Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: A wheel clamp (2) for fastening to a wheel (1), in particular to a wheel (1) of a motor vehicle, comprises at least two arms (22, 23, 24) which extend outward from a center (28) of the wheel clamp (2) in a radial direction. Each of the arms (22, 23, 24) has at least one movable element (32, 33, 34) which is movable in the radial direction. The wheel clamp (2) comprises a locking member (82) which is designed such that the movable elements (32, 33, 34), by operation of the locking member (82), can be fixed such that the movable elements (32, 33, 34) are no longer movable in the radial direction. The wheel clamp (2) also comprises an unlocking member (84) which is designed such that a fixation of the movable elements (32, 33, 34) can be released by operation of the unlocking member (84).

Abstract: A wheel holder (2) for fastening to a wheel (1), in particular to a wheel (1) of a motor vehicle, comprises at least two arms (22, 23, 24) extending outward from a center (28) of the wheel holder (2) in a radial direction; each of the arms (22, 23, 24) having at least one movable element (32, 33, 34) that is movable in the radial direction; a rotation element (40) that is arranged in the center (28) of the wheel holder (2) such that it can rotate; at least two coupling elements (52, 53, 54) each extending between one of the movable elements (32, 33, 34) and the central rotation element (40) such that the movable elements (32, 33, 34) are movable in the radial direction by rotation of the rotation element (40); and at least one drive device (63, 64) which is connected to one of the movable elements (32, 33, 34) via a force transmitting element (73, 74) and which is designed to apply, via the force transmitting element (73,74), a force to the movable element (32, 33, 34) that is directed towards the center (28)

Abstract: A wheel holder for fastening to a wheel comprises at least two arms extending outward from a base plate of the wheel holder radially; each of the arms having at least one movable element that is movable radially; a central rotation element that is arranged in the center of the wheel holder such that it can rotate; and at least two coupling elements each extending between one of the movable elements and the central rotation element such that the movable elements are movable radially by rotation of the rotation element. The rotation element is attached to the base plate of the wheel holder via a freewheeling system. The freewheeling system has at least one operating state in which the rotation element is rotatable in a freewheeling direction and rotation of the rotation element in a blocking direction opposite to the freewheeling direction is blocked.

Abstract: A wheel clamp (2) for fastening to a wheel (1), in particular to a wheel (1) of a motor vehicle, comprises at least two arms (22, 23, 24) which extend outward from a center (28) of the wheel clamp (2) in a radial direction. Each of the arms (22, 23, 24) has at least one movable element (32, 33, 34) which is movable in the radial direction. The wheel clamp (2) comprises a locking member (82) which is designed such that the movable elements (32, 33, 34), by operation of the locking member (82), can be fixed such that the movable elements (32, 33, 34) are no longer movable in the radial direction. The wheel clamp (2) also comprises an unlocking member (84) which is designed such that a fixation of the movable elements (32, 33, 34) can be released by operation of the unlocking member (84).

Abstract: A wheel clamp (2) for fastening to a wheel (1), in particular to a wheel (1) of a motor vehicle, comprises at least two arms (22, 23, 24) which extend outward from a center (28) of the wheel clamp (2) in a radial direction, and a central rotary element (40) which is rotatably arranged in the center (28) of the wheel clamp (2). Each arm (22, 23, 24) has at least one movable element (32, 33, 34) which is movable in the radial direction in order to permit varying the length of the arm (22, 23, 24) in the radial direction. The wheel clamp (2) comprises furthermore at least two coupling elements (52, 53, 54) which each extend between one of the movable elements (32, 33, 34) and the central rotary element (40) such that the movable elements (32, 33, 34) are movable in the radial direction by rotation of the rotary element (40).

Abstract: A vehicle measurement system includes a laser projector which is designed to generate suitable laser radiation during the vehicle measurement operation, and a laser protection device which is suitable for protecting people and objects from the laser radiation. The laser projector and the laser protection device are designed as separate components and are combinable to form a laser projector having a laser protection device and are separable from one another again.

Abstract: A vehicle measurement system includes a laser projector which is designed to generate suitable laser radiation during the vehicle measurement operation, and a laser protection device which is suitable for protecting people and objects from the laser radiation. The laser projector and the laser protection device are designed as separate components and are combinable to form a laser projector having a laser protection device and are separable from one another again.

Abstract: A thermocycler comprising a temperature control block (1,2,3) which is designed to receive several specimens and which is fitted with a control unit (6) that in consecutive cycles applies the different temperature levels (40° C., 70° C., 95° C.) of a PCR procedure to said block, said thermocycler being characterized in that said temperature controlling block is sub-divided into thermally separate segments (1,2,3) each of which is controlled separately and receives several specimens, the control unit (6) being designed to drive the said segments at different cycling rates (nine, seven, four).

Abstract: A thermocycler comprising a temperature control block (1,2,3) which is designed to receive several specimens and which is fitted with a control unit (6) that in consecutive cycles applies the different temperature levels (40° C., 70° C., 95° C.) of a PCR procedure to said block, said thermocycler being characterized in that said temperature controlling block is sub-divided into thermally separate segments (1,2,3) each of which is controlled separately and receives several specimens, the control unit (6) being designed to drive the said segments at different cycling rates (nine, seven, four).

Abstract: A thermocycler comprising a temperature control block (1,2,3) which is designed to receive several specimens and which is fitted with a control unit (6) that in consecutive cycles applies the different temperature levels (40° C., 70° C., 95° C.) of a PCR procedure to said block, said thermocycler being characterized in that said temperature controlling block is sub-divided into thermally separate segments (1, 2, 3) each of which is controlled separately and receives several specimens, the control unit (6) being designed to drive the said segments at different cycling rates (nine, seven, four).