Patents by Inventor Christopher W. Doecke

Christopher W. Doecke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED PICTET-SPENGLER REACTION AND PRODUCTS PREPARED THEREFROM
    Publication number: 20090312548
    Abstract: A method of introducing a second stereogenic center into a tetrahydro-?-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 17, 2009
    Inventors: Mark W. Orme, Michael J. Martinelli, Christopher W. Doecke, Joseph M. Pawlak, Erik C. Chelius
  • Modified Pictet-Spengler reaction and products prepared therefrom
    Patent number: 7550479
    Abstract: A method of introducing a second stereogenic center into a tetrahydro-?-carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: June 23, 2009
    Assignee: Lilly ICOS LLC
    Inventors: Mark W. Orme, Michael J. Martinelli, Christopher W. Doecke, Joseph M. Pawlak, Erik C. Chelius
  • Process of enantiomeric separation of carbacephem intermediates
    Patent number: 5142038
    Abstract: Enantiomerically pure .beta.-lactam intermediates of the formula (I) ##STR1## are isolated from a haloalkane solvent through precipitation with methyl-t-butyl ether or methanol. The products thus obtained are key intermediates in the synthesis of antibiotic aagents. The process is appropriate for large scale production.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: August 25, 1992
    Assignee: Eli Lilly and Company
    Inventors: Christopher W. Doecke, Jeffrey N. Levy, Wayne D. Luke, Michael A. Staszak