Patents by Inventor Clifford Leslie Smith

Clifford Leslie Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and kits for reducing non-specific nucleic acid amplification
    Patent number: 8507662
    Abstract: Methods and kits for efficient amplification of nucleic acids are provided. The methods comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having terminal mismatch primer-dimer structure. The methods also comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods enhance efficiency of nucleic acid amplification reaction by reducing non-specific amplification reactions.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: August 13, 2013
    Assignee: General Electric Company
    Inventors: John Richard Nelson, Robert Scott Duthie, Sonali Jagdish Shah, Clifford Leslie Smith
  • METHODS AND KITS FOR REDUCING NON-SPECIFIC NUCLEIC ACID AMPLIFICATION
    Publication number: 20110287510
    Abstract: Methods and kits for efficient amplification of nucleic acids are provided. The methods comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having terminal mismatch primer-dimer structure. The methods also comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods enhance efficiency of nucleic acid amplification reaction by reducing non-specific amplification reactions.
    Type: Application
    Filed: July 15, 2011
    Publication date: November 24, 2011
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: John Richard Nelson, Robert Scott Duthie, Sonali Jagdish Shah, Clifford Leslie Smith
  • Methods and kits for reducing non-specific nucleic acid amplification
    Patent number: 7993839
    Abstract: Methods and kits for efficient amplification of nucleic acids are provided. The methods comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having terminal mismatch primer-dimer structure. The methods also comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods enhance efficiency of nucleic acid amplification reaction by reducing non-specific amplification reactions.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: August 9, 2011
    Assignee: General Electric Company
    Inventors: John Richard Nelson, Robert Scott Duthie, Sonali Jagdish Shah, Clifford Leslie Smith
  • METHODS AND KITS FOR REDUCING NON-SPECIFIC NUCLEIC ACID AMPLIFICATION
    Publication number: 20090130720
    Abstract: Methods and kits for efficient amplification of nucleic acids are provided. The methods comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having terminal mismatch primer-dimer structure. The methods also comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods enhance efficiency of nucleic acid amplification reaction by reducing non-specific amplification reactions.
    Type: Application
    Filed: December 18, 2008
    Publication date: May 21, 2009
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: John Richard Nelson, Robert Scott Duthie, Sonali Jagdish Shah, Clifford Leslie Smith