Patents by Inventor Chung-Hwan Chen
Chung-Hwan Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11111184Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.Type: GrantFiled: December 2, 2016Date of Patent: September 7, 2021Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Chih-Kuang Wang, Mei-Ling Ho, Li-Cheng Pan, Yin-Chih Fu, Chung-Hwan Chen, Je-Ken Chang
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Publication number: 20210162074Abstract: The present invention relates to a method for treating or alleviating an osteoporosis in a subject. The method comprises steps of identifying the subject having the osteoporosis, and administering to the subject an effective amount of a composition that increases a level of Discoidin Domain Receptor 1 (DDR1) protein in the subject.Type: ApplicationFiled: February 5, 2021Publication date: June 3, 2021Applicant: Kaohsiung Medical UniversityInventors: Chau-Zen Wang, Chung-Hwan Chen, Liang-Yin Chou, Yu Chou, Mei-Ling Ho, Yi-Hsiung Lin
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Patent number: 10946021Abstract: The present invention relates to a use of Discoidin Domain Receptor 1 (DDR1) inhibitor in preparing a medicament for preventing or treating a joint disease. The present invention further relates to a use of DDR1 activator in preparing a medicament for preventing or treating abnormalities of endochondral ossification-related conditions.Type: GrantFiled: March 23, 2018Date of Patent: March 16, 2021Assignee: KAOHSIUNG MEDICAL UNIVERSITYInventors: Chau-Zen Wang, Chung-Hwan Chen, Liang-Yin Chou, Yu Chou, Mei-Ling Ho, Yi-Hsiung Lin
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Publication number: 20210015967Abstract: A method for preparing hyaluronic acid hydrogel microparticles and a use thereof in repairing articular cartilage defects, the method for preparing hyaluronic acid hydrogel microparticles includes: (a) reacting hyaluronic acid with methacrylic anhydride to synthesize a methacrylated hyaluronic acid conjugate; (b) mixing the methacrylated hyaluronic acid conjugate with a photoinitiator, and irradiating ultraviolet light to carry out a photopolymerization reaction so as to obtain a hyaluronic acid hydrogel; and (c) passing the hyaluronic acid hydrogel through a sieve to obtain hyaluronic acid hydrogel microparticles.Type: ApplicationFiled: March 23, 2018Publication date: January 21, 2021Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Mei-Ling HO, Je-Ken CHANG, Chung-Hwan CHEN, Hui-Ting CHEN, Shun Cheng WU, Benjamin TEONG
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Patent number: 10570365Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.Type: GrantFiled: December 21, 2017Date of Patent: February 25, 2020Assignee: Kaohsiung Medical UniversityInventors: Che-Hsin Lin, Yao-Hsien Wang, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho
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Publication number: 20200030332Abstract: The present invention relates to a use of Discoidin Domain Receptor 1 (DDR1) inhibitor in preparing a medicament for preventing or treating a joint disease. The present invention further relates to a use of DDR1 activator in preparing a medicament for preventing or treating abnormalities of endochondral ossification-related conditions.Type: ApplicationFiled: March 23, 2018Publication date: January 30, 2020Applicant: Kaohsiung Medical UniversityInventors: Chau-Zen Wang, Chung-Hwan Chen, Liang-Yin Chou, Yu Chou, Mei-Ling Ho, Yi-Hsiung Lin
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Publication number: 20200033232Abstract: Provided is a device for rapidly isolating cells from tissue, comprising: a stirring and cutting member, having a rotary cutting tool, wherein same is driven by a motor so as to rotate to stir and cut tissue, and can inject digestive enzymes to accelerate decomposition of the tissue; and double-layered nested cups comprising an inner cup and an outer cup, used for accommodating and filtering solution of required cells, wherein a filter device of the inner cup screens out the required cells, and the outer cup collects the filtered solution.Type: ApplicationFiled: September 29, 2016Publication date: January 30, 2020Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Che-Hsin Lin, Yao-Hsien Wang, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho
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Publication number: 20180354860Abstract: The present invention provides a method of additive manufacturing a 3D-printed article, comprising: (a) printing and depositing one or more layers of a slurry by using a 3D printer, wherein the slurry comprises a ceramic powder composition; (b) further injecting an oil around the one or more layers of slurry, wherein the height of the injected oil is lower than the height of the slurry; (c) repeating steps (a) and (b) until a main body with desired geometric shape is obtained; and (d) sintering the main body by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.Type: ApplicationFiled: December 2, 2016Publication date: December 13, 2018Inventors: Chih-Kuang Wang, Mei-Ling Ho, Li-Cheng Pan, Yin-Chih Fu, Chung-Hwan Chen, Je-Ken Chang
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Publication number: 20180328824Abstract: An automatic cell isolation and collection system for sorting out target cells from a sample includes a crush module, a centrifuge module, a transport module, and a control unit. The centrifuge module includes centrifuge tubes and a magnetic mechanism providing a magnetically attractive force to at least one of the centrifuge tubes. The control unit electrically communicates with the crush module, the centrifuge module, and the transport module, and controls operation of the crush module, transport of the sample via the transport module after the sample is crushed by the crush module, centrifugation of the centrifuge module, and operation of the magnetic mechanism for providing the magnetically attractive force.Type: ApplicationFiled: December 21, 2017Publication date: November 15, 2018Applicant: Kaohsiung Medical UniversityInventors: Che-Hsin Lin, Yao-Hsien Wang, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho
