Abstract: Provided herein are methods and compositions for site-specific conjugation of antibodies in the presence of a transglutaminase.

Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: Systems and methods are described for denoising, or filtering out, unwanted noise or interference, from biological or physiological parameter signals or waveforms such as ECG signals caused by application of electromagnetic energy (e.g., electrical stimulation) in a vicinity of sensors configured to obtain the biological or physiological parameter signals.

Abstract: A method of selecting a combination of electrodes for use in neurostimulation includes testing combinations of electrodes in an electrode array to identify an atrial capture. The atrial capture is indicated by at least one effect on an atrium. The method includes excluding electrodes with the atrial capture to result in remaining electrodes of the electrode array, testing combinations of the remaining electrodes of the electrode array for effect on cardiac contractility and/or relaxation, and selecting a combination of electrodes from the remaining electrodes. The selected combination has both a desired effect on cardiac contractility and/or relaxation and does not have an undesired side effect.

Abstract: A semiconductor device including an integrated circuit where the integrated circuit includes one or more layers forming electronic elements on a substrate of semiconductor material. A first layer includes a superconducting niobium trace connected to at least one of the electronic elements and a second layer includes superconducting niobium nitride positioned adjacent to a portion of the niobium trace.

Abstract: Systems and methods are described for denoising, or filtering out, unwanted noise or interference, from biological or physiological parameter signals or waveforms such as ECG signals caused by application of electromagnetic energy (e.g., electrical stimulation) in a vicinity of sensors configured to obtain the biological or physiological parameter signals.

Abstract: A method performed by an electronic device includes retrieving, from a first computing environment, a first set of structured documents that contains metadata for a first version of a workflow to be performed by a workflow engine, the first version of the workflow including a first set of workflow elements. The method further including retrieving, from a second computing environment, a second set of structured documents. The method determines whether a rule is to be applied, based on one but not both of the first and second sets of structured documents including at least one section for a workflow element having a type to which the rule applies, and generating a description of a change in the second version of the workflow relative to the first version of the workflow.

Abstract: Techniques are disclosed relating to an apparatus that includes a plurality of execution pipelines including first and second execution pipelines, a shared circuit that is shared by the first and second execution pipelines, and a decode circuit. The first and second execution pipelines are configured to concurrently perform operations for respective instructions. The decode circuit is configured to assign a first program thread to the first execution pipeline and a second program thread to the second execution pipeline. In response to determining that respective instructions from the first and second program threads that utilize the shared circuit are concurrently available for dispatch, the decode circuit is further configured to select between the first program thread and the second program thread.

Abstract: A method performed by an electronic device includes retrieving, from a first computing environment, a first set of structured documents that contains metadata for a first version of a workflow to be performed by a workflow engine, the first version of the workflow including a first set of workflow elements. The method further including retrieving, from a second computing environment, a second set of structured documents. The method determines whether a rule is to be applied, based on one but not both of the first and second sets of structured documents including at least one section for a workflow element having a type to which the rule applies, and generating a description of a change in the second version of the workflow relative to the first version of the workflow.

Abstract: Techniques are disclosed relating to an apparatus that includes a plurality of execution pipelines including first and second execution pipelines, a shared circuit that is shared by the first and second execution pipelines, and a decode circuit. The first and second execution pipelines are configured to concurrently perform operations for respective instructions. The decode circuit is configured to assign a first program thread to the first execution pipeline and a second program thread to the second execution pipeline. In response to determining that respective instructions from the first and second program threads that utilize the shared circuit are concurrently available for dispatch, the decode circuit is further configured to select between the first program thread and the second program thread.

Abstract: Systems and methods are described for denoising, or filtering out, unwanted noise or interference, from biological or physiological parameter signals or waveforms such as ECG signals caused by application of electromagnetic energy (e.g., electrical stimulation) in a vicinity of sensors configured to obtain the biological or physiological parameter signals.

Abstract: Techniques and architectures for creating scratch organizations in a multitenant environment. A scratch organization defined by metadata corresponding to a subject organization is generated. The metadata defines at least a set of privileges for the subject organization to be replicated in the scratch organization. Test data is loaded from a test source that is not the subject organization. Changes to the subject organization are not applied to the scratch organization after creation of the scratch organization and changes to the scratch organization are not applied to the subject organization. One or more test operations are performed on the scratch organization using the loaded test data. The scratch organization is destroyed after the one or more test operations have been performed.

