Patents by Inventor Chunhui Xie

Chunhui Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11992506
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Grant
    Filed: November 1, 2022
    Date of Patent: May 28, 2024
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
  • Publication number: 20230395250
    Abstract: Systems for customizing and troubleshooting the display of surgical data and wireless pairing techniques for surgical instruments are disclosed.
    Type: Application
    Filed: May 16, 2023
    Publication date: December 7, 2023
    Inventors: Christopher A. Denzinger, Monica L. Z. Rivard, Matthew D. Cowperthwait, Felix J. Bork, Risto Kojcev, Leonardo N. Rossoni, Chunhui Xie
  • Publication number: 20230381361
    Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.
    Type: Application
    Filed: August 14, 2023
    Publication date: November 30, 2023
    Applicant: ASP Global Manufacturing GMBH
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
  • Publication number: 20230364291
    Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.
    Type: Application
    Filed: May 12, 2023
    Publication date: November 16, 2023
    Applicant: ASP Global Manufacturing GMBH
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
  • Publication number: 20230358630
    Abstract: A boundary adaptive structural fatigue damage detection method driven by time-domain information entropy comprises a sensor sequence composed of several sensors arranged on the structure, which is used to apply excitation to the structure, collect the displacement time-history response curves at different positions on the structure, and establish a database of time-history data. According to the data set in the database, the information entropy of the time-history response at different positions on the acquisition structure is obtained based on the information entropy to measure the disorder degree of the time-domain response signal. According to the location of several sensors, the information entropy values of the time-history response are connected in turn to obtain the time-history information entropy curve of the whole structure. Analyze of time-history information entropy curve, and the information entropy curve will show jump phenomena to determine the location of the crack.
    Type: Application
    Filed: April 13, 2023
    Publication date: November 9, 2023
    Applicants: Jiangxi University of Science and Technology, Hohai University, JSTI Group
    Inventors: Maosen CAO, Tongfa DENG, Ruke TAN, Chunhui XIE, Yufeng ZHANG, Zha NI, Zeyu WANG
  • Patent number: 11766495
    Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: September 26, 2023
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
  • Publication number: 20230218676
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: November 1, 2022
    Publication date: July 13, 2023
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhui Xie, Bryce W. Carey, Aleksander Szymaniak, Christopher Thanos, Evrett Thompson, Rebecca Chinn, Suyash Raj
  • Patent number: 11660365
    Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: May 30, 2023
    Assignee: ASP Global Manufacturing GmbH
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
  • Publication number: 20230092449
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: November 16, 2022
    Publication date: March 23, 2023
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhui Xie
  • Publication number: 20220090020
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: July 30, 2021
    Publication date: March 24, 2022
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: George Harb, Chunhui Xie
  • Publication number: 20200330636
    Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.
    Type: Application
    Filed: May 7, 2020
    Publication date: October 22, 2020
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
  • Publication number: 20200179549
    Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.
    Type: Application
    Filed: February 10, 2020
    Publication date: June 11, 2020
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
  • Patent number: 10668180
    Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: June 2, 2020
    Assignee: ASP GLOBAL MANUFACTURING GMBH
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer
  • Patent number: 10561753
    Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: February 18, 2020
    Assignee: ASP GLOBAL MANUFACTURING GMBH
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
  • Patent number: 10356949
    Abstract: A server heat dissipation system is provided, comprising a liquid cooling server cabinet comprising a cabinet body and multiple liquid cooling servers provided inside the cabinet body, wherein it is provided with a liquid cooling device to perform direct liquid cooling to the liquid cooling servers, and with an auxiliary heat dissipation device to perform auxiliary heat dissipation to the liquid cooling servers. The present invention provides high density cooling, high heat exchange efficiency, no local overheating, small space occupied, high reliability, low noise, and long life.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: July 16, 2019
    Assignee: GUANGDONG SHENLING ENVIRONMENTAL SYSTEMS CO., LTD.
    Inventors: Zhanhua Pan, Minhua Li, Hua Chen, Chunhui Xie, Ti Ouyang, Xuewei Zhang, Yuqun Qiu
  • Publication number: 20180042140
    Abstract: A server heat dissipation system is provided, comprising a liquid cooling server cabinet comprising a cabinet body and multiple liquid cooling servers provided inside the cabinet body, wherein it is provided with a liquid cooling device to perform direct liquid cooling to the liquid cooling servers, and with an auxiliary heat dissipation device to perform auxiliary heat dissipation to the liquid cooling servers. The present invention provides high density cooling, high heat exchange efficiency, no local overheating, small space occupied, high reliability, low noise, and long life.
    Type: Application
    Filed: May 5, 2015
    Publication date: February 8, 2018
    Inventors: Zhanhua PAN, Minhua LI, Hua CHEN, Chunhui XIE, Ti OUYANG, Xuewei ZHANG, Yuqun QIU
  • Publication number: 20170252474
    Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.
    Type: Application
    Filed: February 24, 2017
    Publication date: September 7, 2017
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
  • Publication number: 20170252473
    Abstract: A sterilizing cabinet performs a method of processing a medical device, such as a used medical device or an otherwise non-sterile medical device. The method includes receiving input from a user selecting a sterilization cycle from a plurality of available sterilization cycles. The sterilizing cabinet identifies a biological indicator associated with the selected sterilization cycle. The sterilizing cabinet prompts the user via a touch screen display to place the medical device and the biological indicator into a sterilization chamber of a sterilizing cabinet. The sterilizing cabinet performs load conditioning on the medical device in the sterilization chamber. The sterilizing cabinet then performs the selected sterilization cycle on the medical device in the sterilization chamber after completing the act of load conditioning.
    Type: Application
    Filed: February 24, 2017
    Publication date: September 7, 2017
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood