Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: A disconnector device including an isolator connected between a first terminal and to a second terminal, and a sleeve positioned around the isolator and moveable between an un-extended position prior to the isolator operating and an extended position after the isolator operates, the sleeve being configured to trap debris produced by operation of the isolator.

Abstract: Reduced-size user interfaces for providing weather information are disclosed. At an electronic device with a touch-sensitive display, indications of a location and a temperature at the location may be displayed. In some examples, a user may provide input through a touch on the touch-sensitive display and/or through a rotation of a rotatable input mechanism to display additional weather information, such as weather information for another location, another temperature, another time, and so forth. In some examples, the device may obtain data representing an upcoming activity, determine whether the activity is to begin within a threshold amount of time, and display weather information based on the upcoming activity. In some examples, the device may display an affordance at a position to indicate the time of day for which a weather condition is provided.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant A.AV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: A method for providing control data for a generative layer construction device includes accessing layer data records that have data models of buildup material layers to be selectively solidified, where a base surface region of an object cross section exists in at least one layer data record, where in at least one of p layers below the base surface region, no solidification of buildup material is specified. The method further includes changing the layer data record such that a temporal sequence for scanning the associated object cross section with energy radiation is specified such that at least one portion of the base surface region is scanned before all other parts of the object cross section; and a third step, where the changed layer data record is provided for the generation of a control data record for the device.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: The invention relates to a device (10) for pulling in, and in particular curing, a pipeline liner (40), the device comprising a housing (11) having a first end piece (12) and a second end piece (14) opposite one another, a housing body (16) extending between the end pieces (12, 14), and a power supply line connected to the first end piece (12), in which device an electromagnet (45) which is coupled to the power supply line and can be energized thereby is provided on the second end piece (14), in particular on the free end face thereof.

Abstract: The invention relates to a device (10) lot curing a pipeline lining, wherein the pipeline lining comprises a resin which is curable by means of electromagnetic radiation of a specified wavelength or of a specified wavelength range, comprising a housing (11) with a first (12) and a second (14) opposite end piece and with a housing body (16) which extends between the end pieces (12, 14) and with an electrical current and cooling fluid feed line which is connected to die first end piece (12), wherein the housing body (16) has radially extending arms (26), on the outer end surfaces of which here is arranged in each case at least one light-emitting diode (28), which light-emitting diodes emit light of the specified wavelength or of the specified wavelength range and are connected to the electrical current feed line, and wherein, between the arms (26), the housing (10) has cooling fluid passage openings (32) which are coupled to the cooling fluid feed line and which extend in a longitudinal direction at least in ce

Abstract: A disconnector device including an isolator connected between a first terminal and to a second terminal, and a sleeve positioned around the isolator and moveable between an un-extended position prior to the isolator operating and an extended position after the isolator operates, the sleeve being configured to trap debris produced by operation of the isolator.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: A disconnector device including an isolator connected between a first terminal and to a second terminal, and a sleeve positioned around the isolator and moveable between an un-extended position prior to the isolator operating and an extended position after the isolator operates, the sleeve being configured to trap debris produced by operation of the isolator.

Abstract: A method for providing control data for a generative layer construction device has a first step of accessing a data record which, at least for a partial region of an object cross section, specifies in which temporal sequence an energy beam bundle is to be moved in scanning lines over the places of this partial region to scan the buildup material. In a second step, the data record is changed such that in at least one of the layers for the respective partial region of an object cross-section, a check is carried out to determine whether the scan time required to scan the buildup material along a scanning line falls below a predefined minimum duration tmin and either a lower energy density of the energy beam bundle during scanning of the buildup material along this scanning line is specified and/or a wait time is specified before the energy beam bundle is moved along a further scanning line.

Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.

Abstract: A method for providing control data for a generative layer construction device includes accessing layer data records that have data models of buildup material layers to be selectively solidified, where a base surface region of an object cross section exists in at least one layer data record, where in at least one of p layers below the base surface region, no solidification of buildup material is specified. The method further includes changing the layer data record such that a temporal sequence for scanning the associated object cross section with energy radiation is specified such that at least one portion of the base surface region is scanned before all other parts of the object cross section; and a third step, where the changed layer data record is provided for the generation of a control data record for the device.

Abstract: A disconnector device including an isolator connected between a first terminal and to a second terminal, and a sleeve positioned around the isolator and moveable between an un-extended position prior to the isolator operating and an extended position after the isolator operates, the sleeve being configured to trap debris produced by operation of the isolator.

Abstract: A method for providing control data for a generative layer construction device has a first step of accessing a data record which, at least for a partial region of an object cross section, specifies in which temporal sequence an energy beam bundle is to be moved in scanning lines over the places of this partial region to scan the buildup material. In a second step, the data record is changed such that in at least one of the layers for the respective partial region of an object cross-section, a check is carried out to determine whether the scan time required to scan the buildup material along a scanning line falls below a predefined minimum duration tmin and either a lower energy density of the energy beam bundle during scanning of the buildup material along this scanning line is specified and/or a wait time is specified before the energy beam bundle is moved along a further scanning line.

Abstract: The invention concerns an optical monitoring system for the measurement of layer thicknesses of thin coatings applied in a vacuum, particularly on moving substrates, during the coating process, in which the light intensity of the light of a light source injected into a reference light guide and released by a first piezoelectric or electrostrictive or magnetostrictive light chopper is registered by a light detector unit in a reference phase, the light of the light source in a measuring phase is injected into a first measuring light guide and the light released by a second piezoelectric or electrostrictive or magnetostrictive light chopper is directed to the substrate, and the light intensity of the light reflected or transmitted from the substrate is registered by the light detector unit through a second measuring light guide, and a remaining light intensity is registered by the light detector unit in at least one dark phase, wherein the reference phase, the measuring phase, and the dark phase are shifted in t

Abstract: A safety closure for a beverage container that prevents an infant from ingesting the closure is provided. The closure includes a cylindrical cap body to be released securely into a beverage container. The cap body includes lateral projections extending from the cylindrical cap are sufficient to prevent an infant from ingesting the cap. The projections are provided to also facilitate rotation of the cap and to be releasably secure the cap of the container.