Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable and dispersible. The products generally have a Slosh time less than 2 minutes, such as less than about 60 seconds, such as less than about 45 seconds. Surprisingly, the foregoing Slosh times are achieved despite the tissue products having relatively high cross-machine direction (CD) wet tensile strength, such as greater than about 100 g/3?. Typically, increasing wet tensile strength, particularly wet CD tensile strength, negatively effects dispersability and increases Slosh time. Despite this trend, the present invention surprisingly provides a tissue product having a relatively high degree of wet strength and good dispersability.

Abstract: A cuffed tracheal tube has a shaft (10) with an inner component (30) having an inflation lumen (23) extending along a rib (33) along the outside of the component. The rib (33) terminates a short distance rearwardly of the patient end (14) of the inner component. The inflation lumen (23) is closed by an outer layer (51) applied over the inner component (30) and covering the patient end of the rib. Two closely spaced openings (54) through the rib (33) are spaced in the inflatable region of a silicone sealing cuff (13) secured around the patient end of the shaft.

Abstract: The creped multi-ply tissue products are durable, smooth and have low levels of Slough. In certain instances, the creped multi-ply tissue products are produced using a creping composition comprising a non-crosslinked latex polymer. The creped multi-ply tissue products may have a geometric mean tensile (GMT) from about 700 to about 1,500 g/3?, a basis weight from about 45 to about 60 gsm and a Slough less than about 2.00 mg, such as from about 0.10 to about 2.00 mg. The inventive tissue products also have good durability, such as a Durability Index from about 10.0 to about 20.0, smooth surfaces, such as a TS750 value from about 15.0 to 40.0 and low stiffness, such as a Stiffness Index less than about 10.0.

Abstract: Embodiments of the present disclosure provide to techniques for automatically grouping software applications based on their technical patterns/characteristics (i.e., technical facets) via machine learning (ML) algorithms. For instance, a first set of software applications that exhibit a high prevalence of one or more first technical facets may be grouped into a first category, a second set of software applications that exhibit a high prevalence of one or more second technical facets may be grouped into a second category, and so on. Once grouped into categories, the software applications in a given category may be assessed, analyzed, and/or processed together for various purposes.

Abstract: The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential antimicrobial activity. In some embodiments, the antimicrobial activity is facilitated via interaction with the lipid bilayer of the parasitic cell form, leading to membrane pore formation and resulting in cell lysis. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites was shown in vitro using a sporozoite killing assay.

Abstract: A closure having a first flange with first engagement mechanism and a second with a second engagement mechanism disposed between the first end and the second end. The first engagement mechanism configured to engage the second engagement mechanism. A slider configured to selectively engage the first engagement mechanism and the second mechanism when moved in a first direction and disengage the first engagement mechanism from the second engagement mechanism when moved in a second direction. The closure is substantially watertight in the closed position.

Abstract: A battery pack assembly includes a first cell stack having a first side and a second side. The first side is transverse to the second side. A second cell stack is adjacent the first side of first cell stack. A divider has a barrier portion and an attachment portion. The barrier portion is disposed between the first side of the first cell stack and the second cell stack. The attachment portion is secured directly to the second side of the first cell stack.

Abstract: According to an example, a method comprises receiving a first audio stream from an input device, detecting presence within the first audio stream of at least an acoustic pattern, executing at least one corrective action over a portion of data of the first audio stream including the acoustic pattern such that a second audio stream is obtained, and transmitting the second audio stream to an output device.

Abstract: A tool has a first gripping portion or arm and a second gripping portion or arm hingedly connected to the first gripping portion. The first and second gripping portions define a cable space therebetween sized to receive a cable. A first lever arm and a second lever arm extend from the first gripping portion and the second gripping portion, respectively. A flexure is arranged between the first lever arm and the second lever arm and biases the first and second lever arms into a predetermined position.

Abstract: A system includes an aftertreatment system heater of an exhaust aftertreatment system coupled to an engine A controller coupled to the aftertreatment system heater is configured to determine a condition of an exhaust gas from an engine and compare the condition to a predefined threshold. If the condition of the exhaust gas does not meet the predefined threshold, the controller is configured to determine whether an engine operating condition is met for activating a cylinder deactivation operating mode for the engine. If the engine operating condition is met, the controller is configured to operate the engine in the cylinder deactivation operating mode by deactivating a cylinder of a plurality of cylinders. If the engine operating condition is not met, the controller is configured to activate the aftertreatment system heater to heat the exhaust gas.

Abstract: Methods for depositing a molybdenum nitride film on a surface of a substrate are disclosed. The methods may include: providing a substrate into a reaction chamber; and depositing a molybdenum nitride film directly on the surface of the substrate by performing one or more unit deposition cycles of cyclical deposition process, wherein a unit deposition cycle may include, contacting the substrate with a first vapor phase reactant comprising a molybdenum halide precursor, and contacting the substrate with a second vapor phase reactant comprising a nitrogen precursor. Semiconductor device structures including a molybdenum nitride film are also disclosed.

Abstract: Described herein is a process and system for constructing three-dimensional (3D) representations of roof structures. The system can create representations of roof structures of arbitrary complexity and can create representations of dependent roof structures such as dormers. The system can create representations of roof structures that conventional methods cannot create, such as roofs with edges that are not coplanar, roofs with faces that do not connect to exterior edges, roofs composed of sub-structures, or roofs with dependent structures such as dormers.