Patents by Inventor Clemens Michael Helmut Brechtelsbauer

Clemens Michael Helmut Brechtelsbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof
    Patent number: 7199242
    Abstract: The invention provides a process for the production of a compound of formula (I): wherein P1 and P2, which may be the same or different, are amino protecting groups, which comprises protection of a compound of formula (II) in solution phase continuous operation mode. This confers advantages over batch mode operation. The process is usually conducted in reaction equipment adapted for use in continuous processing mode, for example comprising one or more static mixers or a plug flow reactor. Preferably, the plug flow reactor comprises a jacketed tubular reactor fitted inside with internal mixing elements which continually split and remix the reaction streams promoting mass and heat transfer, whereby a uniform plug flow profile with turbulent fluid flow is achieved. The invention also provides a process for production of the antibacterial compound gemifloxacin or a pharmaceutically acceptable salt and/or hydrate thereof, comprising converting a compound of formula (I).
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: April 3, 2007
    Assignee: LG Life Sciences Limited
    Inventors: Clemens Michael Helmut Brechtelsbauer, Stephen Thomas Carpenter, Trevor John Grinter, Michael Anthony Harris, Yeongdae Kim, Youngwoon Kwon, Dongchul Lee, François Xavier Ricard, Richard Neville Saunders
  • Process for epoxidizing substituted cyclohexanones
    Patent number: 6482960
    Abstract: This invention relates to a method for preparing 1-oxaspiro[2,5]-carbonitriles from ketones using spinning disc reactor technology.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: November 19, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Clemens Michael Helmut Brechtelsbauer, Paul Oxley