Abstract: In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).

Abstract: Systems and methods of controlling the performance of client nodes served by an electric power utility are provided. In one exemplary embodiment, a method performed by a first network node that is operable to control via a client node an electric motor configured to operate a pump jack comprises sending, to the client node, an indication to change an amount of electric power consumed by the motor to operate the pump jack based on at least one of a value of a first parameter associated with operation of the motor and a value of a second parameter associated with operation of the pump jack so as to reduce an average amount of electric power consumed during a certain time period by the motor in operating the pump jack.

Abstract: The present disclosure relates generally to the field of immunological-based assays and describes methods for measuring cell-mediated immuno responsiveness. More particularly, the present disclosure relates to methods, compositions, and kits for measuring cell-mediated immune response activity with enhanced sensitivity and improved storage stability.

Abstract: The present invention provides a device and methods of use related to the use of electrodes to continuously detect the presence and abundance of various biochemical compounds of interest with high spatial and temporal resolution, comprising the steps of inserting one or more electrodes in one or more locations selected from the group consisting of a tissue, an organ, a neural structure, a lymphatic vessel, a lymphatic node, an extravascular fluid compartment, and a peripheral blood vessel; applying a voltage scan to the electrode; an detecting a current indicative of the presence and abundance of the compound.

Abstract: Disclosed are T-cells that are positive for CD49f and which have an enhanced function compared to CD49f? cells. Methods of isolation of CD49f+ T-cells, as well as compositions and kits thereof are also disclosed. Additionally, enriched CD49f+T-cell populations have an increased proliferative potential, long-term survival and significantly improved efficacy in an adoptive therapeutic setting. The CD49f+ T-cells and CD49f+ T-cell enriched T-cell populations are useful in a range of applications, including for use in treating or inhibiting the development of diseases with immune dysfunction and methods of assessing risk of disease and potential responsiveness in immunotherapy. CD 19 CAR-T cells derived from CD49f+ T-cells and their use in a method of treatment of cancer is also disclosed.

Abstract: Provided herein are methods and compositions related to the selection T cells and/or subjects for adoptive immunotherapy based on the expression of one or more biomarkers.

Abstract: A sensor for the detection of an analyte in a fluid includes an electrode having a detection surface, a polydopamine layer adhered to the electrode detection surface; and optionally a receptor chemically functionalized to the polydopamine of the detection surface of the electrode. The receptor selectively binds to the analyte of interest and the analyte once bound is detectable by measuring the change of capacitance of the electrode.

Abstract: Provided herein are immunogenic polypeptides, compositions, and methods related to the development of CMV-specific prophylactic and/or therapeutic immunotherapy based on T cell epitopes (e.g., CMV epitopes) that are recognized by cytotoxic T cells (CTLs) and can be employed in the prevention and/or treatment of CMV infection, reactivation, and/or disease (e.g., CMV-associated end organ disease), especially in solid organ transplant recipients.

Abstract: Externally-damped electromechanical valve assemblies well-suited for deployment within high vibratory operating environments, such as those associated with work vehicle engines, are provided. In embodiments, the valve assembly includes a housing through which a flow passage extends, a valve element positioned in the flow passage, a valve actuator, and control electronics electrically coupled to the valve actuator. The valve assembly may also contain a constrained layer damper including a first mass element and a first viscoelastic layer. The first mass element is mounted in suspension to the housing exterior for movement relative thereto when the first mass element is excited by vibrations transmitted through the housing. Constrained between the first mass element and the housing exterior, the first viscoelastic layer deflects in shear as the first mass element moves relative to the housing to attenuate the vibrations transmitted through the housing by conversion of vibrational energy to heat.

Abstract: Provided herein are methods and compositions related to the selection T cells and/or subjects for adoptive immunotherapy based on the expression of one or more biomarkers.

Abstract: Described herein are systems, servers, devices, methods, and media for traffic management, including creating and launching traffic campaigns that target users with user selectable incentives for shifting transit behavior.

Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.

Abstract: Systems and methods of controlling the performance of client nodes served by an electric power utility are provided. In one exemplary embodiment, a method performed by a first network node that is operable to control via a client node an electric motor configured to operate a pump jack comprises sending, to the client node, an indication to change an amount of electric power consumed by the motor to operate the pump jack based on at least one of a value of a first parameter associated with operation of the motor and a value of a second parameter associated with operation of the pump jack so as to reduce an average amount of electric power consumed during a certain time period by the motor in operating the pump jack.

Abstract: Provided herein are compositions and methods related to the treatment of a CMV infection and/or cancer in a subject.

Abstract: Externally-damped electromechanical valve assemblies well-suited for deployment within high vibratory operating environments, such as those associated with work vehicle engines, are provided. In embodiments, the valve assembly includes a housing through which a flow passage extends, a valve element positioned in the flow passage, a valve actuator, and control electronics electrically coupled to the valve actuator. The valve assembly may also contain a constrained layer damper including a first mass element and a first viscoelastic layer. The first mass element is mounted in suspension to the housing exterior for movement relative thereto when the first mass element is excited by vibrations transmitted through the housing. Constrained between the first mass element and the housing exterior, the first viscoelastic layer deflects in shear as the first mass element moves relative to the housing to attenuate the vibrations transmitted through the housing by conversion of vibrational energy to heat.

Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.

Abstract: Provided herein are compositions and methods related to the treatment of multiple sclerosis in a subject.

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

Abstract: The present invention provides a device and methods of use related to the use of electrodes to detect the presence and abundance of various biochemical compounds of interest with high spatial and temporal resolution.