Patents by Inventor Christopher R. Sclimenti

Christopher R. Sclimenti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Altered Recombinases for Genome Modification
    Publication number: 20100190178
    Abstract: The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.
    Type: Application
    Filed: April 9, 2010
    Publication date: July 29, 2010
    Inventors: MICHELE P. CALOS, Christopher R. Sclimenti
  • Altered Recombinases for Genome Modification
    Publication number: 20080167261
    Abstract: The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 10, 2008
    Inventor: Christopher R. Sclimenti
  • Altered recombinases for genome modification
    Publication number: 20020094516
    Abstract: The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also includes methods of modifying the genomes of cells using the altered recombinases, including methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell.
    Type: Application
    Filed: February 16, 2001
    Publication date: July 18, 2002
    Inventors: Michele P. Calos, Christopher R. Sclimenti