Patents by Inventor Clifford J. Herman
Clifford J. Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11096887Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.Type: GrantFiled: October 14, 2019Date of Patent: August 24, 2021Assignee: SpecGX LLCInventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
-
Patent number: 11065246Abstract: A pharmaceutical composition comprising at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, a glucomannan, a first polyalkylene oxide having an average molecular weight of no more than 300,000, and a second polyalkylene oxide having an average molecular weight of at least 1,000,000 and methods of making. The pharmaceutical composition provides extended release of the API and has abuse deterrent features.Type: GrantFiled: January 27, 2017Date of Patent: July 20, 2021Assignee: SpecGX LLCInventors: Brad L. Gower, Jae Han Park, Clifford J. Herman, Tsz Chung Lai, Kai Feng
-
Publication number: 20200038317Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.Type: ApplicationFiled: October 14, 2019Publication date: February 6, 2020Inventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
-
Patent number: 10485753Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.Type: GrantFiled: January 31, 2017Date of Patent: November 26, 2019Assignee: SpecGX LLCInventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
-
Publication number: 20180280289Abstract: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.Type: ApplicationFiled: June 7, 2018Publication date: October 4, 2018Inventors: Siva N. Raman, Jae Han Park, Thomas A. Diezi, Clifford J. Herman, Sunil K. Battu, Eric A. Burge
-
Publication number: 20180256493Abstract: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.Type: ApplicationFiled: May 11, 2018Publication date: September 13, 2018Inventors: Siva N. Raman, Jae Han Park, Thomas A. Diezi, Clifford J. Herman, Sunil K. Battu, Eric A. Burge
-
Patent number: 9993422Abstract: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.Type: GrantFiled: April 18, 2013Date of Patent: June 12, 2018Assignee: SpecGX LLCInventors: Siva N. Raman, Jae Han Park, Thomas A. Diezi, Clifford J. Herman, Sunil K. Battu, Eric A. Burge
-
Publication number: 20180008532Abstract: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.Type: ApplicationFiled: September 25, 2017Publication date: January 11, 2018Inventors: Siva N. Raman, Jae Han Park, Thomas A. Diezi, Clifford J. Herman, Sunil K. Battu, Eric A. Burge
-
Patent number: 9814844Abstract: A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae.Type: GrantFiled: August 27, 2013Date of Patent: November 14, 2017Assignee: COVIDIEN LPInventors: Rachit Ohri, Lan Pham, Phillip D. Blaskovich, Les Hull, Rupal Ayer, Stephen H. Wu, Clifford J. Herman, William H. Nau, Jr., Francesca Rossetto, Allison Waller, Wenxing Huang, Paul DiCarlo, Mantao Xu, Xingyan Lu, Jiagui Li, Qinlin Gu, Harold M. Martins
-
Patent number: 9730885Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.Type: GrantFiled: July 11, 2013Date of Patent: August 15, 2017Assignee: Mallinckrodt LLCInventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
-
Publication number: 20170224826Abstract: A pharmaceutical composition comprising at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, a glucomannan, a first polyalkylene oxide having an average molecular weight of no more than 300,000, and a second polyalkylene oxide having an average molecular weight of at least 1,000,000 and methods of making. The pharmaceutical composition provides extended release of the API and has abuse deterrent features.Type: ApplicationFiled: January 27, 2017Publication date: August 10, 2017Inventors: Brad L. Gower, Jae Han Park, Clifford J. Herman, Tsz Chung Lai, Kai Feng
-
Publication number: 20170143699Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.Type: ApplicationFiled: January 31, 2017Publication date: May 25, 2017Inventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
-
Publication number: 20170087345Abstract: A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen.Type: ApplicationFiled: December 14, 2016Publication date: March 30, 2017Inventors: RACHIT OHRI, LAN PHAM, PHILLIP D. BLASKOVICH, LES HULL, RUPAL AYER, STEPHEN H. WU, CLIFFORD J. HERMAN, WILLIAM H. NAU, JR., FRANCESCA ROSSETTO, ALLISON WALLER, WENXING HUANG, PAUL DICARLO
-
Patent number: 9526568Abstract: A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen.Type: GrantFiled: August 27, 2013Date of Patent: December 27, 2016Assignee: COVIDIEN LPInventors: Rachit Ohri, Lan Pham, Phillip D. Blaskovich, Les Hull, Rupal Ayer, Stephen H. Wu, Clifford J. Herman, William H. Nau, Jr., Francesca Rossetto, Allison Waller, Wenxing Huang, Paul Dicarlo
-
