Abstract: A system and method for controlling navigation of a vehicle carrying hazardous materials includes a control module carried on-board the vehicle storing an information matrix containing hazardous material classifications associated with the identity and location of restricted sites. Each site and material pair has associated with it a control zone around it from which the hazardous material is restricted. The control module includes a positioning device that produces a signal indicating the vehicle's current position, which is compared to the coordinates for the control zones. If the vehicle crosses into a control zone, the system generates a warning to the operator. Further penetration causes the system to order a shutdown of the vehicle engine to prevent further movement.