Abstract: The invention relates to (i) an angiogenesis gene signature and (ii) a monocytic myeloid-derived suppressor cell (mMDSC) gene signature that are each predictive of patient response to treatment with a PD-1 antagonist, wherein the angiogenesis signature comprises five or more genes. More specifically, a lower angiogenesis score is associated with favorable response to a PD-1 antagonist in a patient with cancer. Similarly, a lower mMDSC score is associated with favorable response to a PD-1 antagonist in a patient with cancer. Also provided are methods of treating a cancer patient with a PD-1 antagonist that were identified as either (i) positive for the angiogenesis gene signature biomarker of the invention or (ii) positive for the mMDSC gene signature biomarker of the invention.

Abstract: The invention relates to a stromal/EMT/TGF? signature that is predictive of patient response to treatment with a PD-1 antagonist, wherein the stromal/EMT/TGF? signature comprises five or more genes selected from Table 1 disclosed herein. More specifically, a lower stromal/EMT/TGF-? score is associated with favorable response to a PD-1 antagonist in a patient with cancer. Also provided are methods of treating a cancer patient with a PD-1 antagonist that were identified as positive for the stromal/EMT/TGF? biomarker of the invention. The disclosure also provides methods and kits for testing tumor samples for the biomarkers.

Abstract: The present invention relates to a method and an apparatus for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt, which are applicable in geotechnical engineering. The method provided by the invention is for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt; the method is convenient to operate, non-destructive to an anchor bolt, and capable of testing an anchorage length of the anchor bolt. The present invention further provides an apparatus for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt. The apparatus has a simple structure, is convenient to install, and is capable of measuring an anchorage length of an anchor bolt without damaging the anchor bolt.

Abstract: Disclosed is a combined structure of a fishing net cage and floating wind turbine foundation. The combined structure includes a wind turbine and a polygonal deep-sea fishing net cage floating body. The polygonal deep-sea fishing net cage floating body comprises an upper polygonal floating body frame, a bottom ring beam, and a middle truss structure, and a connecting column disposed between the upper polygonal floating body frame and the bottom ring beam. A connection structure of the wind turbine set is disposed on the upper polygonal floating body frame. The bottom of the polygonal deep-sea fishing cage floating body is provided with an interface connected with a steel cable of a mooring system. A sub-tank capable of providing ballast by loading water and buoyancy is disposed in the polygonal deep-sea fishing net cage floating body.

Abstract: The present invention provides a yieldable construction method for early releasing surrounding rock deformation on a weak toppling slope, thereby reducing surrounding rock toppling deformation risk in and after an excavation process and ensuring overall slope stability and safety of a supporting structure. A technical solution of the present invention is as follows: loosing a rock mass through controlled blasting; inducing toppling deformation of the slope by injecting water and softening a blasting relaxation part of the rock mass; determining timing of water injection by monitoring slope surface displacement characteristics of the slope; and performing a normal excavation process of the toppling deformation slope after injecting is completed. The present invention is applicable to design and construction of high slope engineering of a special kind of rocks, i.e., a toppling deformation slope composed of weak rock masses.

Abstract: The present invention relates to a method and an apparatus for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt, which are applicable in geotechnical engineering. The method provided by the invention is for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt; the method is convenient to operate, non-destructive to an anchor bolt, and capable of testing an anchorage length of the anchor bolt. The present invention further provides an apparatus for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt. The apparatus has a simple structure, is convenient to install, and is capable of measuring an anchorage length of an anchor bolt without damaging the anchor bolt.

Abstract: The present invention relates to a surrounding rock pretreatment method for a TBM (tunnel boring machine) passing through a round tunnel section with high rock-burst risk. A technical solution of the present invention is as follows: the surrounding rock pretreatment method includes the following steps: 1. determining a pretreatment area, wherein an area in which a clear spacing between a to-be-constructed tunnel and an adjacent existing tunnel in a TBM tunneling direction is less than 2 times that of a tunnel diameter of the TBM to-be-constructed tunnel is the pretreatment area: 2. performing controlled blasting; 3. injecting high pressure water, and selecting part of blast holes I to perform cyclic water injection pressurizing; and 4, performing normal tunneling by the TBM.

Abstract: The present invention relates to a surrounding rock pretreatment method for a TBM (tunnel boring machine) passing through a round tunnel section with high rock-burst risk. A technical solution of the present invention is as follows: the surrounding rock pretreatment method includes the following steps: 1. determining a pretreatment area, wherein an area in which a clear spacing between a to-be-constructed tunnel and an adjacent existing tunnel in a TBM tunneling direction is less than 2 times that of a tunnel diameter of the TBM to-be-constructed tunnel is the pretreatment area: 2. performing controlled blasting; 3. injecting high pressure water, and selecting part of blast holes I to perform cyclic water injection pressurizing; and 4, performing normal tunneling by the TBM.

