Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Abstract: The present invention is directed to therapeutic compounds which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.

Abstract: Compounds of formula (I):or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of diabetes and obesity.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.

Abstract: The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula 1.

Abstract: There is provided a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition. The conjugate is attached to the polymer matrix through non-covalent interactions. There is also provided a drug delivery apparatus formed from the drug delivery composition.

Abstract: An apparatus (2) for the deployment of fascines comprises a fixed framework adapted to be mounted to the front region of a vehicle such as the glacis plate (3) of a tank (1). A leading portion of the framework extends forwardly of the vehicle and carries straps (18, 19) to support a bundle of inflatable fascine members (20). A winch (21) is mounted on the framework and can be used to raise the fascine members into the straps and subsequently to release the straps and allow the fascine members to drop into a ditch or other discontinuity and then inflate, to facilitate passage of the vehicle.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful for the treatment of diabetes and as peripheral regulators of satiety, e.g. for the treatment of obesity and metabolic syndrome.

Abstract: The present disclosure is directed towards a clamping assembly for compressing a plurality of optical plates of a high pressure cavitation system. The clamping assembly may include a mounting frame and a housing coupled to the mounting frame. The clamping assembly may further include a holder distal the housing, the holder having the plurality of optical plates disposed therein. The clamping assembly further including a controllable clamping mechanism operably coupled to a top of the housing, the controllable clamping mechanism applying an axial force to the plurality of optical plate.

Abstract: The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful for the treatment of diabetes and as peripheral regulators of satiety, e.g. for the treatment of obesity and metabolic syndrome.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.

Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-Oxide thereof, are useful in the treatment of cancer.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.

Abstract: The present disclosure provides an apparatus and method for removing particulates from a gas stream. The apparatus includes a ceramic filter, at least one electrode, and at least one conductor. The electrode is located at an end of the filter and produces an atmospheric glow discharge in order to oxidize carbon deposits trapped in the filter. The conductor extends at least partially into the filter and acts as a counter electrode. Through various arrangements of the electrodes and conductors, the present disclosure provides closer connection between the trapped carbon deposits and the electrodes. This improves the regeneration of the filter without increasing the size and/or weight of the apparatus.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts and esters thereof, are useful for the treatment of obesity, type II diabetes and the metabolic syndrome.

Abstract: Disclosed is a modular bridge, typically for temporary use to enable persons to pass between upper floors of adjacent buildings during fire fighting or disaster relief operations, which can be rapidly assembled and deployed within a confined space and entirely from the “home” side of the gap to be crossed. It comprises a plurality of man-portable box section bridge modules adapted to be connected together end to end and projected in cantilever fashion from one side of the gap to the other. The assembly of modules is supported in and guided through a launch frame, with modules being added to the rear of the assembly and pushed through the frame until the gap is spanned. Removable lever arms of the frame are used to counterbalance the weight of the projected bridge modules during the course of deployment.

Abstract: The provider network that interconnects user networks includes a plurality of edge routers. At least one of the plurality of edge routers includes an obtaining unit for obtaining information of a packet transferred by the edge router itself, a creating unit for creating a flow list in which flow information of packets transferred from the user network side to the provider network side is registered based on the packet information, a monitoring unit for monitoring a traffic state of a flow of each packet registered in the flow list based on information of packets transferred from the provider network to the user network, and a notifying unit for notifying the traffic state of the flow registered in the flow list to a maintenance engineer.

Abstract: The present disclosure is directed towards a clamping assembly for compressing a plurality of optical plates of a high pressure cavitation system. The clamping assembly may include a mounting frame and a housing coupled to the mounting frame. The clamping assembly may further include a holder distal the housing, the holder having the plurality of optical plates disposed therein. The clamping assembly further including a controllable clamping mechanism operably coupled to a top of the housing, the controllable clamping mechanism applying an axial force to the plurality of optical plate.