Patents by Inventor Christopher Toombs

Christopher Toombs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • END-TIDAL GAS MONITORING APPARATUS
    Publication number: 20150032019
    Abstract: A non-invasive monitoring apparatus for end-tidal gas concentrations, and a method of use thereof, is described for the detection of endogenous gas concentrations, including respiratory gases, in exhaled breath.
    Type: Application
    Filed: June 27, 2012
    Publication date: January 29, 2015
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Jaron Acker, David Christensen, John C. Falligant, Michael A. Insko, John Klaus, Federick J. Montgomery, Christopher Toombs
  • Methods of treating stroke
    Publication number: 20080095760
    Abstract: A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of ?2-macroglobulin in the circulating blood. A method is also provided for the treatment of a blood clot in, around or attached to an indwelling vascular access device. A method for restoring patency and function of an indwelling vascular access device is also provided.
    Type: Application
    Filed: November 13, 2007
    Publication date: April 24, 2008
    Applicant: Amgen Inc.
    Inventor: Christopher Toombs
  • METHODS OF INCREASING LEAN TISSUE MASS USING OB PROTEIN COMPOSITIONS
    Publication number: 20070224193
    Abstract: DNA sequences comprising nucleic acids encoding fusion proteins comprising an Fc portion of an antibody attached at the N-terminus of an OB protein moiety, vectors comprising such DNA sequences, host cells comprising such vectors or DNA sequences, and processes for preparing such fusion proteins, and pharmaceutical compositions comprising such fusion proteins, are described.
    Type: Application
    Filed: March 16, 2007
    Publication date: September 27, 2007
    Applicant: AMGEN, INC.
    Inventors: Mary Pelleymounter, Christopher Toombs, Michael Mann
  • OB fusion protein compositions and methods
    Publication number: 20070020284
    Abstract: The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or chemical fusion protein comprising the Fc immunoglobulin region, derivative or analog fused to the N-terminal portion of the OB protein, derivative or analog.
    Type: Application
    Filed: September 22, 2006
    Publication date: January 25, 2007
    Applicant: Amgen, Inc.
    Inventors: Michael Mann, Randy Hecht, Mary Pelleymounter, Christopher Toombs
  • Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
    Publication number: 20060035299
    Abstract: A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of ?2-macroglobulin in the circulating blood. A method is also provided for the treatment of a blood clot in, around or attached to an indwelling vascular access device. A method for restoring patency and function of an indwelling vascular access device is also provided.
    Type: Application
    Filed: October 13, 2005
    Publication date: February 16, 2006
    Applicant: Amgen Inc.
    Inventor: Christopher Toombs
  • Methods of treating peripheral arterial occlusions
    Publication number: 20060029592
    Abstract: A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of ?2-macroglobulin in the circulating blood. A method is also provided for the treatment of a blood clot in, around or attached to an indwelling vascular access device. A method for restoring patency and function of an indwelling vascular access device is also provided.
    Type: Application
    Filed: October 13, 2005
    Publication date: February 9, 2006
    Applicant: Amgen Inc.
    Inventor: Christopher Toombs
  • Methods of increasing lean tissue mass using OB protein compositions
    Publication number: 20050176107
    Abstract: The present invention provides methods of creating and using OB protein compositions with an antibody constant region or portion thereof fused to an OB protein. The fusion protein is created by attaching the polyamino acids to the OB protein moiety. The fusion proteins can then be used for various therapeutic uses.
    Type: Application
    Filed: January 11, 2005
    Publication date: August 11, 2005
    Inventors: Mary Pelleymounter, Christopher Toombs, Michael Mann
  • OB fusion protein compositions and methods
    Publication number: 20050163799
    Abstract: The present invention relates to Fc-OB fusion protein compositions, methods of preparation of such compositions and uses thereof. In particular, the present invention relates to a genetic or chemical fusion protein comprising the Fc immunoglobulin region, derivative or analog fused to the N-terminal portion of the OB protein, derivative or analog.
    Type: Application
    Filed: February 8, 2005
    Publication date: July 28, 2005
    Inventors: Michael Mann, Randy Hecht, Mary Pelleymounter, Christopher Toombs