Abstract: The present invention provides a yieldable construction method for early releasing surrounding rock deformation on a weak toppling slope, thereby reducing surrounding rock toppling deformation risk in and after an excavation process and ensuring overall slope stability and safety of a supporting structure. A technical solution of the present invention is as follows: loosing a rock mass through controlled blasting; inducing toppling deformation of the slope by injecting water and softening a blasting relaxation part of the rock mass; determining timing of water injection by monitoring slope surface displacement characteristics of the slope; and performing a normal excavation process of the toppling deformation slope after injecting is completed. The present invention is applicable to design and construction of high slope engineering of a special kind of rocks, i.e., a toppling deformation slope composed of weak rock masses.

Abstract: The present invention relates to a method and an apparatus for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt, which are applicable in geotechnical engineering. The method provided by the invention is for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt; the method is convenient to operate, non-destructive to an anchor bolt, and capable of testing an anchorage length of the anchor bolt. The present invention further provides an apparatus for non-destructive testing of an effective anchorage depth of a fully grouted anchor bolt. The apparatus has a simple structure, is convenient to install, and is capable of measuring an anchorage length of an anchor bolt without damaging the anchor bolt.

Abstract: The present disclosure relates to a method for sampling rock mass, especially jointed rock mass. The present disclosure provides a simple and convenient method for sampling jointed rock mass to prevent the rock sample from being disturbed and damaged during sampling and accordingly resulting in opening of the weak structural planes, to therefore obtain rock specimen correctly reflecting the basic physical and mechanical characteristics of rock mass comprising integral fissure network. The method for sampling jointed rock mass of the present disclosure comprises the following steps: Step a: Siting; Step b: Drilling; Step c: Protecting; and Step d: Sampling. The method is suitable for determining the basic mechanical properties of the rock mass and for assessing the stability of caverns in jointed rock mass.

Abstract: Provided are a method, system, and computer-readable medium for determining whether a copy number variation exists in a sample genome. The method includes sequencing a sample genome to obtain a sequencing result formed by multiple reads; comparing the sequencing result with a reference genome sequence to determine the distribution of the reads on the reference genome sequence; determining, based on the distribution of the reads on the reference genome sequence, multiple breakpoints on the reference genome sequence, wherein the number of the reads on either side of each breakpoint are significantly different; determining, based on the plurality of breakpoints, a detection window on the reference genome; determining, based on the reads falling in the detection window, a parameter; and determining, based on the difference between the first parameter and a preset threshold, whether a copy number variation exists in the sample genome against the detection window.

Abstract: The present disclosure relates to a method for sampling rock mass, especially jointed rock mass. The present disclosure provides a simple and convenient method for sampling jointed rock mass to prevent the rock sample from being disturbed and damaged during sampling and accordingly resulting in opening of the weak structural planes, to therefore obtain rock specimen correctly reflecting the basic physical and mechanical characteristics of rock mass comprising integral fissure network. The method for sampling jointed rock mass of the present disclosure comprises the following steps: Step a: Siting; Step b: Drilling; Step c: Protecting; and Step d: Sampling. The method is suitable for determining the basic mechanical properties of the rock mass and for assessing the stability of caverns in jointed rock mass.

Abstract: The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species. Reproductive-preferred promoters, regulatory elements, and cytotoxic nucleotide sequences are disclosed herein, as are constructs and methods for genetic ablation.

Abstract: The present disclosure relates to a new, distinct and stable variety of freeze-tolerant Eucalyptus hybrid variety. Following exposure to cold temperature, and compared to its parent plant, the freeze-tolerant hybrid variety displays increased height, less leaf damage, less dieback of main stem, less crown defoliation, and improved tree stem form.

Abstract: The present disclosure relates to freeze-tolerant transgenic Eucalyptus, including methodology for making and products produced there from. Following exposure to cold temperature, and compared to a control plant, the freeze-tolerant Eucalyptus displays a freeze-tolerant phenotype characterized by at least one of increased height, less leaf damage, less dieback of main stem, less crown defoliation, and/or improved tree stem form.

Abstract: The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species. Reproductive-preferred promoters, regulatory elements, and cytotoxic nucleotide sequences are disclosed herein, as are constructs and methods for genetic ablation.

Abstract: The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species. Reproductive-preferred promoters, regulatory elements, and cytotoxic nucleotide sequences are disclosed herein, as are constructs and methods for genetic ablation.

Abstract: The invention provides molecular markers that are associated with responsiveness of a cancer patient to a chemotherapy treatment, and methods and computer systems for determining such responsiveness based on measurements of these molecular markers. The present invention also provides methods and compositions for enhancing the efficacy of chemotherapies in patients by modulating the expression or activity of genes encoding these molecular markers and/or their encoded proteins.