Patents by Inventor Chu-Lai Hsiao

Chu-Lai Hsiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
    Patent number: 7521199
    Abstract: The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: April 21, 2009
    Assignee: Wyeth
    Inventors: Douglas C. Harnish, Marshall S. Scicchitano, Sotirios K. Karathanasis, Chu-Lai Hsiao
  • Crystal structure of estrogen receptor-beta complex and uses thereof
    Publication number: 20080227960
    Abstract: This invention is directed to the crystal structure of Estrogen Receptor-? (ER-?) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-?, which may be useful as novel chemotherapeutic agents.
    Type: Application
    Filed: April 13, 2007
    Publication date: September 18, 2008
    Applicant: Genetics Institute, LLC.
    Inventors: William S. Somers, Zhang-Bao Xu, Tatos N. Akopian, Chu-Lai Hsiao, Rayomand Unwalla
  • Method using crystal structure of estrogen receptor-? complex
    Patent number: 7235367
    Abstract: This invention is directed to the crystal structure of Estrogen Receptor-? (ER-?) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-?, which may be useful as novel chemotherapeutic agents.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: June 26, 2007
    Assignee: Genetics Institute, LLC.
    Inventors: William S. Somers, Zhang-Bao Xu, Tatos N. Akopian, Chu-Lai Hsiao, Rayomand Unwalla
  • Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
    Publication number: 20060252154
    Abstract: The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity.
    Type: Application
    Filed: June 21, 2006
    Publication date: November 9, 2006
    Applicant: Wyeth
    Inventors: Douglas Harnish, Marshall Scicchitano, Sotirios Karathanasis, Chu-Lai Hsiao
  • Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
    Patent number: 7094559
    Abstract: The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: August 22, 2006
    Assignee: Wyeth
    Inventors: Douglas C. Harnish, Marshall S. Scicchitano, Sotirios K. Karathanasis, Chu-Lai Hsiao
  • Solution structure of IL-13 and uses thereof
    Publication number: 20030013851
    Abstract: The present invention relates to the three dimensional solution structure of interleukin-13 (IL-13), as well as the identification and characterization of various binding active sites of IL-13. Also provided for by the present invention are methods of utilizing the three dimensional structure for the design and selection of potent and selective agents that interact with IL-13.
    Type: Application
    Filed: May 16, 2002
    Publication date: January 16, 2003
    Inventors: Robert Powers, Michelle Catino, Chu-Lai Hsiao, Karl Malakian, Franklin J. Moy, James M. Wilhelm
  • Crystal structure of estrogen receptor-beta complex and uses thereof
    Publication number: 20020072587
    Abstract: This invention is directed to the crystal structure of Estrogen Receptor-&bgr; (ER-&bgr;) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-&bgr;, which may be useful as novel chemotherapeutic agents.
    Type: Application
    Filed: July 11, 2001
    Publication date: June 13, 2002
    Inventors: William S. Somers, Zhang-Bao Xu, Tatos N. Akopian, Chu-Lai Hsiao, Rayomand Unwalla
  • Production of rotavirus in yeast
    Patent number: 4853333
    Abstract: There is disclosed a DNA transfer vector capable of replication in either a yeast cell or a bacterial cell and having inserted therein a DNA segment coding for human WA rotavirus surface antigen VP7. The transfer vector carrying the foreign DNA is used to transform yeast cells in order to produce the surface antigen VP7 which is capable of eliciting in vivo production of neutralizing antibodies with respect to human WA rotavirus. The surface antigen VP7 so elaborated and its use in a pharmaceutical vaccine composition are also disclosed.
    Type: Grant
    Filed: July 26, 1985
    Date of Patent: August 1, 1989
    Assignee: American Home Products Corporation
    Inventors: Chu-lai Hsiao, Bruce B. Mason, Alan R. Davis