on a pseudo-random control bit sequence.