Abstract: The invention provides an amorphous metal-organic framework for use in methods of treatment. The amorphous metal-organic framework may hold a component for delivery. The amorphous metal-organic framework is obtained or is obtainable by amorphization of a crystalline amorphous metal-organic framework holding the component. The amorphous metal-organic framework may be a zirconium-containing or a bismuth-containing metal-organic framework, such as a framework having arylcarboxylate ligands, such as benzenedicarboxylate ligands.

Abstract: The invention provides an amorphous metal-organic framework for use in methods of treatment. The amorphous metal-organic framework may hold a component for delivery. The amorphous metal-organic framework is obtained or is obtainable by amorphization of a crystalline amorphous metal-organic framework holding the component. The amorphous metal-organic framework may be a zirconium-containing or a bismuth-containing metal-organic framework, such as a framework having arylcarboxylate ligands, such as benzenedicarboxylate ligands.

Abstract: Apparatuses for performing minimally invasive medical procedures are disclosed herein. In one example, an apparatus includes an outer body that defines an opening at a distal end, and a cutting portion disposed at an edge of the opening. An inner body is movably disposed within the outer body and defines an opening at a distal end. The outer body and the inner body collectively have a first configuration in which the opening on the outer body is substantially aligned with the opening on the inner body and the opening on the outer body is configured to receive a portion of a tissue, and a second configuration in which the opening on the outer body and the opening on the inner body are substantially misaligned and the cutting portion on the outer body is configured to sever the portion of the tissue from a remaining portion of the tissue.

Abstract: Apparatuses and methods for performing minimally invasive medical procedures are disclosed herein. In one example, an apparatus includes an elongate body that has a deformable distal portion and defines a lumen, the lumen extends through the deformable distal portion. The deformable distal portion has a cutting portion and defines an opening. The elongate body has a first configuration in which the opening is a first size and a second configuration in which the opening is a second size smaller than the first size of the opening. The elongate body in the first configuration is configured to be percutaneously inserted at least partially into a tissue such that at least a portion of the tissue is disposed within the lumen. The elongate body is configured to move to the second configuration when the elongate body reaches a threshold temperature while inserted in the tissue.