Abstract: The present invention relates to a vaccine composition for preventing severe acute respiratory syndrome coronavirus 2 infection. The vaccine composition for preventing severe acute respiratory syndrome coronavirus 2 infection according to the present invention comprises spike and ORF3a or nucleocapsid as an antigen against SARS-CoV-2. The vaccine composition has a significant effect of inducing antibody immune responses and T-cell immune responses by a plurality of co-expressed antigens compared to those comprising one antigen, and thus can be variously used in the field of prevention of severe acute respiratory syndrome coronavirus 2 infection.

Abstract: Storage pouch devices for use with a woman's bra. The storage pouch includes a front panel, a rear panel, and a cavity defined between the front and rear panels. The internal cavity is bounded by portions of the outer perimeters of both the front and rear panels that are attached together. The storage pouch is advantageously shaped and sized so as to be substantially or entirely concealable beneath one of a user's bra cups. The pouch further includes means attached to at least one of the panels (e.g., the front panel) for engaging a bra strap or bra cup so as to secure the storage pouch to a woman's bra strap or cup. The attachment means is specifically configured so that inconspicuous engagement and disengagement (and removal) of the storage pouch is possible by simply sliding the bra strap or cup into or out of engagement with the attachment means.

Abstract: The present invention is predicated on the discovery of certain interactions between cellular growth factors and opposing actions that control differentiation and migration or invasion of cytotrophoblasts into the uterine endometrium during pregnancy. IGF-II and latent transforming growth factor beta (TGF?), the inactive precursor of TGF?, compete for binding to the CIM6P receptor. IGF-II prevents latent TGF? binding to the CIM6P receptor. The invention therefore offers a method of regulating and directing cytotrophoblast differentiation and function based on the interaction between IGF-II, latent TGF? and the CIM6P receptor. There is disclosed a method of regulating cytotrophoblast and stem cell differentiation and migration characterized by adjusting levels of insulin-like growth factor II (IGF-II) available for binding to the cation-independent mannose-6-phosphate (CIM6P) receptor. The discovery may be applied to embryonic or adult stem cells to control their differentiation and migratory behaviour.

Abstract: The present invention is predicated on the discovery of certain interactions between cellular growth factors and opposing actions that control differentiation and migration or invasion of cytotrophoblasts into the uterine endometrium during pregnancy. IGF-II and latent transforming growth factor beta (TGF?), the inactive precursor of TGF?, compete for binding to the CIM6P receptor. IGF-II prevents latent TGF? binding to the CIM6P receptor. The invention therefore offers a method of regulating and directing cytotrophoblast differentiation and function based on the interaction between IGF-II, latent TGF? and the CIM6P receptor. There is disclosed a method of regulating cytotrophoblast and stem cell differentiation and migration characterized by adjusting levels of insulin-like growth factor II (IGF-II) available for binding to the cation-independent mannose-6-phosphate (CIM6P) receptor. The discovery may be applied to embryonic or adult stem cells to control their differentiation and migratory behaviour.