Patents by Inventor Clark Q. Pan

Clark Q. Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant Heme Oxygenase-1 (HO-1) for the Treatment of Sickle Cell Disease
    Publication number: 20230018417
    Abstract: The present invention provides, among other things, methods and compositions for making and using recombinant heme oxygenase for treating sickle cell disease. In some embodiments, recombinant heme oxygenase proteins are truncation variants, or Fc fusion proteins with increased half-life and/or reduced aggregation.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 19, 2023
    Inventors: Solomon Fiifi Ofori-Acquah, Samit Ghosh, Joseph Sypek, Bohong Zhang, Xiuxia Sun, Clark Q. Pan, Daniel Minard Lajole, Chuan Shen
  • OLIGOSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20220242899
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: February 14, 2022
    Publication date: August 4, 2022
    Inventors: Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG
  • Oligosaccharide-protein conjugates
    Patent number: 11279725
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: March 22, 2022
    Assignee: Genzyme Corporation
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • OLIGOSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20200216485
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: September 24, 2019
    Publication date: July 9, 2020
    Inventors: Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG
  • Oligosaccharide-protein conjugates
    Patent number: 10464962
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: November 5, 2019
    Assignee: GENZYME CORPORATION
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • Peptide analogs of alpha-melanocyte stimulating hormone
    Patent number: 10385108
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: August 20, 2019
    Assignee: GENZYME CORPORATION
    Inventors: Michael A. Perricone, John Lyle Dzuris, Timothy E. Weeden, James E. Stefano, Clark Q. Pan, Andrea E. Edling
  • OLIGOSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20180002365
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: October 7, 2016
    Publication date: January 4, 2018
    Inventors: Luis Z. AVILA, Clark Q. PAN, Patrick FINN, John HARRAHY, Qun ZHOU, Yunxiang ZHU, Paul A. KONOWICZ, Duncan E. PATERSON, Andreas PEER, Joseph P. KUTZKO, Michael R. REARDON, James E. STEFANO, Xiaoyang ZHENG, Robert J. MILLER, Lauren YOUNG
  • PEPTIDE ANALOGS OF ALPHA-MELANOCYTE STIMULATING HORMONE
    Publication number: 20170313756
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Application
    Filed: July 10, 2017
    Publication date: November 2, 2017
    Applicant: Genzyme Corporation
    Inventors: Michael A. PERRICONE, John Lyle DZURIS, Timothy E. WEEDEN, James E. STEFANO, Clark Q. PAN, Andrea E. EDLING
  • Peptide analogs of alpha-melanocyte stimulating hormone
    Patent number: 9738698
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: August 22, 2017
    Assignee: GENZYME CORPORATION
    Inventors: Michael A. Perricone, John Lyle Dzuris, Timothy E. Weeden, James E. Stefano, Clark Q. Pan, Andrea E. Edling
  • Oligosaccharide-protein conjugates
    Patent number: 9493498
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 15, 2016
    Assignee: GENZYME CORPORATION
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • Factor VIII conjugates
    Patent number: 9364520
    Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: June 14, 2016
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Clark Q. Pan, John E. Murphy, Baisong Mei, Jonathan S. Strauss, Hendri Tjandra, Jianmin Chen, Thomas Barnett, Liang Tang, Deqian Wang
  • METHODS OF TREATING HEMOPHILIA IN PATIENTS HAVING DEVELOPED INHIBITORY ANTIBODIES
    Publication number: 20160051633
    Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
    Type: Application
    Filed: July 20, 2015
    Publication date: February 25, 2016
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Clark Q. PAN, John E. MURPHY, Baisong MEI, Jonathan S. STRAUSS, Hendri TJANDRA, Jianmin CHEN, Thomas BARNETT, Liang TANG, Deqian WANG
  • PEPTIDE ANALOGS OF ALPHA-MELANOCYTE STIMULATING HORMONE
    Publication number: 20160046688
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Application
    Filed: August 19, 2015
    Publication date: February 18, 2016
    Applicant: GENZYME CORPORATION
    Inventors: Michael A. PERRICONE, John Lyle DZURIS, Timothy E. WEEDEN, James E. STEFANO, Clark Q. PAN, Andrea E. EDLING
  • Peptide analogs of alpha-melanocyte stimulating hormone
    Patent number: 9115174
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: August 25, 2015
    Assignee: Genzyme Corporation
    Inventors: Michael A. Perricone, John Lyle Dzuris, Timothy E. Weeden, James E. Stefano, Clark Q. Pan, Andrea E. Edling
  • Factor VIII conjugates
    Patent number: 9096656
    Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: August 4, 2015
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Clark Q. Pan, John E. Murphy, Baisong Mei, Jonathan S. Strauss, Hendri Tjandra, Jianmin Chen, Thomas Barnett, Liang Tang, Deqian Wang
  • OLIGOSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20150175643
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Application
    Filed: July 29, 2014
    Publication date: June 25, 2015
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • Oligosaccharide-protein conjugates
    Patent number: 8835614
    Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: September 16, 2014
    Assignee: Genzyme Corporation
    Inventors: Luis Z. Avila, Clark Q. Pan, Patrick Finn, John Harrahy, Qun Zhou, Yunxiang Zhu, Paul A. Konowicz, Duncan E. Paterson, Andreas Peer, Joseph P. Kutzko, Michael R. Reardon, James E. Stefano, Xiaoyang Zheng, Robert J. Miller, Lauren Young
  • PEGYLATED APELIN AND USES THEREOF
    Publication number: 20140142049
    Abstract: The invention provides compositions and methods for treating a disease or disorder associated with Apelin. Specifically, the invention relates to a pegylated form of Apelin to provide extended circulating life and inotropic effects, and thereby efficiently treat diseases or disorders associated with Apelin.
    Type: Application
    Filed: March 8, 2012
    Publication date: May 22, 2014
    Inventors: Zhiqiang Jia, Lihui Hou, Clark Q Pan, Geoffrey Akita
  • PEPTIDE ANALOGS OF ALPHA-MELANOCYTE STIMULATING HORMONE
    Publication number: 20130303452
    Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (?-MSH) having selectivity for the melanocortin 1 receptor (MC1R). Also provided herein are pharmaceutical preparations of the ?-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MC1R.
    Type: Application
    Filed: May 8, 2013
    Publication date: November 14, 2013
    Inventors: Michael A. PERRICONE, John Lyle DZURIS, Timothy E. WEEDEN, James E. STEFANO, Clark Q. PAN, Andrea E. EDLING
  • FACTOR VIII CONJUGATES
    Publication number: 20130274445
    Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
    Type: Application
    Filed: January 24, 2013
    Publication date: October 17, 2013
    Inventors: Clark Q Pan, John E. Murphy, Baisong Mei, Jonathan S. Strauss, Hendri Tjandra, Jianmin Chen, Thomas Barnett, Liang Tang, Deqian Wang