Abstract: A monitoring system operable to monitor an oilfield additive system having multiple components. The oilfield additive system is operable to transfer an additive-containing substance for injection into a wellbore. The monitoring system includes sensors each associated with, and operable to generate information related to an operational parameter of, a corresponding one of the oilfield additive system components. The monitoring system also includes a monitoring device in communication with the sensors and operable to record the information generated by the sensors to generate a database. The database includes information indicative of maintenance aspects of the oilfield additive system and/or the oilfield additive system components.

Abstract: The present invention relates to a method for estimating the effectiveness of treatment with an anti-CD20 agent in a patient with rheumatoid arthritis and who has had an inadequate response to at least one prior biotherapy, consisting in analysing a biological sample of said patient for the expression of a set of biomarkers, the results of which make it possible to determine whether said agent is a treatment that will engender a beneficial response for said patient. The present invention also relates to a system for estimating the effectiveness of said treatment in said patient comprising means for measuring or receiving data, the expression level of said biomarkers and means for processing these data configured to estimate said effectiveness of said treatment in said patient.

Abstract: The present invention relates to a method for estimating the effectiveness of treatment with an anti-TNF? agent in a patient with rheumatoid arthritis and who has had an inadequate response to at least one prior biotherapy, consisting in analysing a biological sample of said patient for the expression of a set of biomarkers, the results of which make it possible to determine whether said agent is a treatment that will engender a beneficial response for said patient. The present invention also relates to a system for estimating the effectiveness of said treatment in said patient comprising means for measuring or receiving data, the expression level of said biomarkers and means for processing these data configured to estimate said effectiveness of the treatment in said patient.

Abstract: A graft copolymer and a method of delivering an active agent to a subject are provided. The graft copolymer includes a polymer backbone, a hydrophilic segment grafted to the polymer backbone, a pH-responsive segment grafted to the polymer backbone, and an endosomal disruption segment grafted to the polymer backbone. The method of delivering an active agent to a subject includes encapsulating the active agent with the graft copolymer and administering the encapsulated active agent to the subject.

Abstract: Systems and method for controlling wellsite equipment, including pumps and a manifold having a low-pressure (LP) manifold, having LP ports with LP valves, and a high-pressure (HP) manifold, having HP ports with HP valves and bleed ports with bleed valves. The pumps are fluidly coupled with the LP manifold via LP conduits and with the HP manifold via HP conduits. Communication is established between a controller and the LP valves, the HP valves, the bleed valves, the pumps, and sensors for monitoring pressure within the HP conduits. The controller is operable to, with respect to each pump, cause the LP valve to transition to a closed position, cause the HP and/or bleed valve to transition to an open position, and determine that the HP conduit is not pressurized based on the information generated by the sensors.

Abstract: A monitoring system operable to monitor an oilfield additive system having multiple components. The oilfield additive system is operable to transfer an additive-containing substance for injection into a wellbore. The monitoring system includes sensors each associated with, and operable to generate information related to an operational parameter of, a corresponding one of the oilfield additive system components. The monitoring system also includes a monitoring device in communication with the sensors and operable to record the information generated by the sensors to generate a database. The database includes information indicative of maintenance aspects of the oilfield additive system and/or the oilfield additive system components.

Abstract: The disclosure relates to a method for estimating the effectiveness of treatment with a T-lymphocyte cell co-stimulation modulator agent in a patient with rheumatoid arthritis and who has had an inadequate response to prior biotherapy, consisting in analysing a biological sample of said patient for the expression of a set of biomarkers, the results of which make it possible to determine whether said modulator agent is a treatment that will engender a beneficial response for said patient. The disclosure also relates to a system for estimating the effectiveness of said treatment in said patient comprising means for measuring or receiving data concerning the expression level of said biomarkers and means for processing these data configured to estimate said effectiveness of said treatment in said patient.

Abstract: Systems and method for controlling wellsite equipment, including pumps and a manifold having a low-pressure (LP) manifold, having LP ports with LP valves, and a high-pressure (HP) manifold, having HP ports with HP valves and bleed ports with bleed valves. The pumps are fluidly coupled with the LP manifold via LP conduits and with the HP manifold via HP conduits. Communication is established between a controller and the LP valves, the HP valves, the bleed valves, the pumps, and sensors for monitoring pressure within the HP conduits. The controller is operable to, with respect to each pump, cause the LP valve to transition to a closed position, cause the HP and/or bleed valve to transition to an open position, and determine that the HP conduit is not pressurized based on the information generated by the sensors.

Abstract: A method of mounting a motor to a gearbox includes positioning a coupling along an input shaft of the gearbox from a starting position to a first alignment position. In the starting position, the coupling drivingly engages a greater portion of the gearbox input shaft than in the first alignment position. In the first alignment position, the coupling operatively contacts the motor output shaft. Another step includes rotating the coupling so that the coupling aligns with the motor output shaft. Another step includes axially positioning the coupling at a second alignment position such that the coupling drivingly engages both the motor output and the gearbox input shafts. Another step includes positioning the motor to allow mounting of the motor on the gearbox with the coupling at a third alignment position drivingly engaging a greater portion of the motor output and the gearbox input shafts than in the second alignment position.

