Abstract: There is a method for selective translation of a desired protein. The method has the steps of (a) providing a modified nucleic acid enzyme, including two half cores of a minimized 9DB1 deoxyribozyme split between nucleotides 35 and 39, wherein each half core includes a pendant assembly arm of a strand of nucleic acids extending therefrom and a separate, pendant binding arm extending therefrom of a strand of nucleic acids; (b) binding a nucleic acid ligand to each of the two assembly arms to form an intermediate; (c) binding the intermediate to (i) a first substrate of ribonucleic acid sequences capped at one end, (ii) a second substrate of a strand of ribonucleic acids having a 5? triphosphate region at one end and a region of polyadenylated nucleotides at the other end and wherein the second substrate codes for the desired protein, (iii) join the two half cores to form a core in order to form a ligated product; and (d) allowing the translation for the desired protein to proceed from the ligated product.

Abstract: A nanostructure is provided having a protein shell comprising one or more proteins, at least one nucleic acid scaffold with a plurality of nucleic acid recognition sequences configured to bind to a plurality of enzymes and a plurality of nucleic acid spacers between the plurality of nucleic acid recognition sequences, a linkage between the at least one nucleic acid scaffold and the protein shell, and the plurality of enzymes that are at least partially complementary to the at least one nucleic acid scaffold, each enzyme comprising a nucleic acid binding domain configured to bind the enzyme and the at least one nucleic acid scaffold with some degree of molecular complementarity.

Abstract: There is a method for selective translation of a desired protein. The method has the steps of (a) providing two half cores of a deoxyribozyme, wherein each half core includes a pendant assembly arm of a strand of nucleic acids extending therefrom and a separate, pendant binding arm extending therefrom of a strand of nucleic acids; (b) binding a nucleic acid ligand to each of the two assembly arms to form an intermediate; (c) binding the intermediate to (i) a first substrate of ribonucleic acid sequences capped at one end, (ii) a second substrate of a strand of ribonucleic acids having a 5? triphosphate region at one end and a region of polyadenylated nucleotides at the other end and wherein the second substrate codes for the desired protein, (iii) join the two half cores to form a core in order to form a ligated product; and (d) allowing the translation for the desired protein to proceed from the ligated product. There is another method for selective translation of a desired protein.