Patent number: 9168227Abstract: A microsphere and methods for forming the same are disclosed. The microsphere includes modified cellulose and at least one first microsphere disposed within a multi-encapsulating microsphere, the at least one first microsphere comprising at least one first hydrogel precursor; and at least one second microsphere disposed within the multi-encapsulating microsphere, the at least one second microsphere comprising at least one second hydrogel precursor cross-linkable with the at least one first hydrogel precursor upon degradation of the at least one first microsphere and the at least one second microsphere.Type: GrantFiled: September 12, 2013Date of Patent: October 27, 2015Assignee: Covidien LPInventors: Phillip D. Blaskovich, Clifford J. Herman, Gary A. Nichols, Rachit Ohri, Lan Pham
-
Publication number: 20150065944Abstract: A drug-delivery device includes a body configured for attachment to a handle of an ablation device, a shaft portion defining a passageway therein, and a delivery lumen to provide for drug delivery to tissue. The body includes a proximal portion, a distal portion, and a contoured portion disposed therebetween. The contoured portion is configured for engagement with a contoured portion of the handle of the ablation device. The shaft portion includes a proximal end and a distal end. The proximal end of the shaft engages with an opening defined in the distal end of the body. The passageway of the shaft portion is configured to receive the delivery lumen slideably moveably therein. The delivery lumen includes a proximal portion and a distal portion. The drug-delivery device also includes a knob member coupled to the proximal portion of the delivery lumen.Type: ApplicationFiled: August 27, 2013Publication date: March 5, 2015Applicant: COVIDIEN LPInventors: RACHIT OHRI, LAN PHAM, PHILLIP D. BLASKOVICH, LES HULL, RUPAL AYER, STEPHEN H. WU, CLIFFORD J. HERMAN, WILLIAM H. NAU, JR., FRANCESCA ROSSETTO, ALLISON WALLER, WENXING HUANG, PAUL DICARLO
-
Publication number: 20150065964Abstract: A drug-delivery cannula assembly includes a cannula housing adapted for receiving at least one obturator shaft of an obturator assembly therethrough, one or more cannulae, and a supply line coupled to the cannula housing. The cannula housing is adapted for receiving one or more obturator shafts of an obturator assembly therethrough. The one or more cannulae define a longitudinal axis and a passageway aligned with the longitudinal axis. The one or more cannulae each include a proximal end coupled to the cannula housing. The cannula housing is configured to fluidly-couple the one or more cannulae to a source of a drug delivery supply for supplying drugs via the supply line to the one or more cannulae.Type: ApplicationFiled: August 27, 2013Publication date: March 5, 2015Applicant: COVIDIEN LPInventors: RACHIT OHRI, LAN PHAM, PHILLIP D. BLASKOVICH, LES HULL, RUPAL AYER, STEPHEN H. WU, CLIFFORD J. HERMAN, WILLIAM H. NAU, JR., FRANCESCA ROSSETTO, ALLISON WALLER, WENXING HUANG, PAUL DICARLO, MANTAO XU, XINGYAN LU, JIAGUI LI, QINLIN GU, HAROLD M. MARTINS
-
Publication number: 20140079790Abstract: A microsphere and methods for forming the same are disclosed. The microsphere includes modified cellulose and at least one of precursors for is-situ polymerization or endothermic/exothermic reactions.Type: ApplicationFiled: September 12, 2013Publication date: March 20, 2014Applicant: Confluent Surgical, Inc.Inventors: Phillip D. Blaskovich, Clifford J. Herman, Gary A. Nichols, Rachit Ohri, Lan Pham
-
Publication number: 20140017310Abstract: The present disclosure provides pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Also provided are methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.Type: ApplicationFiled: July 11, 2013Publication date: January 16, 2014Inventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
-
Publication number: 20130324911Abstract: An ablation system includes a source of electrosurgical energy, a source of coolant fluid, and an ablation electrode assembly operatively connected to the source of electrosurgical energy and fluidly-coupled to the source of coolant fluid. The ablation electrode assembly includes a hub defining a chamber therein and one or more electrically-conductive ablation needles extending from the hub. The ablation system also includes one or more delivery needles extending from the hub. The one or more delivery needles are selectively moveable from a first position, wherein the distal end of the delivery needle is disposed proximal to the distal end portion of the ablation needle, to at least a second position, wherein at least the distal end of the delivery needle is disposed distally beyond the distal end portion of the ablation needle.Type: ApplicationFiled: May 29, 2013Publication date: December 5, 2013Applicant: COVIDIEN LPInventors: RACHIT OHRI, LAN PHAM, PHILLIP D. BLASKOVICH, LES HULL, RUPAL AYER, STEPHEN H. WU, CLIFFORD J. HERMAN, WILLIAM H. NAU, Jr., FRANCESCA ROSSETTO, ALLISON WALLER, RICHARD HUANG, PAUL DICARLO