Patents by Inventor Cornelia J. Calhoun

Cornelia J. Calhoun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In situ hybridization method
    Patent number: 5719023
    Abstract: A method of identifying the presence of a known target sequence in nucleic acid contained in a fixed cellular or subcellular biological structure. By adding a stable, reporter-labeled RecA/single-stranded probe complex to the cellular or subcellular structure, the target sequence can be effectively labeled by in situ hybridization, allowing the target sequence to be visualized histologically and microscopically or detected by in situ cytometry or cell sorting flow techniques.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: February 17, 1998
    Assignee: Daikin Industries, Ltd.
    Inventors: David A. Zarling, Cornelia J. Calhoun, Elissa P. Sena
  • Diagnostic applications of double D-loop formation
    Patent number: 5670316
    Abstract: The present invention describes the formation of RecA protein catalyzed double-stranded probe:duplex linear target DNA complexes that are stable to deproteinization. The uses of this stable probe:target complex in diagnostic/DNA detection systems in in vitro and in situ DNA hybridization reactions is discussed. The probe:target complexes are also useful for diagnostic application in RecA protein facilitated DNA amplification reactions.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: September 23, 1997
    Assignee: Daikin Industries, Ltd.
    Inventors: Elissa P. Sena, Cornelia J. Calhoun, David A. Zarling
  • In situ hybridization method
    Patent number: 5506098
    Abstract: A method of identifying the presence of a known target sequence in double-stranded DNA contained in a fixed cellular or subcellular biological structure. By adding a stable, reporter-labeled RecA/single-stranded probe complex to the structure, the target sequence can be effectively labeled by in situ hybridization, allowing the target sequence to be visualized histologically and microscopically or detected by in situ cytometry or cell sorting flow techniques.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: April 9, 1996
    Assignee: Daikin Industries, Ltd.
    Inventors: David A. Zarling, Cornelia J. Calhoun, Elissa P. Sena
  • Diagnostic applications of double D-loop formation
    Patent number: 5273881
    Abstract: The present invention describes the formation of RecA protein catalyzed double-stranded probe:duplex linear target DNA complexes that are stable to deproteinization. The uses of this stable probe:target complex in diagnostic/DNA detection systems in in vitro and in situ DNA hybridization reactions is discussed. The probe:target complexes are also useful for diagnostic application in RecA protein facilitated DNA amplification reactions.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: December 28, 1993
    Assignee: Daikin Industries, Ltd.
    Inventors: Elissa P. Sena, Cornelia J. Calhoun, David A. Zarling