Patents by Inventor Cliff R. Wong

Cliff R. Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multistage nanoparticle drug delivery system for the treatment of solid tumors
    Patent number: 9919059
    Abstract: Nanoparticles for a selective, two stage delivery to tumors have been developed. The nanoparticles are initially sized so that they preferentially accumulate in the tumor tissue as a result of leakage through the defective vascular in the solid tumors. Once in the tumor tissue, the nanoparticles are cleaved hydrolytically and/or by enzymatic cleavage over time to release smaller nanoparticles carrying therapeutic, prophylactic or diagnostic agents into the necrotic interior of the tumors. This provides a simple, elegant and highly effective means of delivery drug selectively not just to tumors generally, but, more importantly, into the poorly vascularized necrotic interiors which drugs are normally unable to penetrate. The nanoparticles have a number of advantages: less toxicity due to selective accumulation only in the tumors; access into the poorly vascularized necrotic interiors of the tumor; and sustained release over a period of time within the tumor.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: March 20, 2018
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Cliff R. Wong, Moungi G. Bawendi, Dai Fukumura, Rakesh K. Jain
  • Electrically controlled catalytic nanowire growth based on surface charge density
    Patent number: 9643252
    Abstract: A population of nanowires can be prepared by a method involving electric field catalyzed growth and alteration based on surface charge density.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: May 9, 2017
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: August Dorn, Cliff R. Wong, Moungi G. Bawendi
  • Multistage Nanoparticle Drug Delivery System for the Treatment of Solid Tumors
    Publication number: 20140161884
    Abstract: Nanoparticles for a selective, two stage delivery to tumors have been developed. The nanoparticles are initially sized so that they preferentially accumulate in the tumor tissue as a result of leakage through the defective vascular in the solid tumors. Once in the tumor tissue, the nanoparticles are cleaved hydrolytically and/or by enzymatic cleavage over time to release smaller nanoparticles carrying therapeutic, prophylactic or diagnostic agents into the necrotic interior of the tumors. This provides a simple, elegant and highly effective means of delivery drug selectively not just to tumors generally, but, more importantly, into the poorly vascularized necrotic interiors which drugs are normally unable to penetrate. The nanoparticles have a number of advantages: less toxicity due to selective accumulation only in the tumors; access into the poorly vascularized necrotic interiors of the tumor; and sustained release over a period of time within the tumor.
    Type: Application
    Filed: December 10, 2013
    Publication date: June 12, 2014
    Applicants: The Massachusetts General Hospital, Massachusetts Institute of Technology
    Inventors: Cliff R. Wong, Moungi G. Bawendi, Dai Fukumura, Rakesh K. Jain
  • ELECTRICALLY CONTROLLED CATALYTIC NANOWIRE GROWTH
    Publication number: 20100148152
    Abstract: A population of nanowires can be prepared by a method involving electric field catalyzed growth and alteration based on surface charge density.
    Type: Application
    Filed: December 1, 2009
    Publication date: June 17, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: August Dorn, Cliff R. Wong, Moungi G. Bawendi