Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.

Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.

Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.

Abstract: A Click Conversion Score (CCS) is a tool to provide a new “Ad-Exchange” for connecting Publishers and Advertisers in the Pay-per-Click advertising market. The CCS provides checks and balances into the Ad-Exchange by assessing the quality of traffic each Publisher provides Advertisers using an adaptive, multi-dimensional profiling system. This assessment is directly used in the charges billed the Advertisers. The score is adaptive, and highly dependent on the conversion feedback loop provided by Advertisers. A CCS system scores each Click and each resulting Conversion an Advertiser receives from the Ad-Exchange. In the preferred implementation, the score reflects a ratio of the measured conversion rate for a Publisher's traffic with the “expected” conversion rate based upon Advertisers histories.

Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.

Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.

Abstract: The present invention relates to Compound S of Formula (I).

Abstract: A compound of formula (I) wherein: R1 is an aryl group, unsubstituted or substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, aryl C1-C6 alkoxy, hydroxy, halo, CN, COR6, COOR6, NR6COR7, CONR8R9, SO2NR8R9, NR6SO2R7, NR8R9, halo C1-C4 alkyl, and halo C1-C4 alkoxy; W is CH and X is N, or W is N and X is CH, or W and X are CH; Y is C2-C4alkyl, R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, aryl C1-C6 alkoxy, hydroxy, halo, CN, COR6, carboxy, COOR6, NR6COR7, CONR8R9, SO2NR8R9, NR6SO2R7, NR8R9, mono to perfluoro-C1-C6 alkyl, or mono to perfluoro-C1-C6 alkoxy; n is 0-5; R3 is C1-C4 alkyl; R4 is C1-C4 alkyl; R5 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, halo C1-C4 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl C1-C4 alkyl, C5-C8cycloalkenyl, C5-C8cycloalkenyl C1-C4 alkyl, 3-8-membered heterocycloalkyl, 3-8-membered heterocycloalkyl C1-C4 alkyl, C6-C14 aryl, C6-C14 ar

Abstract: A compound of formula (I) wherein the various groups are defined herein, or a pharmaceutically acceptable salt thereof. These compounds are useful for treating atherosclerosis and other inflammatory diseases.

Abstract: A compound of formula (I) wherein the various groups are defined herein. or a pharmaceutically acceptable salt thereof. These compounds are useful for treating atherosclerosis and other inflammatory diseases.

Abstract: A content-provider entity provides content to media channels established in respect of a network communication session. The content-provider entity has a transport subsystem for establishing media channel connections to a session transport mechanism in accordance with channel type and connection details received by the entity. The content-provider entity also has a media subsystem providing a respective media handler of appropriate type for each media channel connection established by the transport subsystem. Each media handler is responsible for delivering media content of its associated type from a media source to the corresponding channel connection. A delivery controller of the media subsystem controls the selection and delivery of media content through the media handlers in dependence on context data supplied to the content-provider entity.

Abstract: The invention provides an enhanced video based surveillance system for use in the surveillance of a zone. The system firstly comprises the step of generating and storing an initial background image (14) of the zone wherein such image is composed of constant background features. Secondly the stored background image is used to partition incoming video images of the zone into segments visually representative of foreground features (16) and background features respectively. Finally foreground features are digitally enhanced (18) relative to the background features in the images, thereby to attract visual attention to such foreground features. The invention further extends to a video motion detection system incorporating the use of stereo calibrated digital cameras.

Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.

Abstract: This invention concerns a distributed stereo audio system (1). Distributed stereo audio systems are used to provide stereo sound to several rooms or areas from a single source of signal. The system includes two or more speakers (2, 3) for the broadcast of stereo audio signals; a source of stereo audio signals; a stereo amplifier (4) to amplify stereo audio signals and drive the speakers; and a mains operated electrical power supply (10) to provide power to the amplifier. The amplifier is located in the same room as the speakers, and remote from the signal source and power supply. The amplifier is connected to the signal source and power supply by means of a category 5 four pair twisted cable (11) which provides, in respective twisted pairs, right channel audio signals (12) from the signal source to the amplifier, left channel audio (13) from the signal source to the amplifier, DC power (14) from the power supply to the amplifier, and control signals (20) from the amplifier to the signal source.

Abstract: Compound of formula (I): are disclosed in which: R1 is an aryl group, optionally substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from C(1-6)alkyl, C(1-6)alkoxy, C(1-6)alkylthio, hydroxy, halogen, CN, and mono to perfluoro-C(1-4)alkyl; R2 is halogen, C(1-3)alkyl, C(1-3)alkoxy, hydroxyC(1-3)alkyl, C(1-3)alkylthio, C(1-3)alkylsulphinyl, aminoC(1-3)alkyl, mono- or di-C(1-3)alkylaminoC(1-3)alkyl, C(1-3)alkylcarbonylaminoC(1-3)alkyl, C(1-3)alkoxyC(1-3)alkylcarbonylaminoC(1-3)alkyl, C(1-3)alkylsulphonylaminoC(1-3)alkyl, C(1-3)alkylcarboxy, C(1-3)alkylcarboxyC(1-3)alkyl, and R3 is hydrogen, halogen, C(1-3)alkyl, or hydroxyC(1-3)alkcyl; or R2 and R3 together with the pyrimidone ring carbon atoms to which they are attached form a fused 5-or 6-membered carbocyclic ring; or R2 and R3 together with the pyrimidone ring carbon atoms to which they are attached form a fused benzo or heteroaryl ring ring optionally substituted by 1, 2, 3 or 4 substituents which may be the same or dif

Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use is treating atheroscelerosis.

Abstract: Pyrimidinone compounds of formula (10 are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.

Abstract: A storage device including a magnetic memory and a control circuit. The control circuit is configured to transfer selected data from the magnetic memory a selected number of times and to regulate the transfer of the selected data from the magnetic memory subsequent to transferring the selected data from the magnetic memory the selected number of times.

Abstract: This invention relates to a pumping system. The design of the system is such that bi-directional operation can be achieved using a significantly smaller and hence lighter unit than those currently available. It uses the direction of rotation of the drive shaft to control the opening and closure of the by-pass means for controllably returning the fluid to the first reservoir.

Abstract: A method is provided of establishing network communication later in time between a first endpoint entity accessing an information resource over a network and a second endpoint entity, such as a customer service representative system, associated with that resource. The method uses a service system that can set up a communication session and join endpoint systems to the session to enable them to communicate with each other the network. According to the method, upon the first endpoint entity indicating that it wishes to communicate with a second endpoint entity in the future, the service system generates and stores a session identifier for a communication session to be used in the future and passes a copy of the identifier over the network to the first endpoint entity.