Abstract: The present invention relates to a conditioning regimen for the transplant of a cell, tissue or organ, optionally hematopoietic stem / progenitor cells, to a subject. The invention also relates to methods for the induction of hematopoietic chimerism in a subject. The invention also relates to methods for the prevention or treatment of a disease or condition in a subject, in which hematopoietic chimerism is induced in order to improve the benefit to the subject of a subsequent therapy. The subsequent therapy may be a cell, tissue or organ transplant or may a gene therapy administered using genetically modified hematopoietic stem cells/progenitor cells.

Abstract: A process and apparatus for the treatment of hides and skins (3). The hide or skin is placed on a support (1, 2) and sealed to the support around the edges of the skin or hide. A treatment liquor is then supplied under pressure between the skin or hide and the support to distend and stretch the skin or hide to permit the more rapid penetration of the treatment liquor into the skin or hide.

Abstract: A process and apparatus for treating animal skins or hides (10) comprises stretching the hide to extend it and to open the structures and mounting the hide in a frame (15) by ties (12) extending between the hide edge attachments (11) and the frame. The hide (10) while in the frame. The hide (10) while in the frame passes through multiple process operations involving sequentially applying treatment fluids under pressure. A pressure differential maintained across the hide thickness enables the fluids to pass through the flesh surface (10a) and emerge from the grain surface (10b). The hide (10) can be supported on a porous backing membrane (45) during treatment. The treatment fluids are collected and processed for recycling, recovery of by-products and disposal.