Patents by Inventor Constantin C. Coussios
Constantin C. Coussios has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11957124Abstract: A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.Type: GrantFiled: December 23, 2019Date of Patent: April 16, 2024Assignee: ORGANOX LIMITEDInventors: Stuart Brian William Kay, David George Robinson, Philip David Canner, Peter Alan Salkus, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Patent number: 11540508Abstract: An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (136, 137, 138), or a flow meter (125). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (113), and means (74) to measure the amount of fluid secreted by or leaked from the organ, may also be provided.Type: GrantFiled: November 8, 2016Date of Patent: January 3, 2023Assignee: Organox LimitedInventors: Stuart Brian William Kay, Sebastien Antoine Yves Cuvelier, Jonathan Richard Oakley, David George Robinson, Philip David Canner, Peter Alan Salkus, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Publication number: 20220249669Abstract: Described herein are processes and compositions for ultrasound-triggered liposome payload release, including a process for gelation and a process for enzyme catalysis.Type: ApplicationFiled: July 31, 2021Publication date: August 11, 2022Inventors: Valeria NELE, James P. ARMSTRONG, Molly M. STEVENS, Carolyn SCHUTT IBSEN, Michael D. GRAY, Constantin C. COUSSIOS
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Publication number: 20200128813Abstract: A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.Type: ApplicationFiled: December 23, 2019Publication date: April 30, 2020Inventors: Stuart Brian William Kay, David George Robinson, Philip David Canner, Peter Alan Salkus, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Patent number: 10362780Abstract: A perfusion system for the perfusion of an organ comprises a perfusion fluid circuit (16) for circulating perfusion fluid through the organ, oxygenation means (14) for adding oxygen into the perfusion fluid, and an oxygen supply arranged to supply oxygen to the oxygenation means. The oxygen supply comprises an oxygen concentrator.Type: GrantFiled: November 8, 2012Date of Patent: July 30, 2019Assignee: Organox LimitedInventors: Stuart Brian William Kay, Sebastien Antoine Yves Cuvelier, Jonathan Richard Oakley, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Patent number: 9662089Abstract: Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source.Type: GrantFiled: December 10, 2015Date of Patent: May 30, 2017Assignee: Oxford University Innovation LimitedInventors: Constantin C. Coussios, Miklos Gyongy, Manish Arora, Ronald Aurele Roy
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Publication number: 20170049096Abstract: An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (136, 137, 138), or a flow meter (125). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (113), and means (74) to measure the amount of fluid secreted by or leaked from the organ, may also be provided.Type: ApplicationFiled: November 8, 2016Publication date: February 23, 2017Inventors: Stuart Brian William Kay, Sebastien Antoine Yves Cuvelier, Jonathan Richard Oakley, David George Robinson, Philip David Canner, Peter Alan Salkus, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Publication number: 20170042141Abstract: A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.Type: ApplicationFiled: October 31, 2016Publication date: February 16, 2017Inventors: Stuart Brian William Kay, David George Robinson, Philip David Canner, Peter Alan Salkus, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Publication number: 20160089109Abstract: Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source.Type: ApplicationFiled: December 10, 2015Publication date: March 31, 2016Inventors: Constantin C. Coussios, Miklos Gyongy, Manish Arora, Ronald Aurele Roy
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Patent number: 9238152Abstract: Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source.Type: GrantFiled: November 4, 2009Date of Patent: January 19, 2016Assignee: Isis Innovation LimitedInventors: Constantin C. Coussios, Miklos Gyongy, Manish Arora, Ronald Aurele Roy
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Publication number: 20150004677Abstract: A perfusion system for the perfusion of an organ comprises a perfusion fluid circuit (16) for circulating perfusion fluid through the organ, oxygenation means (14) for adding oxygen into the perfusion fluid, and an oxygen supply arranged to supply oxygen to the oxygenation means. The oxygen supply comprises an oxygen concentrator.Type: ApplicationFiled: November 8, 2012Publication date: January 1, 2015Inventors: Stuart Brian William Kay, Sebastien Antoine Yves Cuvelier, Jonathan Richard Oakley, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Publication number: 20140377849Abstract: A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.Type: ApplicationFiled: November 8, 2012Publication date: December 25, 2014Inventors: Stuart Brian William Kay, David George Robinson, Philip David Canner, Peter Alan Salkus, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Publication number: 20140308654Abstract: An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (136, 137, 138), or a flow meter (125). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (113), and means (74) to measure the amount of fluid secreted by or leaked from the organ, may also be provided.Type: ApplicationFiled: November 8, 2012Publication date: October 16, 2014Applicant: Organox LimitedInventors: Stuart Brian William Kay, Sebastien Antoine Yves Cuvelier, Jonathan Richard Oakley, JR., David George Robinson, Philip David Canner, Peter Alan Salkus, Leslie James Russell, Peter John Friend, Constantin C. Coussios
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Publication number: 20120041309Abstract: Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source.Type: ApplicationFiled: November 4, 2009Publication date: February 16, 2012Applicant: ISIS INNOVATION LIMITEDInventors: Constantin C. Coussios, Miklos Gyongy, Manish Arora, Ronald Aurele Roy