Abstract: A tool arrangement for forming a tunnel in a vertebra to perform nerve ablation includes a tamp having a distal end portion that includes a tip for creating the tunnel in the vertebra and a curvable portion to direct the tip along a curved path within the vertebra; a first cannula including a cannula body that is straight along an entire length of the cannula body and configured to receive the curvable portion of the tamp and straighten the curvable portion; and a tool hub including a stationary cannula attachment coupled to the first cannula and a movable head coupled to the tamp and configured to move toward or away from the stationary cannula attachment to extend or retract, respectively, the curvable portion of the tamp from or into, respectively, the first cannula.

Abstract: An RF ablation system can include a bipolar RF electrode that has two electrodes. Some bipolar RF electrodes can include a metal tube forming one of the electrodes. The metal tube can have cuts to facilitate bending of the metal tube. Some bipolar RF electrodes can include a multi-lumen tube for the conductors. Some multi-lumen tubes can be made of a relatively high durometer material to provide column strength to the bipolar RF electrodes. Some RF ablation systems can include an adapter for a RF generator to connect each electrode to a different channel. A variety of arrangement of the channels of the RF generator and the conductors of the bipolar RF electrode can be used to couple the electrodes and a temperature sensor to the RF generator.

Abstract: Disclosed herein are salt and solvate forms of. (1S,3?R,6?R,7?S,8?E,11?S,12?R)-6-chloro-7?-methoxy-11?,12?-dimethyl-3,4-dihydro-2H,15?H-spiro[naphthalene-1,22?-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]tetraen]-15?-one 13?,13?-dioxide (AMG 176): such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.

Abstract: A cellulosic structure including a cellulosic board substrate, a metal oxide layer positioned over the cellulosic board substrate, and a tie layer between the cellulosic board substrate and the metal oxide layer.