Patents by Inventor Clifton J. Blankley

Clifton J. Blankley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5620981
    Abstract: 6-Aryl pyrido[2,3-d]pyrimidine 7-imines, 7-ones, and 7-thiones are inhibitors of protein tyrosine kinases, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, Diane H. Boschelli, Annette M. Doherty, James M. Hamby, Sylvester Klutchko, Robert L. Panek
  • Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor antagonist properties
    Patent number: 5525614
    Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: June 11, 1996
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, John C. Hodges, Sylvester Klutchko
  • Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor antagonist properties
    Patent number: 5489686
    Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: February 6, 1996
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, John C. Hodges, Sylvester Klutchko
  • Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor antagonist properties
    Patent number: 5350757
    Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: September 27, 1994
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, John C. Hodges, Sylvester Klutchko
  • Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
    Patent number: 5246943
    Abstract: This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: September 21, 1993
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, John C. Hodges, Sylvester Klutchko
  • Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
    Patent number: 4503043
    Abstract: Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acid compounds and the pharmaceutically acceptable salts thereof are produced by acylating a suitably substituted octahydro-1H-isoindole with a suitably activated substituted carboxylic acid and when desired hydrolyzing the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as antihypertensive agents.
    Type: Grant
    Filed: June 14, 1982
    Date of Patent: March 5, 1985
    Assignee: Warner-Lambert Company
    Inventor: Clifton J. Blankley
  • 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
    Patent number: 4271164
    Abstract: 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives and their pharmaceutically acceptable acid addition salts are useful in the treatment of hypertension.
    Type: Grant
    Filed: March 11, 1980
    Date of Patent: June 2, 1981
    Assignee: Warner-Lambert Company
    Inventors: Clifton J. Blankley, Lawrence R. Bennett