Patents by Inventor Claes Juhlin

Claes Juhlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding human calcium sensor protein
    Patent number: 6239270
    Abstract: The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 29, 2001
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Göran Akerström, Claes Juhlin, Lars Rask, Göran Hjälm, Clarence C. Morse, Edward M. Murray, Gregg R. Crumley
  • Methods using human calcium sensor protein, fragments thereof and DNA encoding same
    Patent number: 6187548
    Abstract: The present invention relates to the isolation of a cDNA clone encoding the calcium sensor in human placenta and subsequent Northern blots confirming the mRNA expression also in human parathyroid and kidney tubule cells. Close sequence similarity is demonstrated with the rat Heymann nephritis antigen, a glycoprotein of the kidney tubule brush border with calcium binding ability. Immunohistochemistry substantiates a tissue distribution of the calcium sensor protein similar to that previously described for the Heymann antigen. It is proposed that the identified calcium sensor protein constitutes a universal sensor for recognition of variation in extracellular calcium, and that it plays a key role for calcium regulation via different organ systems. The calcium sensor protein belongs to the LDL-superfamily of glycoproteins, claimed to function primarily as protein receptors, but with functionally important calcium binding capacity.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: February 13, 2001
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Göran Akerström, Claes Juhlin, Lars Rask, Göran Hjälm, Clarence C. Morse, Edward M. Murray, Gregg R. Crumley
  • Antiparathyroid antibodies which specifically bind to cell surface molecules on parathyroid, renal and cytotrophoblast cells which are involved in calcium sensing
    Patent number: 5476921
    Abstract: Antibody preparations are useful in the prognosis of parathyroid and renal disorders. The antibody preparation includes antibodies which bind specifically to a surface antigen, Ca.sup.2+ sensing structure, present in humans on the parathyroid, on the proximal tubuli of the kidney, on the cytotrophoblastic cells of the placenta, on renal carcinoma cells and on parathyroid cancer cells.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: December 19, 1995
    Inventors: Claes Juhlin, Rikard Holmdahl, Lars Klareskog, Jonas Rastad, Goran Akerstrom