Patents by Inventor Claus Selch LARSEN

Claus Selch LARSEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazole derivatives as prodrugs of diclofenac
    Patent number: 10266499
    Abstract: The present invention relates to a compound of formula (I): wherein R1 is R3—IPU and R2 is the acyloxy residue of diclofenac, and specified by the following structures: wherein OH—R3—IPU is selected from and R4 and R5 may be the same or different selected from H and CH3 and salts, solvates and hydrates thereof.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: April 23, 2019
    Inventor: Claus Selch Larsen
  • Prodrugs of naproxen and diclofenac
    Patent number: 9937262
    Abstract: The present invention relates to a compound of formula (I): wherein R1 is R3-IPU and R2 is the acyloxy residue of diclofenac or naproxen, and specified by the following structures (A) wherein OH—R3-IPU is selected from (B) and R4 and R5 may be the same or different selected from (C) and salts, solvates and hydrates thereof.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: April 10, 2018
    Inventor: Claus Selch Larsen
  • IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC
    Publication number: 20170334862
    Abstract: The present invention relates to a compound of formula (I): wherein R1 is R3-IPU and R2 is the acyloxy residue of diclofenac, and specified by the following structures: wherein OH—R3-IPU is selected from and R4 and R5 may be the same or different selected from H and CH3 and salts, solvates and hydrates thereof.
    Type: Application
    Filed: October 27, 2015
    Publication date: November 23, 2017
    Inventor: Claus Selch Larsen
  • Prodrugs of non-steroid anti-inflammatory agents (NSAIDS)
    Patent number: 9809557
    Abstract: The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: November 7, 2017
    Inventor: Claus Selch Larsen
  • PRODRUGS OF NAPROXEN AND DICLOFENAC
    Publication number: 20160074523
    Abstract: The present invention relates to a compound of formula (I): wherein R1 is R3-IPU and R2 is the acyloxy residue of diclofenac or naproxen, and specified by the following structures (A) wherein OH—R3-IPU is selected from (B) and R4 and R5 may be the same or different selected from (C) and salts, solvates and hydrates thereof.
    Type: Application
    Filed: April 28, 2014
    Publication date: March 17, 2016
    Inventor: Claus Selch LARSEN
  • PRODRUGS OF NON-STEROID ANTI-INFLAMMATORY AGENTS (NSAIDS)
    Publication number: 20140315960
    Abstract: The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 23, 2014
    Inventor: Claus Selch LARSEN