Abstract: A monitoring system operable to monitor an oilfield additive system having multiple components. The oilfield additive system is operable to transfer an additive-containing substance for injection into a wellbore. The monitoring system includes sensors each associated with, and operable to generate information related to an operational parameter of, a corresponding one of the oilfield additive system components. The monitoring system also includes a monitoring device in communication with the sensors and operable to record the information generated by the sensors to generate a database. The database includes information indicative of maintenance aspects of the oil-field additive system and/or the oilfield additive system components.

Abstract: The invention relates to a method for optimizing the data rate, in a wireless communication system comprising a LED forming an emitting device, and a photodetector forming a receiving device. For a given value of a DC component of the supply signal of the LED, the modulation amplitude of an AC component of this supply signal is adjusted step by step, so as to improve the transmission quality of the signal provided by the LED and received by the photodetector. The invention also relates to an optimization module implementing such a method. Alternatively, the modulation amplitude of the AC component of the supply signal is set, and the value of the DC component is adjusted step by step.

Abstract: A lubrication system for a gear box has a backing member. The backing member is configured to allow mounting of a plurality of lubrication components on the backing member. One of the lubrication components comprises a pump configured to pressurize lubricating oil for the lubrication system. The pump has a suction and discharge. The pump suction is removably connectable to the gear box and the pump discharge is removably connectable to piping that is configured to communicate with the gear box. The backing member has a lifting mount arranged along its length and width that corresponds to a center of gravity of the backing member with the lubrication components mounted thereto. The lubrication components are modular and may be replaced and installed as necessary on the backing member. Multiple like lubrication systems may be provided, and removed and installed on the gear box as needed for maintenance.

Abstract: A planetary gear train is lubricated via a distribution ring and a planet gear carrier oil supply passage in communication with the distribution ring. The gear train includes a sun pinion that engages a planet gear at a sun planet gear mesh. The planet gear is rotatably mounted to a planet gear carrier. The planet gear carrier is configured to drive an output shaft. The output shaft may be operatively connected to a load. The planet gear rotates within a ring gear at a planet gear ring mesh. The distribution ring surrounds a planet gear carrier and has a hollow interior that communicates with an oil supply. A planet gear carrier oil supply passage may extend through a planet gear carrier of the gear train and supply oil to a sun planet gear mesh and the planet ring gear mesh, and bearings of the planetary gear train.

Abstract: An interface device receives at least one access command with at least one corresponding slave address on a bus. The interface device reads a configuration register, and responsive to the reading of the configuration register, the interface device selects one of a plurality of interface architecture configurations. The interface architecture configurations allow the interface device to operate as either a single physical interface entity or as multiple virtual interface entities. The interface device processes the access command according to the selected interface architecture configuration.

Abstract: A lubrication system for a gear box has a backing member. The backing member is configured to allow mounting of a plurality of lubrication components on the backing member. One of the lubrication components comprises a pump configured to pressurize lubricating oil for the lubrication system. The pump has a suction and discharge. The pump suction is removably connectable to the gear box and the pump discharge is removably connectable to piping that is configured to communicate with the gear box. The backing member has a lifting mount arranged along its length and width that corresponds to a center of gravity of the backing member with the lubrication components mounted thereto. The lubrication components are modular and may be replaced and installed as necessary on the backing member. Multiple like lubrication systems may be provided, and removed and installed on the gear box as needed for maintenance.

Abstract: A method of mounting a motor to a gearbox includes positioning a coupling along an input shaft of the gearbox from a starting position to a first alignment position. In the starting position, the coupling drivingly engages a greater portion of the gearbox input shaft than in the first alignment position. In the first alignment position, the coupling operatively contacts the motor output shaft. Another step includes rotating the coupling so that the coupling aligns with the motor output shaft. Another step includes axially positioning the coupling at a second alignment position such that the coupling drivingly engages both the motor output and the gearbox input shafts. Another step includes positioning the motor to allow mounting of the motor on the gearbox with the coupling at a third alignment position drivingly engaging a greater portion of the motor output and the gearbox input shafts than in the second alignment position.

Abstract: A gear box housing has a hollow interior configured to contain a gear train. The gear train has a shaft extending from the housing hollow interior though an opening. The housing has a sump in the housing hollow interior for lubricating oil used for lubricating at least some portions of the gear train. A grease seal adjacent to the opening of housing is configured to seal around the shaft. The grease seal has a fill line that extends from an injection port located exterior of the housing, through a structural member of housing into the interior of the housing, and through the oil sump to the grease seal. The grease seal has a discharge line that extends from the grease seal, through the oil sump, and through a structural member of the housing to the exterior of the housing to a discharge port located exterior of the housing.

Abstract: A planetary gear train is lubricated via a distribution ring and a planet gear carrier oil supply passage in communication with the distribution ring. The gear train includes a sun pinion that engages a planet gear at a sun planet gear mesh. The planet gear is rotatably mounted to a planet gear carrier. The planet gear carrier is configured to drive an output shaft. The output shaft may be operatively connected to a load. The planet gear rotates within a ring gear at a planet gear ring mesh. The distribution ring surrounds a planet gear carrier and has a hollow interior that communicates with an oil supply. A planet gear carrier oil supply passage may extend through a planet gear carrier of the gear train and supply oil to a sun planet gear mesh and the planet ring gear mesh, and bearings of the planetary gear train.