Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A device includes an optic in an at least partially rigid scaffold. The scaffold is permeated, at least temporarily during a writing process, by writable media. The optic may be written into a writable volume in the scaffold defined by the writable media. The optic may be written by exposing the writable media to incident light to cause a material property change in the writable media within the writable volume.

Abstract: Oil-enhanced polymer modified asphalt adhesive compositions, membrane materials including the oil-enhanced polymer modified asphalt adhesive composition, and methods for making are provided. The oil-enhanced polymer modified asphalt adhesive compositions have improved elongation, recovery, heat resistance, and cold adhesion and may include a polymer modified asphalt and an oil or oil derivative additive. The polymer modified asphalt may include an elastomeric copolymer. The oil or oil derivative additive may include one or more of vegetable oils, nut oils, and seed oils. A membrane including the oil-enhance polymer modified asphalt is also provided. A multi-layered roofing membrane is also provided.

Abstract: Oil-enhanced polymer modified asphalt adhesive compositions, membrane materials including the oil-enhanced polymer modified asphalt adhesive composition, and methods for making are provided. The oil-enhanced polymer modified asphalt adhesive compositions have improved elongation, recovery, heat resistance, and cold adhesion and may include a polymer modified asphalt and an oil or oil derivative additive. The polymer modified asphalt may include an elastomeric copolymer. The oil or oil derivative additive may include one or more of vegetable oils, nut oils, and seed oils. A membrane including the oil-enhance polymer modified asphalt is also provided. A multi-layered roofing membrane is also provided.

Abstract: A device includes an optic in an at least partially rigid scaffold. The scaffold is permeated, at least temporarily during a writing process, by writable media. The optic may be written into a writable volume in the scaffold defined by the writable media. The optic may be written by exposing the writable media to incident light to cause a material property change in the writable media within the writable volume.

Abstract: Oil-enhanced polymer modified asphalt adhesive compositions, membrane materials including the oil-enhanced polymer modified asphalt adhesive composition, and methods for making are provided. The oil-enhanced polymer modified asphalt adhesive compositions have improved elongation, recovery, heat resistance, and cold adhesion and may include a polymer modified asphalt and an oil or oil derivative additive. The polymer modified asphalt may include an elastomeric copolymer. The oil or oil derivative additive may include one or more of vegetable oils, nut oils, and seed oils. A membrane including the oil-enhance polymer modified asphalt is also provided. A multi-layered roofing membrane is also provided.

Abstract: A method for making an orthopaedic implant, the method comprising: characterizing at least a portion of a bone corresponding to the bone to be replaced, said corresponding bone being on the contralateral side of the patient; providing a model of the orthopaedic implant based on a mirror image of the contralateral bone; and forming the orthopaedic implant based on the model.

Abstract: Oil-enhanced polymer modified asphalt adhesive compositions, membrane materials including the oil-enhanced polymer modified asphalt adhesive composition, and methods for making are provided. The oil-enhanced polymer modified asphalt adhesive compositions have improved elongation, recovery, heat resistance, and cold adhesion and may include a polymer modified asphalt and an oil or oil derivative additive. The polymer modified asphalt may include an elastomeric copolymer. The oil or oil derivative additive may include one or more of vegetable oils, nut oils, and seed oils. A membrane including the oil-enhance polymer modified asphalt is also provided. A multi-layered roofing membrane is also provided.

Abstract: A system and method of eye protection during a welding process comprising the steps of: fabricating a lens, where the lens includes a first degree of shading where the first degree of shading provides a first level of eye protection and a second degree of shading, where the second degree of shading provides a second level of protection, wherein the second level of eye protection shields a user's eye from welding flash rays; inserting photochromic sensing technology in the lens, where the photochromic sensing technology detects welding flash rays; and enabling the second degree of shading of the lens upon the detection of welding flash rays. Further, the second degree of shading continues while the lens is exposed to welding flash rays.

Abstract: A method for making an orthopaedic implant, the method comprising: characterizing at least a portion of a bone corresponding to the bone to be replaced, said corresponding bone being on the contralateral side of the patient; providing a model of the orthopaedic implant based on a mirror image of the contralateral bone; and forming the orthopaedic implant based on the model.

Abstract: A method for making an orthopaedic implant, the method comprising: characterizing at least a portion of a bone corresponding to the bone to be replaced, said corresponding bone being on the contralateral side of the patient; providing a model of the orthopaedic implant based on a mirror image of the contralateral bone; and forming the orthopaedic implant based on the model.