Patents by Inventor Chunrong Ma

Chunrong Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID STATE FORMS OF FUSED HETEROAROMATIC PYRROLIDINONES
    Publication number: 20230348461
    Abstract: Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((1R,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.
    Type: Application
    Filed: December 23, 2022
    Publication date: November 2, 2023
    Inventors: Rongliang Chen, Tomonori Ichibakase, Chunrong Ma, Christopher F. Matthews, Hajime Motoyoshi, Colin O’Bryan, Kentaro Yaji, Naoki Yoshikawa
  • Solid state forms of fused heteroaromatic pyrrolidinones
    Patent number: 11352355
    Abstract: Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((1R,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: June 7, 2022
    Assignee: Calithera Biosciences, Inc.
    Inventors: Rongliang Chen, Tomonori Ichibakase, Chunrong Ma, Christopher F. Matthews, Hajime Motoyoshi, Colin O'Bryan, Kentaro Yaji, Naoki Yoshikawa
  • SOLID STATE FORMS OF FUSED HETEROAROMATIC PYRROLIDINONES
    Publication number: 20200339573
    Abstract: Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((1R,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.
    Type: Application
    Filed: May 8, 2020
    Publication date: October 29, 2020
    Inventors: Rongliang Chen, Tomonori Ichibakase, Chunrong Ma, Christopher F. Matthews, Hajime Motoyoshi, Colin O'Bryan, Kentaro Yaji, Naoki Yoshikawa
  • Solid state forms of fused heteroaromatic pyrrolidinones
    Patent number: 10676473
    Abstract: Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((1R,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: June 9, 2020
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Rongliang Chen, Tomonori Ichibakase, Chunrong Ma, Christopher F. Matthews, Hajime Motoyoshi, Colin O'Bryan, Kentaro Yaji, Naoki Yoshikawa
  • Solid State Forms of Fused Heteroaromatic Pyrrolidinones
    Publication number: 20160176869
    Abstract: Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((1R,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.
    Type: Application
    Filed: December 17, 2015
    Publication date: June 23, 2016
    Inventors: Rongliang Chen, Tomonori ICHIBAKASE, Chunrong MA, Christopher MATTHEWS, Hajime MOTOYOSHI, Colin O'BRYAN, Kentaro YAJI, Naoki YOSHIKAWA
  • Method of preparing poly(ADP-ribose) polymerases inhibitors
    Patent number: 7323562
    Abstract: This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: January 29, 2008
    Assignees: Agouron Pharmaceuticals, Inc., Cancer Research Technology Ltd.
    Inventors: Chunrong Ma, Naresh Nayyar, Nebojsa Slobodan Stanković
  • Synthesis of 5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester
    Publication number: 20060116519
    Abstract: The present invention relates to novel synthetic methods for the preparation of intermediates of 3{5-[3-(4,6-Difluoro-1H-benzoimidazol-2-yl)-1H-indazol-5-yl]4-methyl-pyridin-3-yl methyl}-ethyl-amine.
    Type: Application
    Filed: September 28, 2005
    Publication date: June 1, 2006
    Inventors: Chunrong Ma, Qingping Tian
  • Method of preparing poly(ADP-ribose) polymerases inhibitors
    Publication number: 20060063926
    Abstract: This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.
    Type: Application
    Filed: September 21, 2005
    Publication date: March 23, 2006
    Inventors: Chunrong Ma, Naresh Nayyar, Nebojsa Stankovic
  • Methods for reducing alcohol cravings in chronic alcoholics
    Publication number: 20030176456
    Abstract: Methods are provided to reduce the anxiety associated with alcohol withdrawal in chronic alcoholics.
    Type: Application
    Filed: December 23, 2002
    Publication date: September 18, 2003
    Inventors: Harry L. June, James M. Cook, Chunrong Ma