Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: A system obtains a script containing at least one transaction to be performed with the web site, the at least one transaction defining a sequence of page requests identifying at least one web page to obtain from the web site. The system executes the script to perform the at least one transaction, performance of the at least one transaction including retrieving the sequence of the at least one web page. The system detects a capture event associated with the at least one web page, and in response to the capture event, captures content of the at least one web page. The system packages the content of the at least one web page into a container capable of being rendered, such that the container provides a plurality of components associated with the at least one captured web page, and delivers the container to a repository.

Abstract: A system provides an agent that executes remotely from a web site and can measure performance associated with the web site. The agent obtains a script containing at least one transaction to be performed with the web site. The transaction(s) define a sequence of page requests identifying web pages to obtain from the web site. The agent executes the script to perform the transaction with the web site. Performance of the transaction includes retrieving the sequence of web pages and identifying respective performance metrics including performance metrics associated with obtaining respective objects defined within each web page, and performance metrics associated with obtaining a complete version of each web page. The agent transmits the performance metrics associated with execution of the transaction defined by the script to a repository.

Abstract: A system obtains a script containing at least one transaction to be performed with the web site, the at least one transaction defining a sequence of page requests identifying at least one web page to obtain from the web site. The system executes the script to perform the at least one transaction, performance of the at least one transaction including retrieving the sequence of the at least one web page. The system detects a capture event associated with the at least one web page, and in response to the capture event, captures content of the at least one web page. The system packages the content of the at least one web page into a container capable of being rendered, such that the container provides a plurality of components associated with the at least one captured web page, and delivers the container to a repository.

Abstract: A system obtains a script containing at least one transaction to be performed with the web site, the at least one transaction defining a sequence of page requests identifying at least one web page to obtain from the web site. The system executes the script to perform the at least one transaction, performance of the at least one transaction including retrieving the sequence of the at least one web page. The system detects a capture event associated with the at least one web page, and in response to the capture event, captures content of the at least one web page. The system packages the content of the at least one web page into a container capable of being rendered, such that the container provides a plurality of components associated with the at least one captured web page, and delivers the container to a repository.

Abstract: A method and system to deposit rapidly, accurately and efficiently liquid droplets onto a sample plate. A liquid from which the droplet is formed contains sample molecules, matrix molecules or a mixture of both sample and matrix molecules. A sample plate is positioned with respect to a position below a portion of the liquid, such as a droplet. A power supply forms an electric field between the sample plate and the liquid, which pulls the droplet to a target location on the sample plate. A plurality of capillary columns is provided for simultaneous or successive multiple depositions via application of one or more high voltage pulses between the liquid sample array and a sample plate.

Abstract: This invention provides capacity altering devices that facilitate the processing of samples whose volume exceeds the capacity of external sample processing regions (e.g., sample tubes or wells). The invention also provides holders that can be used with such devices, e.g., to allow centrifugation of the devices and/or to minimize handling of the external processing regions. Methods of processing samples, particularly samples whose volume exceeds the capacity of the external processing regions, and methods of collecting compounds in external processing regions are another feature of the invention.

Abstract: This invention provides capacity altering devices that facilitate the processing of samples whose volume exceeds the capacity of external sample processing regions (e.g., sample tubes or wells). The invention also provides holders that can be used with such devices, e.g., to allow centrifugation of the devices and/or to minimize handling of the external processing regions. Methods of processing samples, particularly samples whose volume exceeds the capacity of the external processing regions, and methods of collecting compounds in external processing regions are another feature of the invention.

Abstract: A method and system to deposit rapidly, accurately and efficiently liquid droplets onto a sample plate. A liquid from which the droplet is formed contains sample molecules, matrix molecules or a mixture of both sample and matrix molecules. A sample plate is positioned with respect to a position below a portion of the liquid, such as a droplet. A power supply forms an electric field between the sample plate and the liquid, which pulls the droplet to a target location on the sample plate. A plurality of capillary columns is provided for simultaneous or successive multiple depositions via application of one or more high voltage pulses between the liquid sample array and a sample plate.

Abstract: This invention provides capacity altering devices that facilitate the processing of samples whose volume exceeds the capacity of external sample processing regions (e.g., sample tubes or wells). The invention also provides holders that can be used with such devices, e.g., to allow centrifugation of the devices and/or to minimize handling of the external processing regions. Methods of processing samples, particularly samples whose volume exceeds the capacity of the external processing regions, and methods of collecting compounds in external processing regions are another feature of the invention.

Abstract: An automated centrifuge comprising a rotor having a plurality of cavities located in the rotor. A tube is structured to be insertable into any one of the cavities and a controller is configured to insert the tube into the cavity. The cavities located in the rotor are grouped in clusters, and the cavities of each cluster are substantially parallel.

Abstract: An automated centrifuge comprising a rotor having a plurality of sample receiving elements located in the rotor is provided. Sample processing components are structured to be insertable into any one of the receiving elements and a controller is configured to insert the sample processing components into the sample receiving elements. The sample receiving elements located in the rotor are grouped in clusters, and the cavities of each cluster are substantially parallel. Also, an automated centrifuge system comprising a rotor including a plurality of clusters of receiving elements, each element including a longitudinal axis, with the longitudinal axes of each element in a cluster being substantially parallel is provided. A plurality of sample processing components are arranged in groups, with each group configured to be received into adjacent clusters. A rotor position member is structured to determine the position of each cluster.

Abstract: A method and system to deposit rapidly, accurately and efficiently liquid droplets onto a sample plate. A liquid from which the droplet is formed contains sample molecules, matrix molecules or a mixture of both sample and matrix molecules. A sample plate is positioned with respect to a position below a portion of the liquid, such as a droplet. A power supply forms an electric field between the sample plate and the liquid, which pulls the droplet to a target location on the sample plate. A plurality of capillary columns is provided for simultaneous or successive multiple depositions via application of one or more high voltage pulses between the liquid sample array and a sample plate.