Abstract: A method of improving accessibility for the user operation of a first application on a computer includes the steps of taking one or more measurements of a current user's interaction with an application on the computer, comparing the one or more measurements with expectations derived from measurements from a first corpus of users, characterising one or more needs of the current user based upon the comparison, and modifying at least a first property of the first application responsive to the characterised need or needs.

Abstract: An orchestration system of or otherwise available to a web platform centralizes the execution of workflow components of a workflow associated with a job posting hosted by the web platform using various software services internal and/or external to the web platform. The workflow components and attributes thereof are determined based on the job posting. Domain-specific language (DSL) instructions for the various workflow components are generated. First DSL instructions are invoked by the orchestration system to cause an execution of a first workflow component of the workflow by a first software service. The orchestration system obtains an output of the first workflow component, such as values of relevant attributes, and, based on the output and in some cases information derived other than from the first workflow component, invokes next DSL instructions to cause an execution of a next workflow component of the workflow by another software service.

Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: An apparatus, for assisting at least a first user in communicating with one or more other users via a network, includes: a storage unit configured to store: phrase data corresponding to one or more phrases, where each phrase comprises one or more words, tag data corresponding to one or more tags, where each tag comprises at least part of one word, and first association data corresponding to one or more associations between one or more of the phrases and one or more of the tags; an input unit configured to receive one or more audio signals from the at least first user; a recognition unit configured to recognise one or more spoken words included within the received audio signals; an evaluation unit configured to evaluate whether a given recognised spoken word corresponds to a given tag; and if so, a transmission unit configured to transmit one or more of the phrases associated with the given tag to one or more of the other users.

Abstract: The present disclosure relates to biosensors and methods of use thereof.

Abstract: A steering system may include a seat assembly, a frame assembly and a wheel. The frame assembly may include a steering tube that is rotatably disposed within a head tube with a cam at a top end and a pair of forks at a bottom end to which is coupled an axle of the wheel. An arm may be disposed on and rotatably coupled to the seat assembly, and rotatably coupled to a left armrest and right armrest. A steering rod may be coupled to the cam and to one of the arms, the left armrest or the right armrest, such that forward movement of one of the armrests causes the steering rod to be translated forward and the cam to rotate in one direction, and backward movement of the same armrest causes the steering rod to be translated backward and the cam to rotate in an opposite direction.

Abstract: A steering system may include a seat assembly, a frame assembly and a wheel. The frame assembly may include a steering tube that is rotatably disposed within a head tube with a cam at a top end and a pair of forks at a bottom end to which is coupled an axle of the wheel. An arm may be disposed on and rotatably coupled to the seat assembly, and rotatably coupled to a left armrest and right armrest. A steering rod may be coupled to the cam and to one of the arms, the left armrest or the right armrest, such that forward movement of one of the armrests causes the steering rod to be translated forward and the cam to rotate in one direction, and backward movement of the same armrest causes the steering rod to be translated backward and the cam to rotate in an opposite direction.

Abstract: A valve assembly for an exhaust gas recirculation system includes a housing defining an inlet bore and including a second interior surface defining a housing bore. The valve assembly also includes a valve seat and a valve. The valve includes a valve stem and a valve sealing member. The valve assembly optionally includes a baffle at least partially disposed in the housing bore. A first interior radius is defined between the valve stem and the second interior surface. A second interior radius is defined between at least one of the valve stem and the second interior surface, the valve stem and the baffle, and the baffle and the second interior surface. The second interior radius is different from the first interior radius and is configured to direct the flow of the exhaust gas in the housing bore to reduce swirl of exhaust gas in the housing bore.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Disclosed herein are DNA origami nanostmcture that can be functionalized for personalized and targeted drug delivery. The disclosed nanostructures enter cells through the endolysosomal pathway and circumvent drug resistance mechanisms in target cells. The disclosed nanostructures can be loaded small molecule drugs (e.g. anthracyclines, anti-metabolites) and nucleic acids (e.g. antisense oligonucleotides, siRNA, miRNA) with targeting and/or therapeutic antibodies against tumor-specific antigens (e.g. anti-CD33, anti-CD20) that can be modified to treat to a wide range of cancers and ultimately tailored to specific patients' needs for precision medicine.

Abstract: Apparatus including a robotically controlled end effector having a compliant nosepiece that forms plies of a material onto contoured surfaces of a tool. The end effector includes a plurality of individually controllable rotary actuators which respectively control the position and compliancy of individual sections of the nosepiece in order to better conform the plies the contoured tool surfaces.

Abstract: Methods for performing inference on a generative model are provided. In one aspect, a method includes receiving a generative model in a probabilistic program form defining variables and probabilistic relationships between variables, and producing a neural network to model the behaviour of the generative model. The input layer includes nodes corresponding to the variables of the generative model, and the output layer includes nodes corresponding to a parameter of the conditional marginal of the variables of the input layer. The method also includes training the neural network using samples from the probabilistic program. A loss function is provided for each node of the output layer. The loss function for each output node is independent of the loss functions for the other nodes of the output layer. The method also includes performing amortised inference on the generative model. Systems and machine-readable media are also provided.

Abstract: Apparatus for forming composite plies on a contoured tool includes a forming head for forming the composite plies on the tool. The forming head is mounted on a manipulator and includes a compliant nosepiece adapted to conform to the contoured tool.

Abstract: R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.

Abstract: Apparatus including a robotically controlled end effector having a compliant nosepiece that forms plies of a material onto contoured surfaces of a tool. The end effector includes a plurality of individually controllable rotary actuators which respectively control the position and compliancy of individual sections of the nosepiece in order to better conform the plies the contoured tool surfaces.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.

Abstract: Methods for providing a computer implemented medical diagnosis are provided. In one aspect, a method includes receiving an input from a user comprising at least one symptom of the user, and providing the at least one symptom as an input to a medical model. The method also includes deriving estimates of the probability of the user having a disease from the discriminative model, inputting the estimates to the inference engine, performing approximate inference on the probabilistic graphical model to obtain a prediction of the probability that the user has that disease, and outputting the probability of the user having the disease for display by a display device.