Abstract: A microelectromechanical system (MEMS) structure and method of forming the MEMS device, including forming a first metallization structure over a complementary metal-oxide-semiconductor (CMOS) wafer, where the first metallization structure includes a first sacrificial oxide layer and a first metal contact pad. A second metallization structure is formed over a MEMS wafer, where the second metallization structure includes a second sacrificial oxide layer and a second metal contact pad. The first metallization structure and second metallization structure are then bonded together. After the first metallization structure and second metallization structure are bonded together, patterning and etching the MEMS wafer to form a MEMS element over the second sacrificial oxide layer. After the MEMS element is formed, removing the first sacrificial oxide layer and second sacrificial oxide layer to allow the MEMS element to move freely about an axis.

Abstract: Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.

Abstract: Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.

Abstract: This invention presents a fast and effective method to detect macromolecules such as peptides. Using a multifunctional chiral monomer, it combines molecular imprinting polymerization technology with a quartz crystal microbalance for detection of peptides to the ng/ml scale.

Abstract: Based on the direct formation of molecularly imprinted polymer on gold electrode, the present invention provides a peptide sensor for the detection of low-molecular-weight peptides. A new cross-linking monomer, (N-Acr-L-Cys-NHBn)2 is employed to attach the surface of the chip and to copolymerize with other monomers. Interestingly, N-benzylacrylamide participating both polymerization and recognition is carried out in an aqueous environment. Using quartz crystal microbalance detection, short peptides can be monitored by their interaction with plastic antibodies specific for the target peptides. The selectivity of molecularly imprinted polymer and the sensitivity of such artificial biosensors have collaborated to differentiate traces of oxytocin and vasopressin to the ng/ml scale.