Abstract: The present disclosure provides improved compositions for the homology directed repair of the human globin locus for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.

Abstract: The present disclosure provides improved compositions for the homology directed repair of the human globin locus for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy.

Abstract: A method, computer readable medium, and system are disclosed for supersampling a large-scale and disjoined data set. The data set may include point cloud, voxel, or polygonal mesh data. The data set may be rendered using a distributed, sort-last rendering system that includes a plurality of rendering nodes and one or more compositing nodes. The method includes the steps of receiving graphics data at a plurality of rendering nodes, rendering at least a portion of the graphics data by one or more rendering nodes to produce multi-sample image data, encoding the multi-sample image data using a difference encoding technique, and transmitting the encoded multi-sample image data to a compositing node. The multi-sample image data comprises a plurality of values per pixel of a target image corresponding to a plurality of sample locations defined for each pixel of the target image.

Abstract: A method, computer readable medium, and system are disclosed for supersampling a large-scale and disjoined data set. The data set may include point cloud, voxel, or polygonal mesh data. The data set may be rendered using a distributed, sort-last rendering system that includes a plurality of rendering nodes and one or more compositing nodes. The method includes the steps of receiving graphics data at a plurality of rendering nodes, rendering at least a portion of the graphics data by one or more rendering nodes to produce multi-sample image data, encoding the multi-sample image data using a difference encoding technique, and transmitting the encoded multi-sample image data to a compositing node. The multi-sample image data comprises a plurality of values per pixel of a target image corresponding to a plurality of sample locations defined for each pixel of the target image.

Abstract: An engraving holder (15) comprising a tray (16) adapted to be engaged by an engraving machine (18) and comprising at least one recess (19), the recess containing a mold (20), the mold comprising a cavity (21) adapted to hold an engraveable item (22) and having an inner surface (23) conforming to the shape of at least a portion of the outer surface (45) of the engraveable item. The tray may comprise multiple recesses containing multiple molds and the molds may have multiple cavities and the inner surfaces of the cavities may be of different shapes. The tray may have a recess that is defined by a bottom surface (24) and a side surface (32) extending from the bottom surface and may further comprise a notch (37) extending into the tray from the side surface. The notch (38a, 34e) may extend between the side surfaces (32a and 25e) of at least two recesses (19a and 19e) of the tray. The mold may be vulcanized rubber and the device may further comprise a jewelry item positioned in the cavity and an engraving machine.