Abstract: Methods and systems for administering directed fluidics during a medical procedure for removing an object are disclosed. A method includes inserting first and second medical instruments into a treatment site, providing irrigation and aspiration of the treatment site through the first and second medical instruments, determining a characteristic of one of the irrigation and the aspiration, and selecting a characteristic of the other of the irrigation and aspiration based on the determined characteristic.

Abstract: Certain aspects relate to percutaneous sheaths for medical procedures as well as to related systems and methods. For example, a system for performing a percutaneous assisted medical procedure can include a percutaneous sheath. The percutaneous sheath can include a first conduit for providing aspiration into the kidney and a second conduit for passing a catheter into the kidney. The system can also include an aspiration catheter configured to be inserted into the kidney through the second conduit of the percutaneous sheath. A fluidics system can include an irrigation source comprising a pump and an aspiration source comprising a vacuum. The irrigation source can be connected to a fluid inlet of the percutaneous sheath that is connected to the first conduit. The aspiration source can be connected to the aspiration catheter.

Abstract: A coil spring includes an elongated body (10) formed by a plurality of continuous coils (21, 31), and the body (10) includes an upper section (20) and a lower section (30), wherein pitches (22) and coil angles (23) of the coils (21) in the upper section (20) are consistent to form an upright profile (24) for the upper section (20), and wherein pitches (32) and coil angles (33) of two or more coils (31) at a free end of the lower section (30) is differed from the pitches (22) and the coil angles (23) of the coils (21) in the upper section (20) to form a gradually curved profile (34) for the lower section (30).

Abstract: A tool that is either hand-guided, or machine-guided, for performing surface treatments, such as mopping, of overhead surfaces includes a head for carrying an agitator having a generally planar face that is applied against the overhead surface being treated in uses. A transmission transmits power from a drive motor to the agitator, and an interface on the head is provided for connection to a mounting device by which the head is oriented and guided.

Abstract: An aspiration catheter can include an elongate shaft and an instrument base coupled to the shaft and configured to control actuation of at least a distal portion of the shaft. The shaft can include a lumen configured to couple to an aspiration system to provide aspiration to a target site, such as to remove an object from a patient. The instrument base can be controlled robotically and/or manually to articulate at least the distal portion of the shaft.

Abstract: An aspiration catheter can include an elongate shaft and an instrument base coupled to the shaft and configured to control actuation of at least a distal portion of the shaft. The shaft can include a lumen configured to couple to an aspiration system to provide aspiration to a target site, such as to remove an object from a patient. At least a portion of the distal end portion of the shaft can include an inner diameter that is smaller than an inner diameter of the rest of shaft to prevent objects that are larger than a particular size from entering.

Abstract: The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.

Abstract: A computer-implemented method for training a natural language translation model. The computer-implemented method includes: processing one or more sets of electronic parallel documents to obtain a plurality of aligned parallel sentences; creating a first training set including a subset of the plurality of aligned parallel sentences; and training the natural language translation model in a first stage using the first training set. The computer-implemented method further includes: modifying the first training set based on translation errors detected after the first stage of training; creating a second training set based on the modified first training set and at least some of the plurality of aligned parallel sentences not in the first training set; and training the natural language translation model in a second stage using the second training set so as to improve translation performance of the natural language translation model.

Abstract: A computer-implemented method for managing operation of an application includes: authenticating a user of the application or a user device associated with a user of the application; and establishing a session with the application and enabling access to the application for the user if the user or the user device is authenticated. The method further includes determining, after the user or the user device is authenticated, whether the user or the user device is or remains present. The method further includes maintaining the session and the enabling of access to the application if it is determined that the user or the user device is or remains present; and terminating the session and disabling access to the application if it is determined that the user or the user device is absent for a predetermined duration.

Abstract: The technology described herein is directed to inducible and repressible polypeptides and polypeptide systems. In particular, described herein are split sequence-specific nucleases and split recombinases that are linked to drug-inducible or drug-repressible dimerization domains. In some embodiments, the polypeptides comprise sequestering domains and/or have their expression controlled by an inducible promoter. In multiple aspects described herein are polynucleotides, vectors, cells, and pharmaceutical compositions comprising said polypeptides or polypeptide systems. Also described herein are methods of using said polypeptide systems to modulate the expression of a target polypeptide or to treat a subject in need of a cell therapy.

Abstract: A tool that is either hand-guided, or machine-guided, for performing surface treatments, such as mopping, of overhead surfaces includes a head for carrying an agitator having a generally planar face that is applied against the overhead surface being treated in uses. A transmission transmits power from a drive motor to the agitator, and an interface on the head is provided for connection to a mounting device by which the head is oriented and guided.

Abstract: Certain aspects relate to systems and techniques for an endoscopic system to access, visualize, and treat pathologies in various organs via natural orifices and lumens of various organs. In one aspect, the system includes an elongate shaft configured for insertion into a urinary tract of a patient. The elongate shaft can include a proximal section, a distal section, a tip portion, and a plurality of pull wires extending along the elongate shaft and terminating at the tip portion of the elongate shaft. The plurality of pull wires may include a first and second pull wire. The first pull wire may be configured to articulate each of the proximal section and the distal section in a first direction. The second pull wire may be configured to articulate the distal section in a second direction independently of the proximal section, the second direction being transverse to the first direction.

Abstract: The present invention provides for a fungus, especially in the form of fungal mycelium, that has altered glycogen synthase kinase-3 (GSK-3) expression and/or activity level and therefore exhibits modified characteristics in fruiting body development. Also provided are compositions and methods for generating living fungal mycelium with altered fruiting body development.

Abstract: The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.

Abstract: The present disclosure relates to therapeutic agents and combinations thereof (e.g., pharmaceutical compositions) for the treatment of a viral infection in a subject, tissue or cell.

Abstract: The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.

Abstract: The technology described herein is directed to inducible and repressible polypeptides and polypeptide systems. In particular, described herein are split sequence-specific nucleases and split recombinases that are linked to drug-inducible or drug-repressible dimerization domains. In some embodiments, the polypeptides comprise sequestering domains and/or have their expression controlled by an inducible promoter. In multiple aspects described herein are polynucleotides, vectors, cells, and pharmaceutical compositions comprising said polypeptides or polypeptide systems. Also described herein are methods of using said polypeptide systems to modulate the expression of a target polypeptide or to treat a subject in need of a cell therapy.

Abstract: A coil spring includes an elongated body (10) formed by a plurality of continuous coils (21, 31), and the body (10) includes an upper section (20) and a lower section (30), wherein pitches (22) and coil angles (23) of the coils (21) in the upper section (20) are generally consistent to form an upright profile (24) for the upper section (20), and wherein pitches (32) and coil angles (33) of two or more coils (31) at a free end of the lower section (30) is differed from the pitches (22) and the coil angles (23) of the coils (21) in the upper section (20) to form a gradually curved profile (34) for the lower section (30).

Abstract: The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.

Abstract: The disclosed embodiments include computer-implemented systems and methods that dynamically predict future occurrences of events using adaptively trained machine-learning or artificial-intelligence processes. For example, an apparatus may generate an input dataset based on elements of interaction data associated with an extraction interval. Based on an application of a trained artificial intelligence process to the input dataset, the apparatus may generate output data representative of a predicted likelihood of an occurrence of a first event during a first portion of a target interval, which may be separated from the extraction interval by a second portion of the target interval. The first event may be associated with a predetermined temporal duration within the first portion of the target interval. The apparatus may transmit a portion of the generated output data to a computing system, and the computing system may be configured to perform operations based on the portion of the output data.