Patents by Inventor Constantin Adrian Apetri

Constantin Adrian Apetri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Binding molecules that specifically bind to tau
    Patent number: 11274147
    Abstract: The invention relates to binding molecules and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using the binding molecules or antigen-binding fragments.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: March 15, 2022
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Constantin Adrian Apetri, Jaroslaw Juraszek, Roosmarijn Janson, Harmke Cornelia Verveen, Bunga Berdien Siregar
  • Methods for detection of Tau protein aggregation modulating compounds
    Patent number: 11249093
    Abstract: The present invention provides a method for the in vitro formation and/or detection of paired helical filaments (PHF) of Tau protein, comprising incubating a mixture comprising a Tau protein preparation and a polyanionic co-factor for a pre-determined period of time under conditions that promote the formation of PHFs.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: February 15, 2022
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Rosa Crespo Rodriguez, Constantin Adrian Apetri
  • Binding molecules that specifically bind to tau
    Patent number: 11028157
    Abstract: The invention relates to binding molecules and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using the binding molecules or antigen-binding fragments.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: June 8, 2021
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Jaroslaw Juraszek, Constantin Adrian Apetri
  • BINDING MOLECULES THAT SPECIFICALLY BIND TO TAU
    Publication number: 20210122810
    Abstract: The invention relates to binding molecules and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using the binding molecules or anti-gen-binding fragments.
    Type: Application
    Filed: March 27, 2018
    Publication date: April 29, 2021
    Inventors: Jaroslaw JURASZEK, Constantin Adrian APETRI
  • BINDING MOLECULES THAT SPECIFICALLY BIND TO TAU
    Publication number: 20210047393
    Abstract: The invention relates to binding molecules and antigen-binding fragments that specifically bind to microtubule-associated protein tau. The invention also relates to diagnostic, prophylactic and therapeutic methods using the binding molecules or antigen-binding fragments.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 18, 2021
    Inventors: Constantin Adrian APETRI, Jaroslaw JURASZEK, Roosmarijn JANSON, Harmke Cornelia VERVEEN, Bunga Berdien SIREGAR
  • METHODS FOR DETECTION OF TAU PROTEIN AGGREGATION MODULATING COMPOUNDS
    Publication number: 20200025777
    Abstract: The present invention provides a method for the in vitro formation and/or detection of paired helical filaments (PHF) of Tau protein, comprising incubating a mixture comprising a Tau protein preparation and a polyanionic co-factor for a pre-determined period of time under conditions that promote the formation of PHFs.
    Type: Application
    Filed: March 27, 2018
    Publication date: January 23, 2020
    Inventors: Rosa CRESPO RODRIGUEZ, Constantin Adrian APETRI
  • Human binding molecules capable of binding to and neutralizing hepatitis B viruses and uses thereof
    Patent number: 9512201
    Abstract: The disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to Hepatitis B viruses, and have a broad neutralizing activity against such Hepatitis B viruses. The disclosure further provides nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of Hepatitis B.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: December 6, 2016
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Ingrid van den Nieuwenhof, Marijn van der Neut Kolfschoten, Constantin Adrian Apetri, Robert H. E. Friesen
  • HUMAN BINDING MOLECULES CAPABLE OF BINDING TO AND NEUTRALIZING HEPATITIS B VIRUSES AND USES THEREOF
    Publication number: 20150232537
    Abstract: The disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to Hepatitis B viruses, and have a broad neutralizing activity against such Hepatitis B viruses. The disclosure further provides nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of Hepatitis B.
    Type: Application
    Filed: September 24, 2013
    Publication date: August 20, 2015
    Inventors: Ingrid van den Nieuwenhof, Marijn van der Neut Kolfschoten, Constantin Adrian Apetri, Robert H.E. Friesen