Abstract: A method performed by an electronic device includes retrieving, from a first computing environment, a first set of structured documents that contains metadata for a first version of a workflow to be performed by a workflow engine, the first version of the workflow including a first set of workflow elements. The method further including retrieving, from a second computing environment, a second set of structured documents. The method determines whether a rule is to be applied, based on one but not both of the first and second sets of structured documents including at least one section for a workflow element having a type to which the rule applies, and generating a description of a change in the second version of the workflow relative to the first version of the workflow.

Abstract: Control circuitry coupled to a multiply unit which includes a plurality of stage, each of which may be configured to perform a corresponding arithmetic function, may be configured to retrieve a given entry from a lookup table dependent upon a first portion of a binary representation of an input operand. An error value of an error function evaluated dependent upon a lookup value in a given entry of the plurality of entries is included in a predetermined error range. The control circuitry may be further configured to determine an initial approximation of a result of an iterative arithmetic operation using the first entry and initiate the iterative arithmetic operation using the initial approximation and the input operand.

Abstract: A vehicle accessory control circuit includes a processor electrically connected to a power source and a memory, the processor executing computer readable instructions stored on the memory to configure the accessory control circuit and an accessory control output. The control circuit includes at least one capacitive touch assembly having an electrically conductive conduit shielded by a portion of a steering mechanism of the vehicle. The capacitive touch assembly is connected to the power source and the processor such that the conduit is configured to transmit a capacitance input data signal to the processor to adjust the accessory control output. The capacitance input data signal is varied by a conductive touch object such as a human finger or palm to manipulate the output from the accessory system.

Abstract: A multiplier unit may be configured to generate a final approximation of an iterative arithmetic operation performed on two operands. Circuitry coupled to the multiplier unit may perform a shift operation and a mask operation on the final approximation to generate shifted and un-shifted approximations, respectively. The circuitry may generate a first remainder using the un-shifted approximation and a sign value of a second remainder using the first remainder. Using the sign value of the second remainder, the circuitry may perform a rounding operation on the shifted approximation to generate a final answer.

Abstract: An electronically scanned array (ESA) is configured for a high-degree of isolation between adjacent radiating elements and between co-located ports. Radiating elements of the ESA include a centrally located slot-aperture configured as a radiating source, and multiple via-apertures positioned around and between each port of the co-located ports. An amount of metamaterial structures found in a unit cell of an antenna layer ascendingly increases from a bottom antenna layer to a top antenna layer, with groups of metamaterial structures differing in orientation with respect to unit cells of two or more antenna layers and with respect to two groups found within a unit cell of the top antenna layer.

Abstract: A system that for storing program counter values is disclosed. The system may include a program counter, a first memory including a plurality of sectors, a first circuit configured to retrieve a program instruction from a location in memory dependent upon a value of the program counter, send the value of the program counter to an array for storage and determination a predicted outcome of the program instruction in response to a determination that execution of the program instruction changes a program flow. The second circuit may be configured to retrieve the value of the program counter from a given entry in a particular sector of the array, and determine an actual outcome of the program instruction dependent upon the retrieved value of the program counter.

Abstract: In various embodiments, a method of implementing a local simulation environment may be performed. The method may include implementing a network-based computing platform that executes applications received from a plurality of clients. The network-based computing platform may include a network-based software development environment. The method may further include providing a local simulation environment to a client. The local simulation environment may constitute a subset of the functionality of the network-based software development environment. The local simulation environment may prevent the client from accessing administrator features of the local simulation environment. The method may further include receiving, from the client, an application executable on the network-based computing platform.

Abstract: Techniques and architectures for creating scratch organizations in a multitenant environment. A scratch organization defined by metadata corresponding to a subject organization is generated. The metadata defines at least a set of privileges for the subject organization to be replicated in the scratch organization. Test data is loaded from a test source that is not the subject organization. Changes to the subject organization are not applied to the scratch organization after creation of the scratch organization and changes to the scratch organization are not applied to the subject organization. One or more test operations are performed on the scratch organization using the loaded test data. The scratch organization is destroyed after the one or more test operations have been performed.