Abstract: The present disclosure provides methods for treating a subject having a HER2 non-amplified (HER2-negative) cancer or low HER2 expressing (HER2-low) cancer, comprising detecting expression of a BCAR4 gene fusion in a biological sample from the subject. If expression of the BCAR4 gene fusion is detected, a HER2-targeted cancer treatment is administered to the subject; if expression of the BCAR4 gene fusion is not detected, a cancer treatment that is not HER2-targeted is administered to the subject. Methods of predicting response to a HER2-targeted cancer treatment and detecting BCAR4 or BCAR4 gene fusion activation are also provided.

Abstract: A method of media content discovery and playback, the method including receiving a query for media content items from a search client, the query including one or more user subscriber group identifiers and a plurality of search criteria, filtering a plurality of available media content items according to the query to generate a list of matching content items among the plurality of available media content items, returning the list of matching content items to the search client, receiving from the search client a selection token with a content item to subscriber group mapping, providing the token to a user rights manager, receiving a signature authentication from the user rights manager, and issuing a playback key to the search client.

Abstract: Provided herein are systems, methods and computer readable media for proving gift giving within a group. Consumers may register for a gift giving program, create a group and invite other consumers to participate. Group members may be randomly assigned to a group, or assigned to a group based on an invitation or indicated group. Relationships between gift givers and recipients within a group may be determined, such as in a randomized format. Gift givers may purchase a gift, such as a good or a promotion from a promotion and marketing service. The promotion and marketing service may assign the promotion to the recipient so that the recipient may redeem the promotion for a good, service, or experience. Promotions may be automatically purchased on behalf of a gift giver who fails to purchase the promotion by a gift-giving deadline.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: The present disclosure relates to transcription cassettes comprising nucleic acids encoding RuvBL1 and/or RuvBL2 and the use of said vectors in gene therapy for the treatment of neurodegenerative diseases that result from expression of polymorphic repeat expansions of the GGGGCC (SEQ ID NO: 5) hexanucleotide-repeat sequence in the first intron of the C9ORF72 gene; pharmaceutical compositions comprising said vectors and including uses and methods to treat neurodegenerative diseases.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: Provided herein are systems, methods and computer readable media for proving gift giving within a group. Consumers may register for a gift giving program, create a group and invite other consumers to participate. Group members may be randomly assigned to a group, or assigned to a group based on an invitation or indicated group. Relationships between gift givers and recipients within a group may be determined, such as in a randomized format. Gift givers may purchase a gift, such as a good or a promotion from a promotion and marketing service. The promotion and marketing service may assign the promotion to the recipient so that the recipient may redeem the promotion for a good, service, or experience. Promotions may be automatically purchased on behalf of a gift giver who fails to purchase the promotion by a gift-giving deadline.

Abstract: Provided herein are systems, methods and computer readable media for proving gift giving within a group. Consumers may register for a gift giving program, create a group and invite other consumers to participate. Group members may be randomly assigned to a group, or assigned to a group based on an invitation or indicated group. Relationships between gift givers and recipients within a group may be determined, such as in a randomized format. Gift givers may purchase a gift, such as a good or a promotion from a promotion and marketing service. The promotion and marketing service may assign the promotion to the recipient so that the recipient may redeem the promotion for a good, service, or experience. Promotions may be automatically purchased on behalf of a gift giver who fails to purchase the promotion by a gift-giving deadline.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: Provided herein are systems, methods and computer readable media for proving gift giving within a group. Consumers may register for a gift giving program, create a group and invite other consumers to participate. Group members may be randomly assigned to a group, or assigned to a group based on an invitation or indicated group. Relationships between gift givers and recipients within a group may be determined, such as in a randomized format. Gift givers may purchase a gift, such as a good or a promotion from a promotion and marketing service. The promotion and marketing service may assign the promotion to the recipient so that the recipient may redeem the promotion for a good, service, or experience. Promotions may be automatically purchased on behalf of a gift giver who fails to purchase the promotion by a gift-giving deadline.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: Provided herein are systems, methods and computer readable media for proving gift giving within a group. Consumers may register for a gift giving program, create a group and invite other consumers to participate. Group members may be randomly assigned to a group, or assigned to a group based on an invitation or indicated group. Relationships between gift givers and recipients within a group may be determined, such as in a randomized format. Gift givers may purchase a gift, such as a good or a promotion from a promotion and marketing service. The promotion and marketing service may assign the promotion to the recipient so that the recipient may redeem the promotion for a good, service, or experience. Promotions may be automatically purchased on behalf of a gift giver who fails to purchase the promotion by a gift-giving deadline.

Abstract: A composite string such as a bowstring or cable used in archery bows and crossbows includes multiple types of strands or multiple types of materials in its strands. The different materials or strands have different properties such as stiffness, strength, abrasion resistance, or density. The string therefore has specialized properties such as different properties when subjected to different tensile loads or optimized durability. A serving material is also used to bind strands of material to the string for silencing, vibration dampening, improving durability, or providing additional rigidity to select portions of the string.

Abstract: Flexible string dampers can include resilient bodies configured to be inserted between strands of a bowstring or cable in archery equipment. The dampers can include openings or recesses in along their longitudinal or transverse axes to provide additional flexibility and vibration dampening. Accessories and inserts can be added to the bowstring by positioning them within the openings or recesses, and the accessories and inserts can be exchanged from the bowstring without removing the damper and without needing external equipment such as a bow press to reduce tension on the string or cable. A damper can also be used as a peep sight with a central opening configured to change in width in response to changes in tension in the strands holding it in place.

Abstract: A composite string such as a bowstring or cable used in archery bows and crossbows includes multiple types of strands or multiple types of materials in its strands. The different materials or strands have different properties such as stiffness, strength, abrasion resistance, or density. The string therefore has specialized properties such as different properties when subjected to different tensile loads or optimized durability. A serving material is also used to bind strands of material to the string for silencing, vibration dampening, improving durability, or providing additional rigidity to select portions of the string.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.