Patents by Inventor Claire Przybyla

Claire Przybyla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    Patent number: 7189864
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: March 13, 2007
    Assignee: G.D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Richard A. Mueller, Michael L. Vazquez, Daniel P. Getman
  • Methods of preparing retroviral proteases inhibitor intermediates
    Publication number: 20060270855
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: May 16, 2006
    Publication date: November 30, 2006
    Applicant: G.D. Searle & Co.
    Inventors: John Ng, Claire Przybyla, Shu-Hong Zhang
  • Method of preparing retroviral protease inhibitor intermediates
    Patent number: 7060851
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: June 13, 2006
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire A Przybyla, Shu-Hong Zhang
  • Method for preparing intermediates useful in synthesis of retroviral protease inhibitors
    Patent number: 6974876
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: December 13, 2005
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire A. Przybyla, Richard A Mueller, Michael L Vazquez, Daniel P Getman
  • Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    Publication number: 20050171366
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Application
    Filed: October 13, 2004
    Publication date: August 4, 2005
    Applicant: G.D. Searle & Co.
    Inventors: John Ng, Claire Przybyla, Richard Mueller, Michael Vazquez, Daniel Getman
  • Method of preparing retroviral protease inhibitor intermediates
    Publication number: 20050131075
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diasteredmerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: October 12, 2004
    Publication date: June 16, 2005
    Applicant: G.D. Searle & Co.
    Inventors: John Ng, Claire Przybyla, Shu-Hong Zhang
  • Method for the preparation of tetrahydrobenzothiepines
    Publication number: 20050090543
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Application
    Filed: May 19, 2004
    Publication date: April 28, 2005
    Applicant: Pharmacia Corporation
    Inventors: Kevin Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Farid Payman, Robert Hett, Christian Huber, Kevin Koeller, Jon Lawson, James Li, Eduardo Mar, Lawrence Miller, Vladislav Orlovski, James Peterson, Mark Pozzo, Claire Przybyla, Samuel Tremont, Jay Trivedi, Grace Wagner, Gerald Weisenburger, Benxin Zhi
  • Process for making alpha-substituted hydroxamic acids
    Publication number: 20050043533
    Abstract: This invention is directed generally to a process for making ?-substituted hydroxamic acids (including salts thereof) generally corresponding in structure to Formula (I): wherein n, Z, Z3, A, R, E, and Y are as defined in this patent. This invention also is directed to compounds that may, for example, be used as intermediates in such a process, as well as processes for making such compounds.
    Type: Application
    Filed: March 24, 2004
    Publication date: February 24, 2005
    Inventors: Kevin Babiak, Terri Boehm, Pierre-Jean Colson, Payman Farid, Donald Gallagher, Christian Huber, Russell Linderman, Chin Liu, Eduardo Mar, Murad Newaz, Daniel Pippel, Claire Przybyla, Christopher Robb, Glenn Stahl, Ravindra Topgi, Gerald Weisenburger, Edward Yonan
  • Method for the preparation of tetrahydrobenzothiepines
    Patent number: 6794544
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: September 21, 2004
    Assignee: Pharmacia Corporation
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi
  • Method for the preparation of tetrahydrobenzothiepines
    Publication number: 20040082647
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Application
    Filed: April 21, 2003
    Publication date: April 29, 2004
    Applicant: G.D. SEARLE, LLC
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi
  • Method for the preparation of tetrahydrobenzothiepines
    Publication number: 20030236406
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Application
    Filed: December 23, 2002
    Publication date: December 25, 2003
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi
  • Method for preparing intermediates useful in synthesis of retroviral protease inhibitors
    Publication number: 20030225285
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Application
    Filed: February 10, 2003
    Publication date: December 4, 2003
    Applicant: G.D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Richard A. Mueller, Michael L. Vazquez, Daniel P. Getman
  • Method of preparing retroviral protease inhibitor intermediates
    Publication number: 20030171612
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: December 23, 2002
    Publication date: September 11, 2003
    Applicant: G.D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Shu-Hong Zhang
  • Method for the preparation of tetrahydrobenzothiepines
    Patent number: 6586434
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: July 1, 2003
    Assignee: G.D. Searle, LLC
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi
  • Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    Patent number: 6570027
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: May 27, 2003
    Assignee: G. D. Searle & Co.
    Inventors: John S Ng, Claire A. Przybyla, Richard A Mueller, Michael L Vazquez, Daniel P Getman
  • Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
    Publication number: 20020161234
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Application
    Filed: April 3, 2002
    Publication date: October 31, 2002
    Applicant: G.D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Richard A. Mueller, Michael L. Vazquez, Daniel P. Getman
  • Method for making intermediates useful in synthesis of retroviral protease inhibitors
    Patent number: 6388094
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: May 14, 2002
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire A. Przybyla, Richard A Mueller, Michael L Vazquez, Daniel P Getman
  • Method for the preparation of tetrahydrobenzothiepines
    Publication number: 20020032329
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Application
    Filed: March 8, 2001
    Publication date: March 14, 2002
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi
  • Method of preparing retroviral protease inhibitor intermediates
    Publication number: 20010047111
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Application
    Filed: December 21, 2000
    Publication date: November 29, 2001
    Inventors: John S. Ng, Claire A. Przybyla, Shu-Hong Zhang
  • Method for making intermediates useful in synthesis of retroviral protease inhibitors
    Patent number: 6022996
    Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: February 8, 2000
    Assignee: G. D. Searle & Co.
    Inventors: John S. Ng, Claire A. Przybyla, Richard A Mueller, Michael L. Vazquez, Daniel P. Getman