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Publication number: 20180298342Abstract: The present invention provides a composition for isolating adipose-derived stromal cells, which comprises a Type I collagenase of 0.5-8% (v/v); a Trypsin of 0.1-0.6% (v/v); and a metal ion chelating agent of 0.01-0.2% (v/v). The present invention further provides a method for isolating adipose-derived stromal cells, which method comprises obtaining an adipose tissue; treating the adipose tissue with the composition of the present invention; centrifuging the adipose tissue; and isolating the adipose tissue to obtain the adipose-derived stromal cells. The present invention facilitates rapid isolation of mesenchymal stromal cells within a short period of time in operating rooms and can be applied to regenerative medicine in the future.Type: ApplicationFiled: October 8, 2015Publication date: October 18, 2018Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: YAO-HSIEN WANG, CHUNG-HWAN CHEN, MEI-LING HO, JE-KEN CHANG
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Publication number: 20150329592Abstract: The present invention relates to a gold fluorescence resonance energy transfer nanoprobe comprising a gold fluorescence donor, a gold fluorescence acceptor, and a linker fragment that connects the gold fluorescence donor and the gold fluorescence acceptor, wherein the fluorescence resonance energy transfer is carried out between the gold fluorescence donor and the gold fluorescence acceptor. This all gold probe employing fluorescence resonance energy transfer technique can be used for detecting diseases such as arthritis, osteoporosis, and cancer metastasis.Type: ApplicationFiled: May 11, 2015Publication date: November 19, 2015Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Chih-Kuang Wang, Mei-Ling Ho, Chung-Hwan Chen, Yin-Chih Fu, Jia-Huie Lin, Chih-Yun Lee, Je-Ken Chang
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Patent number: 8586533Abstract: A method for treating early-stage osteoarthritis in an animal is provided. The method comprises delivery of a therapeutically effective amount of a parathyroid hormone (PTH) or a PTH derived substance to an affected joint cavity of the patient. Methods for inhibiting articular chondrocytes apoptosis and for inhibiting a degenerative process of articular chondrocytes in an afflicted animal are also provided.Type: GrantFiled: December 15, 2009Date of Patent: November 19, 2013Assignee: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Chung-Hwan Chen
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Patent number: 8530420Abstract: A method for treating and/or inhibiting arthritis is provided. The method includes administering an effective amount of a composition including a parathyroid hormone and a pharmaceutically acceptable carrier or salt to a subject with arthritis. Additionally, a method for inhibiting and/or rescuing terminal differentiation of cells is also provided.Type: GrantFiled: December 16, 2008Date of Patent: September 10, 2013Assignee: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Chung-Hwan Chen
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Publication number: 20100160229Abstract: A method for treating early-stage osteoarthritis in an animal is provided. The method comprises delivery of a therapeutically effective amount of a parathyroid hormone (PTH) or a PTH derived substance to an affected joint cavity of the patient. Methods for inhibiting articular chondrocytes apoptosis and for inhibiting a degenerative process of articular chondrocytes in an afflicted animal are also provided.Type: ApplicationFiled: December 15, 2009Publication date: June 24, 2010Applicant: Kaohsiung Medical UniversityInventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang, Yin-Chih Fu, Chung-Hwan Chen
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Publication number: 20100150997Abstract: A method for treating and/or inhibiting arthritis is provided. The method includes administering an effective amount of a composition including a parathyroid hormone and a pharmaceutically acceptable carrier or salt to a subject with arthritis. Additionally, a method for inhibiting and/or rescuing terminal differentiation of cells is also provided.Type: ApplicationFiled: December 16, 2008Publication date: June 17, 2010Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Mei-Ling HO, Gwo-Jaw WANG, Je-Ken CHANG, Yin-Chih FU, Chung-Hwan CHEN
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Publication number: 20090170200Abstract: A medium for culturing stem cell. The stem cell medium of the invention comprises a fetal bovine serum, one or plurality of amino acid, one or plurality of vitamin, one or plurality of growth factor, one or plurality of inorganic salt, one or plurality of antioxidant, wherein the stem cell medium has a calcium concentration of less than about 1.8 mM, and the fetal bovine serum is present in an amount of less than about 10% by volume of the medium. The stem cell medium of the invention can maintain the proliferative and self-renewal capacity of the stem cells and keep stem cells at a steady stage.Type: ApplicationFiled: April 21, 2008Publication date: July 2, 2009Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Ching-Hua Yeh, Gwo-Jaw Wang, Mei-Ling Ho, Je-Ken Chang, Chung-Hwan Chen