Abstract: An electronic vapor provision device comprises a body and a vaporizer. The body comprises a power cell and a processor, and the vaporizer is releasably connectable to the body. The processor is configured to enter a sleep mode when the vaporizer is connected to the body and the device is inactive for an inactive time. Furthermore, the processor is configured to leave the sleep mode and enter a usable mode when the vaporizer is disconnected from the body then reconnected to the body.

Abstract: An electronic vapor provision device including a power cell and a vaporizer, wherein the vaporizer includes a heating element, a vaporization cavity, and an airflow channeler, wherein the airflow channeler is situated outside of the vaporization cavity, and wherein the heating element and a heating element support configured to support the heating element are situated within the vaporization cavity.

Abstract: The present invention relates to the treatment of cancer and, in particular to the treatment of patients whose cancer expresses HORMAD1 with an agent that modulates mitotic processes, and diagnostic methods thereof.

Abstract: An electronic vapor provision device including a power cell and a vaporizer, wherein the vaporizer includes a heating element, a vaporization cavity, and an airflow channeler, wherein the airflow channeler is situated outside of the vaporization cavity, and wherein the heating element and a heating element support configured to support the heating element are situated within the vaporization cavity.

Abstract: A cybersecurity engine can guide a forensic investigation of a security incident by estimating the utility of investigating events associated with the security incident, selecting a subset of such events based on the estimated utilities, and presenting data associated with the selected events to the investigator. A method for guiding a response to a security incident may include estimating, for each of a plurality of security events associated with the security incident, a utility of investigating the security event. The method may further include selecting a subset of the security events based, at least in part, on the estimated utilities of investigating the security events. The method may further include guiding the response to the security incident by presenting, to a user, data corresponding to the selected security events.

Abstract: An electronic vapor provision device including a power cell and a computer, wherein the computer includes a computer processor, a memory and an input-output means, and wherein the device further includes a pressure sensor and a temperature sensor.

Abstract: An electronic inhalation device comprising a mouthpiece and a control unit, the control unit comprising a power cell and a computer, where the computer comprises a computer processor, a memory and an input-output means; wherein the device further comprises a transmitter connected to the computer and the computer is configured in use to collect and store use data relating to a user's use of the device in the computer memory and transmit the use data.

Abstract: An electronic inhalation device comprising a mouthpiece and a control unit, the control unit comprising a power cell and a computer, where the computer comprises a computer processor, a memory and an input-output means; wherein the device further comprises a transmitter connected to the computer and the computer is configured in use to collect and store use data relating to a user's use of the device in the computer memory and transmit the use data.

Abstract: The present invention provides an anti-cancer vaccine comprising: (i) at least one peptide comprising the amino acid sequence of a neoantigen encoded by a mutant homologous recombination (HR) DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D, wherein the mutant gene comprises a reversion mutation; and/or (ii) at least one polynucleotide encoding the at least one peptide of (i). Also provided are engineered T cells that recognise said neoantigen. Related methods and medical uses of the vaccine and/or engineered T cell are provided, including for the treatment of cancers, such as homologous recombination (HR) deficient cancers that acquire PARP inhibitor resistance or platinum resistance by development of reversion mutations in an HR DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D.

Abstract: An electronic vapor provision device comprising a power cell and a computer, where the computer comprises a computer processor, a memory and an input-output means; wherein the device further comprises a pressure sensor and a temperature sensor.

Abstract: An electronic vapor provision device comprising a power cell and a vaporizer, wherein the vaporizer comprises a heater and a heater support, wherein the heater is one the inside of the heater support.

Abstract: The present invention relates to an inhaler comprising: an assembly including a heater element arranged in the inhaler to be proximal to a substrate region configured for supporting a vapour or atomiser precursor substrate; wherein the assembly is configured such that the heater element is operative to achieve and maintain a target temperature in the substrate region throughout a period corresponding to a plurality of consecutive uses of the inhaler.

Abstract: An electronic vapor provision device comprising a power cell and a vaporizer, wherein the vaporizer comprises a heater and a heater support, wherein the heater is one the inside of the heater support.

Abstract: The present invention solves some of the problems of the prior art by providing a method, system and apparatus for readily refilling the reservoir of a smoking-substitute device with liquid from a dispenser. The method, system and apparatus of the present invention prevents liquid from being dispensed until the dispenser is securely and sealably engaged to the smoking-substitute device, provides independent liquid and gas pathways between the dispenser and reservoir, and substantially alleviates the problems of spillage and/or leakage when dispensing liquid from the dispenser into the reservoir of the smoking-substitute device.

Abstract: An electronic vapor provision device comprising a power cell, a vaporizer and a liquid store, wherein the vaporizer comprises a heater and a heater support, wherein the liquid store comprises a porous material.

Abstract: An electronic vapor provision system is provided including a pressure drop or air flow sensor for monitoring inhalation by a user through the electronic vapor provision system; and a control unit for detecting the start and end of inhalation based on readings from the sensor. The control unit is configured to monitor the cumulative period of inhalation (Ti) over a predetermined window (Tw); and transfer the electronic vapor provision system to a sleep mode if the cumulative period (Ti) exceeds a predetermined threshold (Th).

Abstract: An electronic vapor provision device comprises a body and a vaporizer. The body comprises a power cell and a processor, and the vaporizer is releasably connectable to the body. The processor is configured to enter a sleep mode when the vaporizer is connected to the body and the device is inactive for an inactive time. Furthermore, the processor is configured to leave the sleep mode and enter a usable mode when the vaporizer is disconnected from the body then reconnected to the body.

Abstract: The present invention relates to a dispenser for dispensing a liquid, comprising: a reservoir for storing a liquid to be dispensed; a manually operative pump arrangement disposed at a first end region of the reservoir; a conduit extending from the pump arrangement to a second end region of the reservoir distal the first end region, the conduit configured for communicating reservoir contents from the second end region to the pump arrangement; a dispense conduit extending from the pump arrangement and comprising a dispense aperture at an end region thereof, the dispense aperture in liquid communication with the pump arrangement; and an open ended tube extending in a direction away from the pump arrangement and configured to surround the dispense conduit, wherein the open ended tube extends to a position such that the open end thereof is at least coterminous with an dispense aperture end of the dispense conduit and actuation of the pump arrangement causes transfer of reservoir contents from the reservoir to the

Abstract: An electronic inhalation device comprising a power cell and a computer. The computer comprises a computer processor, a memory and an input-output means. The computer is configured in use to enter a menu mode when a user activates the menu mode.

Abstract: The present invention relates to a system and assembly for refilling a reservoir with liquid dispensed from a dispenser, in particular, but not exclusively, to a system and assembly for the substantially leak-free refilling of the reservoir of a smoking-substitute device with a liquid comprising nicotine from a refill dispenser. The assembly is configured to provide a gas communication pathway through the assembly and physically separate from the liquid communication pathway for venting gas from an end of the assembly proximal the first aperture to an exterior of the assembly responsive to the movement of the assembly to the secured and open configuration, the assembly configured to close the gas communication pathway in the unsecured and closed configuration.