Abstract: A method for manufacturing cobalt complexes having the formula:[Co(NH.sub.3).sub.5 M]T.sub.ywherein M ligands are selected from substituted and unsubstituted C.sub.1 -C.sub.30 carboxylic acids having the formulas:RC(O)O--;said method comprising reacting cobalt (II) complexes having the formula [Co(H.sub.2 O).sub.6 ] T.sub.y (e.g., T is chloride) with concentrated ammonium hydroxide/ammonium chloride, followed by an oxidizing agent (e.g., peroxide), followed by carboxylic acid anhydride of the formula RC(O)O(O)CR.

Abstract: Pharmaceutical compositions, useful for treating abnormal calcium and phosphate metabolism, which contain geminal-diphosphonic acid compounds; and a method of treating diseases characterized by abnormal calcium and phosphate metabolism utilizing these pharmaceutical compositions.

Abstract: A method for manufacturing cobalt complexes having the formula:[Co(NH.sub.3).sub.5 M]T.sub.ywherein M ligands are selected from substituted and unsubstituted C.sub.1 -C.sub.30 carboxylic acids having the formulas:RC(O)O--;said method comprising reacting cobalt complexes having the formula [Co(NH.sub.3).sub.5 X]T.sub.y (e.g., X is chlorine) with concentrated ammonium hydroxide followed by carboxylic acid anhydride of the formula RC(O)O(O)CR.

Abstract: Detergent compositions containing conventional detergent surfactants, detergent builders, and the like, and a chelant selected from ethylenediamine-N,N'-diglutaric acid (EDDG) and 2-hydroxypropylenediamine-N,N'-disuccinic acid (HPDDS) are disclosed. Such compositions provide enhanced removal of organic stains, such as food and beverage stains. The EDDG and HPDDS are biodegradable and contain no phorphorus.

Abstract: Disclosed are the N,N'-(1-oxo-1,2-ethanediyl)-bisaspartates comprising the moiety ##STR1## methods for their preparation (including an unexpected preparation from glyoxal bisulfite and aspartic acid in concentrated aqueous alkaline media) and useful compositions containing the same; illustrative are general-purpose sequestrant compositions, chelating agent compositions for transition metals such as iron, manganese and copper, general-purpose laundry detergent compositions and detergent compositions comprising perborate bleach, a bleach activator and, as a bleach stabilizer/performance enhancer, the novel bisaspartates. These unique nonphosphorus compounds are useful at low levels and differ from traditional --N--C--C--N-- chelating agents such as ethylenediaminetetraacetates by the presence of one amino- and one amido- functional group which it is believed will provide additional advantages, such as improved biodegradation.

Abstract: Methods of treating non-inflammatory diseases characterized by abnormal calcium and phosphate metabolism comprising administering a pharmaceutical composition comprising a geminal diphosphonic acid compound in which the diphosphonic acid-containing carbon is linker via a sulfur atom or a sulfur-containing chain to a 6-membered aromatic ring containing one or more nitrogen atoms.

Abstract: Laundry detergent compositions containing a detergent surfactant, a detergent builder, and from about 0.1% to about 10% by weight ethylenediamine-N,N'-disuccinic acid or salts thereof are disclosed. These compositions provide enhanced removal of organic stains, such as food and beverage stains.